ANGPT4 — 79 ClinVar variants
All ClinVar germline ANGPT4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 69 flagged for review →
3 Benign · 8 Likely benign · 68 Uncertain significance
Full ANGPT4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 69
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANGPT4 p.Ala233Ser Uncertain significance Single submitter
- ANGPT4 p.Ala275Thr Uncertain significance Single submitter
- ANGPT4 p.Ala277Val Uncertain significance Single submitter
- ANGPT4 p.Ala279Asp Uncertain significance Single submitter
- ANGPT4 p.Arg242His Uncertain significance Single submitter
- ANGPT4 p.Arg334Ser Uncertain significance Single submitter
- ANGPT4 p.Arg480Cys Uncertain significance Single submitter
- ANGPT4 p.Asn175Asp Uncertain significance Single submitter
- ANGPT4 p.Asn175Lys Uncertain significance Single submitter
- ANGPT4 p.Asn175Ser Uncertain significance Single submitter
- ANGPT4 p.Asn463Lys Uncertain significance Single submitter
- ANGPT4 p.Asp438Asn Uncertain significance Single submitter
- ANGPT4 p.Cys457Tyr Uncertain significance Single submitter
- ANGPT4 p.Gln125Arg Uncertain significance Single submitter
- ANGPT4 p.Gln209Leu Uncertain significance Single submitter
- ANGPT4 p.Gln92Glu Uncertain significance Single submitter
- ANGPT4 p.Glu117Gly Uncertain significance Single submitter
- ANGPT4 p.Glu238Gln Uncertain significance Single submitter
- ANGPT4 p.Glu271Gln Uncertain significance Single submitter
- ANGPT4 p.Glu271Lys Uncertain significance Single submitter
- ANGPT4 p.Glu34Lys Uncertain significance Single submitter
- ANGPT4 p.Glu359Lys Uncertain significance Single submitter
- ANGPT4 p.Glu395Asp Uncertain significance Single submitter
- ANGPT4 p.Gly352Arg Uncertain significance Single submitter
- ANGPT4 p.Gly354Arg Uncertain significance Single submitter
- ANGPT4 p.His396Arg Uncertain significance Single submitter
- ANGPT4 p.His439Arg Uncertain significance Single submitter
- ANGPT4 p.Ile216Met Uncertain significance Single submitter
- ANGPT4 p.Leu261Val Uncertain significance Single submitter
- ANGPT4 p.Leu36Val Uncertain significance Single submitter
- ANGPT4 p.Leu370His Uncertain significance Single submitter
- ANGPT4 p.Leu77Arg Uncertain significance Single submitter
- ANGPT4 p.Lys148Arg Uncertain significance Single submitter
- ANGPT4 p.Met19Thr Uncertain significance Single submitter
- ANGPT4 p.Phe171Cys Uncertain significance Single submitter
- ANGPT4 p.Pro168Ser Uncertain significance Single submitter
- ANGPT4 p.Ser421Asn Uncertain significance Single submitter
- ANGPT4 p.Thr226Arg Uncertain significance Single submitter
- ANGPT4 p.Trp100Gly Uncertain significance Single submitter
- ANGPT4 p.Trp329Arg Uncertain significance Single submitter
- ANGPT4 p.Val244Ile Uncertain significance Single submitter
- ANGPT4 p.Val37Leu Uncertain significance Single submitter
- ANGPT4 p.Val61Gly Uncertain significance Single submitter
Predictors split 26
The independent predictors disagree with each other — read with care.
- ANGPT4 p.Ala445Thr Uncertain significance Single submitter
- ANGPT4 p.Arg334Cys Uncertain significance Single submitter
- ANGPT4 p.Arg379Cys Uncertain significance Single submitter
- ANGPT4 p.Arg499Trp Uncertain significance Single submitter
- ANGPT4 p.Asn140Ser Uncertain significance Single submitter
- ANGPT4 p.Asn179Tyr Uncertain significance Single submitter
- ANGPT4 p.Asn247Asp Uncertain significance Single submitter
- ANGPT4 p.Gln141Lys Uncertain significance Single submitter
- ANGPT4 p.Gly415Ser Uncertain significance Single submitter
- ANGPT4 p.Gly41Asp Uncertain significance Single submitter
- ANGPT4 p.Gly41Ser Uncertain significance Single submitter
- ANGPT4 p.His78Tyr Uncertain significance Single submitter
- ANGPT4 p.Leu13Phe Uncertain significance Single submitter
- ANGPT4 p.Leu264Phe Uncertain significance Single submitter
- ANGPT4 p.Pro315Leu Uncertain significance Single submitter
- ANGPT4 p.Pro315Ser Uncertain significance Single submitter
- ANGPT4 p.Ser377Cys Uncertain significance Single submitter
- ANGPT4 p.Thr110Met Likely benign Single submitter
- ANGPT4 p.Thr306Ile Uncertain significance Single submitter
- ANGPT4 p.Thr313Met Uncertain significance Single submitter
- ANGPT4 p.Thr330Ser Uncertain significance Single submitter
- ANGPT4 p.Thr371Ala Uncertain significance Single submitter
- ANGPT4 p.Thr98Met Uncertain significance Single submitter
- ANGPT4 p.Val309Met Uncertain significance Single submitter
- ANGPT4 p.Val340Met Uncertain significance Single submitter
- ANGPT4 p.Val87Ala Uncertain significance Single submitter
All ANGPT4 variants
Benign 3
- p.Glu117= Multiple submitters
- p.Ser435= Multiple submitters
- p.Leu172Arg Single submitter
Likely benign 8
- p.Ala221Glu Single submitter
- p.Arg259Ser Single submitter
- p.Asp471Asn Single submitter
- p.Leu264Val Single submitter
- p.Thr110Met Single submitter ⚠
- p.Thr128= Single submitter
- p.Thr84Ala Single submitter
- p.Val465Ile Single submitter
Uncertain significance 68
- p.Ala233Ser Single submitter ⚠
- p.Ala275Thr Single submitter ⚠
- p.Ala277Val Single submitter ⚠
- p.Ala279Asp Single submitter ⚠
- p.Ala445Thr Single submitter ⚠
- p.Arg242His Single submitter ⚠
- p.Arg334Cys Single submitter ⚠
- p.Arg334Ser Single submitter ⚠
- p.Arg379Cys Single submitter ⚠
- p.Arg480Cys Single submitter ⚠
- p.Arg499Trp Single submitter ⚠
- p.Asn140Ser Single submitter ⚠
- p.Asn175Asp Single submitter ⚠
- p.Asn175Lys Single submitter ⚠
- p.Asn175Ser Single submitter ⚠
- p.Asn179Tyr Single submitter ⚠
- p.Asn247Asp Single submitter ⚠
- p.Asn463Lys Single submitter ⚠
- p.Asp438Asn Single submitter ⚠
- p.Cys457Tyr Single submitter ⚠
- p.Gln125Arg Single submitter ⚠
- p.Gln141Lys Single submitter ⚠
- p.Gln209Leu Single submitter ⚠
- p.Gln92Glu Single submitter ⚠
- p.Glu117Gly Single submitter ⚠
- p.Glu238Gln Single submitter ⚠
- p.Glu271Gln Single submitter ⚠
- p.Glu271Lys Single submitter ⚠
- p.Glu34Lys Single submitter ⚠
- p.Glu359Lys Single submitter ⚠
- p.Glu395Asp Single submitter ⚠
- p.Gly352Arg Single submitter ⚠
- p.Gly354Arg Single submitter ⚠
- p.Gly415Ser Single submitter ⚠
- p.Gly41Asp Single submitter ⚠
- p.Gly41Ser Single submitter ⚠
- p.His396Arg Single submitter ⚠
- p.His439Arg Single submitter ⚠
- p.His78Tyr Single submitter ⚠
- p.Ile216Met Single submitter ⚠
- p.Leu13Phe Single submitter ⚠
- p.Leu261Val Single submitter ⚠
- p.Leu264Phe Single submitter ⚠
- p.Leu36Val Single submitter ⚠
- p.Leu370His Single submitter ⚠
- p.Leu77Arg Single submitter ⚠
- p.Lys148Arg Single submitter ⚠
- p.Met19Thr Single submitter ⚠
- p.Phe171Cys Single submitter ⚠
- p.Pro168Ser Single submitter ⚠
- p.Pro315Leu Single submitter ⚠
- p.Pro315Ser Single submitter ⚠
- p.Ser377Cys Single submitter ⚠
- p.Ser421Asn Single submitter ⚠
- p.Thr226Arg Single submitter ⚠
- p.Thr306Ile Single submitter ⚠
- p.Thr313Met Single submitter ⚠
- p.Thr330Ser Single submitter ⚠
- p.Thr371Ala Single submitter ⚠
- p.Thr98Met Single submitter ⚠
- p.Trp100Gly Single submitter ⚠
- p.Trp329Arg Single submitter ⚠
- p.Val244Ile Single submitter ⚠
- p.Val309Met Single submitter ⚠
- p.Val340Met Single submitter ⚠
- p.Val37Leu Single submitter ⚠
- p.Val61Gly Single submitter ⚠
- p.Val87Ala Single submitter ⚠