ANGEL1 — 98 ClinVar variants
All ClinVar germline ANGEL1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 96 flagged for review →
3 Likely benign · 95 Uncertain significance
Full ANGEL1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 96
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 74
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANGEL1 p.Ala162Gly Uncertain significance Single submitter
- ANGEL1 p.Ala186Glu Uncertain significance Single submitter
- ANGEL1 p.Ala333Gly Uncertain significance Single submitter
- ANGEL1 p.Ala3Thr Uncertain significance Single submitter
- ANGEL1 p.Ala412Val Uncertain significance Single submitter
- ANGEL1 p.Ala521Ser Uncertain significance Single submitter
- ANGEL1 p.Ala543Val Uncertain significance Single submitter
- ANGEL1 p.Ala546Thr Uncertain significance Single submitter
- ANGEL1 p.Ala76Pro Uncertain significance Single submitter
- ANGEL1 p.Arg15His Uncertain significance Single submitter
- ANGEL1 p.Arg18His Uncertain significance Single submitter
- ANGEL1 p.Arg278His Uncertain significance Single submitter
- ANGEL1 p.Arg323Lys Uncertain significance Single submitter
- ANGEL1 p.Arg399Gln Uncertain significance Single submitter
- ANGEL1 p.Arg509Gln Uncertain significance Single submitter
- ANGEL1 p.Arg50Trp Uncertain significance Single submitter
- ANGEL1 p.Arg563Gly Uncertain significance Single submitter
- ANGEL1 p.Arg587Cys Uncertain significance Single submitter
- ANGEL1 p.Arg620Lys Uncertain significance Single submitter
- ANGEL1 p.Arg65Gln Uncertain significance Single submitter
- ANGEL1 p.Asn274Ser Uncertain significance Single submitter
- ANGEL1 p.Asn645Ser Uncertain significance Single submitter
- ANGEL1 p.Asp116Gly Uncertain significance Single submitter
- ANGEL1 p.Asp330Asn Uncertain significance Single submitter
- ANGEL1 p.Asp401Ala Uncertain significance Single submitter
- ANGEL1 p.Asp401Asn Uncertain significance Single submitter
- ANGEL1 p.Asp439His Uncertain significance Single submitter
- ANGEL1 p.Asp83Asn Uncertain significance Single submitter
- ANGEL1 p.Asp96Gly Uncertain significance Single submitter
- ANGEL1 p.Cys332Ser Uncertain significance Single submitter
- ANGEL1 p.Cys5Tyr Uncertain significance Single submitter
- ANGEL1 p.Cys7Tyr Uncertain significance Single submitter
- ANGEL1 p.Gln153Pro Uncertain significance Single submitter
- ANGEL1 p.Gln173Lys Uncertain significance Single submitter
- ANGEL1 p.Gln584His Uncertain significance Single submitter
- ANGEL1 p.Gln88Arg Uncertain significance Single submitter
- ANGEL1 p.Glu176Gln Uncertain significance Single submitter
- ANGEL1 p.Glu217Asp Uncertain significance Single submitter
- ANGEL1 p.Glu42Gly Uncertain significance Single submitter
- ANGEL1 p.Glu42Lys Uncertain significance Single submitter
- ANGEL1 p.Glu556Val Uncertain significance Single submitter
- ANGEL1 p.Gly167Asp Uncertain significance Single submitter
- ANGEL1 p.Gly204Ala Uncertain significance Single submitter
- ANGEL1 p.Gly326Glu Uncertain significance Single submitter
- ANGEL1 p.Gly379Glu Uncertain significance Single submitter
- ANGEL1 p.Gly432Arg Uncertain significance Single submitter
- ANGEL1 p.His269Pro Uncertain significance Single submitter
- ANGEL1 p.His288Arg Uncertain significance Single submitter
- ANGEL1 p.His656Asn Uncertain significance Single submitter
- ANGEL1 p.Ile213Lys Uncertain significance Single submitter
- ANGEL1 p.Ile640Thr Uncertain significance Single submitter
- ANGEL1 p.Leu32Phe Uncertain significance Single submitter
- ANGEL1 p.Leu394Pro Uncertain significance Single submitter
- ANGEL1 p.Lys506Arg Uncertain significance Single submitter
- ANGEL1 p.Met314Leu Uncertain significance Single submitter
- ANGEL1 p.Met531Ile Uncertain significance Single submitter
- ANGEL1 p.Met593Val Uncertain significance Single submitter
- ANGEL1 p.Phe511Ile Uncertain significance Single submitter
- ANGEL1 p.Phe561Tyr Uncertain significance Single submitter
- ANGEL1 p.Phe606Leu Uncertain significance Single submitter
- ANGEL1 p.Pro135Leu Uncertain significance Single submitter
- ANGEL1 p.Pro156Leu Uncertain significance Single submitter
- ANGEL1 p.Pro178Ser Uncertain significance Single submitter
- ANGEL1 p.Pro189Ser Uncertain significance Single submitter
- ANGEL1 p.Pro199Leu Uncertain significance Single submitter
- ANGEL1 p.Pro208Ala Uncertain significance Single submitter
- ANGEL1 p.Pro650Arg Uncertain significance Single submitter
- ANGEL1 p.Ser154Leu Uncertain significance Single submitter
- ANGEL1 p.Ser555Leu Uncertain significance Single submitter
- ANGEL1 p.Thr14Lys Uncertain significance Single submitter
- ANGEL1 p.Thr537Ala Uncertain significance Single submitter
- ANGEL1 p.Tyr158Phe Uncertain significance Single submitter
- ANGEL1 p.Tyr265Cys Uncertain significance Single submitter
- ANGEL1 p.Tyr395His Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- ANGEL1 p.Arg342Cys Uncertain significance Single submitter
- ANGEL1 p.Arg398Cys Uncertain significance Single submitter
- ANGEL1 p.Arg514Cys Uncertain significance Single submitter
- ANGEL1 p.Arg632His Uncertain significance Single submitter
- ANGEL1 p.Asp160Asn Uncertain significance Single submitter
- ANGEL1 p.Cys658Gly Uncertain significance Single submitter
- ANGEL1 p.Glu301Lys Uncertain significance Single submitter
- ANGEL1 p.Gly664Arg Uncertain significance Single submitter
- ANGEL1 p.Gly68Trp Uncertain significance Single submitter
- ANGEL1 p.Leu344Val Uncertain significance Single submitter
- ANGEL1 p.Leu420Val Uncertain significance Single submitter
- ANGEL1 p.Pro128His Uncertain significance Single submitter
- ANGEL1 p.Pro372Ala Uncertain significance Single submitter
- ANGEL1 p.Pro385Gln Uncertain significance Single submitter
- ANGEL1 p.Pro385Leu Uncertain significance Single submitter
- ANGEL1 p.Ser38Phe Uncertain significance Single submitter
- ANGEL1 p.Ser496Phe Uncertain significance Single submitter
- ANGEL1 p.Ser519Gly Likely benign Single submitter
- ANGEL1 p.Thr535Ala Uncertain significance Single submitter
- ANGEL1 p.Val367Leu Uncertain significance Single submitter
- ANGEL1 p.Val374Ile Uncertain significance Single submitter
- ANGEL1 p.Val526Ile Uncertain significance Single submitter
All ANGEL1 variants
Likely benign 3
- p.Arg585His Single submitter
- p.Ile393Val Single submitter
- p.Ser519Gly Single submitter ⚠
Uncertain significance 95
- p.Ala162Gly Single submitter ⚠
- p.Ala186Glu Single submitter ⚠
- p.Ala333Gly Single submitter ⚠
- p.Ala3Thr Single submitter ⚠
- p.Ala412Val Single submitter ⚠
- p.Ala521Ser Single submitter ⚠
- p.Ala543Val Single submitter ⚠
- p.Ala546Thr Single submitter ⚠
- p.Ala76Pro Single submitter ⚠
- p.Arg15His Single submitter ⚠
- p.Arg18His Single submitter ⚠
- p.Arg278His Single submitter ⚠
- p.Arg323Lys Single submitter ⚠
- p.Arg342Cys Single submitter ⚠
- p.Arg398Cys Single submitter ⚠
- p.Arg399Gln Single submitter ⚠
- p.Arg509Gln Single submitter ⚠
- p.Arg50Trp Single submitter ⚠
- p.Arg514Cys Single submitter ⚠
- p.Arg563Gly Single submitter ⚠
- p.Arg587Cys Single submitter ⚠
- p.Arg620Lys Single submitter ⚠
- p.Arg632His Single submitter ⚠
- p.Arg65Gln Single submitter ⚠
- p.Asn274Ser Single submitter ⚠
- p.Asn645Ser Single submitter ⚠
- p.Asp116Gly Single submitter ⚠
- p.Asp160Asn Single submitter ⚠
- p.Asp330Asn Single submitter ⚠
- p.Asp401Ala Single submitter ⚠
- p.Asp401Asn Single submitter ⚠
- p.Asp439His Single submitter ⚠
- p.Asp83Asn Single submitter ⚠
- p.Asp96Gly Single submitter ⚠
- p.Cys332Ser Single submitter ⚠
- p.Cys5Tyr Single submitter ⚠
- p.Cys658Gly Single submitter ⚠
- p.Cys7Tyr Single submitter ⚠
- p.Gln153Pro Single submitter ⚠
- p.Gln173Lys Single submitter ⚠
- p.Gln584His Single submitter ⚠
- p.Gln88Arg Single submitter ⚠
- p.Glu176Gln Single submitter ⚠
- p.Glu217Asp Single submitter ⚠
- p.Glu301Lys Single submitter ⚠
- p.Glu42Gly Single submitter ⚠
- p.Glu42Lys Single submitter ⚠
- p.Glu556Val Single submitter ⚠
- p.Gly167Asp Single submitter ⚠
- p.Gly204Ala Single submitter ⚠
- p.Gly326Glu Single submitter ⚠
- p.Gly379Glu Single submitter ⚠
- p.Gly432Arg Single submitter ⚠
- p.Gly664Arg Single submitter ⚠
- p.Gly68Trp Single submitter ⚠
- p.His269Pro Single submitter ⚠
- p.His288Arg Single submitter ⚠
- p.His656Asn Single submitter ⚠
- p.Ile213Lys Single submitter ⚠
- p.Ile640Thr Single submitter ⚠
- p.Leu32Phe Single submitter ⚠
- p.Leu344Val Single submitter ⚠
- p.Leu394Pro Single submitter ⚠
- p.Leu420Val Single submitter ⚠
- p.Lys506Arg Single submitter ⚠
- p.Met314Leu Single submitter ⚠
- p.Met531Ile Single submitter ⚠
- p.Met593Val Single submitter ⚠
- p.Phe511Ile Single submitter ⚠
- p.Phe561Tyr Single submitter ⚠
- p.Phe606Leu Single submitter ⚠
- p.Pro128His Single submitter ⚠
- p.Pro135Leu Single submitter ⚠
- p.Pro156Leu Single submitter ⚠
- p.Pro178Ser Single submitter ⚠
- p.Pro189Ser Single submitter ⚠
- p.Pro199Leu Single submitter ⚠
- p.Pro208Ala Single submitter ⚠
- p.Pro372Ala Single submitter ⚠
- p.Pro385Gln Single submitter ⚠
- p.Pro385Leu Single submitter ⚠
- p.Pro650Arg Single submitter ⚠
- p.Ser154Leu Single submitter ⚠
- p.Ser38Phe Single submitter ⚠
- p.Ser496Phe Single submitter ⚠
- p.Ser555Leu Single submitter ⚠
- p.Thr14Lys Single submitter ⚠
- p.Thr535Ala Single submitter ⚠
- p.Thr537Ala Single submitter ⚠
- p.Tyr158Phe Single submitter ⚠
- p.Tyr265Cys Single submitter ⚠
- p.Tyr395His Single submitter ⚠
- p.Val367Leu Single submitter ⚠
- p.Val374Ile Single submitter ⚠
- p.Val526Ile Single submitter ⚠