ANKRD24 — 232 ClinVar variants

All ClinVar germline ANKRD24 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 215 flagged for review →

1 Likely pathogenic · 14 Likely benign · 217 Uncertain significance

Full ANKRD24 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 215

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 176

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 176

Predictors split 39

The independent predictors disagree with each other — read with care.

All ANKRD24 variants

Likely pathogenic 1

p.Thr645fs Single submitter Genetic hearing loss

Likely benign 14

p.Ala156Val Single submitter
p.Ala182Thr Single submitter
p.Ala714= Single submitter
p.Asn1067Ser Single submitter
p.Asn557= Single submitter
p.Glu580Ala Single submitter ⚠
p.Glu615Ala Single submitter
p.Gly656Arg Single submitter
p.Leu174Pro Single submitter ⚠
p.Leu422Phe Single submitter
p.Met316Val Single submitter
p.Ser1107= Single submitter
p.Thr582Met Single submitter
p.Thr700Met Single submitter

Uncertain significance 217

p.Val1108Met Multiple submitters ⚠
p.Ala1015Thr Single submitter ⚠
p.Ala1034Thr Single submitter ⚠
p.Ala1040Asp Single submitter ⚠
p.Ala1040Val Single submitter ⚠
p.Ala1047Thr Single submitter ⚠
p.Ala1077Val Single submitter ⚠
p.Ala1102Val Single submitter ⚠
p.Ala111Val Single submitter ⚠
p.Ala182Ser Single submitter ⚠
p.Ala205Thr Single submitter
p.Ala257Val Single submitter ⚠
p.Ala269Val Single submitter ⚠
p.Ala301Val Single submitter ⚠
p.Ala307Val Single submitter ⚠
p.Ala442Thr Single submitter ⚠
p.Ala504Thr Single submitter ⚠
p.Ala551Pro Single submitter ⚠
p.Ala574Ser Single submitter ⚠
p.Ala591Asp Single submitter ⚠
p.Ala616Gly Single submitter ⚠
p.Ala647Thr Single submitter ⚠
p.Ala650Thr Single submitter ⚠
p.Ala744Gly Single submitter ⚠
p.Ala745Val Single submitter ⚠
p.Ala757Thr Single submitter ⚠
p.Ala810Val Single submitter ⚠
p.Ala834Thr Single submitter ⚠
p.Ala837Thr Single submitter ⚠
p.Ala85Ser Single submitter ⚠
p.Ala85Thr Single submitter ⚠
p.Ala860Val Single submitter ⚠
p.Ala905Val Single submitter ⚠
p.Ala926Val Single submitter ⚠
p.Ala94Val Single submitter ⚠
p.Ala997Ser Single submitter ⚠
p.Arg1004His Single submitter ⚠
p.Arg1013Pro Single submitter ⚠
p.Arg1028Gln Single submitter ⚠
p.Arg1038Cys Single submitter ⚠
p.Arg1038Leu Single submitter ⚠
p.Arg1088Cys Single submitter ⚠
p.Arg1103Ser Single submitter ⚠
p.Arg1130Trp Single submitter ⚠
p.Arg1140Ser Single submitter ⚠
p.Arg1146Cys Single submitter ⚠
p.Arg1146His Single submitter ⚠
p.Arg179Gln Single submitter ⚠
p.Arg179Leu Single submitter ⚠
p.Arg179Pro Single submitter ⚠
p.Arg179Trp Single submitter ⚠
p.Arg272Cys Single submitter ⚠
p.Arg272His Single submitter ⚠
p.Arg305Gln Single submitter ⚠
p.Arg320Gly Single submitter ⚠
p.Arg335Cys Single submitter ⚠
p.Arg335His Single submitter ⚠
p.Arg349Trp Single submitter ⚠
p.Arg365Gly Single submitter ⚠
p.Arg386Gln Single submitter ⚠
p.Arg386Trp Single submitter ⚠
p.Arg394Trp Single submitter ⚠
p.Arg402Gln Single submitter ⚠
p.Arg40Cys Single submitter ⚠
p.Arg40His Single submitter ⚠
p.Arg431Gly Single submitter ⚠
p.Arg500His Single submitter ⚠
p.Arg70Leu Single submitter ⚠
p.Arg730His Single submitter ⚠
p.Arg737Trp Single submitter ⚠
p.Arg739Trp Single submitter ⚠
p.Arg765Pro Single submitter ⚠
p.Arg822Gln Single submitter ⚠
p.Arg822Gly Single submitter ⚠
p.Arg822Pro Single submitter ⚠
p.Arg830Trp Single submitter ⚠
p.Arg843Trp Single submitter ⚠
p.Arg848Gln Single submitter ⚠
p.Arg878Trp Single submitter ⚠
p.Arg884Gly Single submitter ⚠
p.Arg896Trp Single submitter ⚠
p.Arg903Trp Single submitter ⚠
p.Arg920Cys Single submitter ⚠
p.Arg930Trp Single submitter ⚠
p.Arg932Gln Single submitter ⚠
p.Arg990Leu Single submitter ⚠
p.Asn1067Thr Single submitter ⚠
p.Asn617Asp Single submitter ⚠
p.Asp211Asn Single submitter
p.Asp283Tyr Single submitter ⚠
p.Asp421Asn Single submitter ⚠
p.Asp497Asn Single submitter ⚠
p.Asp802Glu Single submitter ⚠
p.Asp816Glu Single submitter ⚠
p.Cys892Tyr Single submitter ⚠
p.Gln1026His Single submitter ⚠
p.Gln1095Arg Single submitter ⚠
p.Gln1097Glu Single submitter ⚠
p.Gln190Leu Single submitter ⚠
p.Gln213Arg Single submitter ⚠
p.Gln290Arg Single submitter ⚠
p.Glu1005Asp Single submitter ⚠
p.Glu1017Lys Single submitter ⚠
p.Glu1024Gln Single submitter ⚠
p.Glu1083Lys Single submitter ⚠
p.Glu286Lys Single submitter ⚠
p.Glu324Lys Single submitter ⚠
p.Glu356Gln Single submitter ⚠
p.Glu415Lys Single submitter ⚠
p.Glu457Ala Single submitter ⚠
p.Glu482Asp Single submitter ⚠
p.Glu495Lys Single submitter ⚠
p.Glu50Lys Single submitter ⚠
p.Glu517Asp Single submitter ⚠
p.Glu522Gln Single submitter ⚠
p.Glu528Lys Single submitter ⚠
p.Glu530Ala Single submitter ⚠
p.Glu605Gly Single submitter ⚠
p.Glu608Asp Single submitter ⚠
p.Glu613Gln Single submitter ⚠
p.Glu613Lys Single submitter ⚠
p.Glu651Lys Single submitter ⚠
p.Glu673Gln Single submitter ⚠
p.Glu733Gln Single submitter ⚠
p.Glu772Lys Single submitter ⚠
p.Glu81Lys Single submitter ⚠
p.Glu828Ala Single submitter ⚠
p.Glu845Lys Single submitter ⚠
p.Glu873Asp Single submitter ⚠
p.Glu901Lys Single submitter ⚠
p.Glu925Ala Single submitter ⚠
p.Glu928Gly Single submitter ⚠
p.Glu998Asp Single submitter ⚠
p.Gly148Arg Single submitter ⚠
p.Gly342Asp Single submitter ⚠
p.Gly533Arg Single submitter ⚠
p.Gly548Val Single submitter ⚠
p.Gly603Arg Single submitter ⚠
p.Gly634Val Single submitter ⚠
p.Gly656Glu Single submitter ⚠
p.Gly681Arg Single submitter ⚠
p.Gly681Glu Single submitter ⚠
p.Gly779Val Single submitter ⚠
p.Gly831Arg Single submitter ⚠
p.His252Arg Single submitter ⚠
p.Ile186Ser Single submitter ⚠
p.Ile262Val Single submitter ⚠
p.Ile31Thr Single submitter ⚠
p.Leu1027Ile Single submitter ⚠
p.Leu1087Phe Single submitter ⚠
p.Leu196Gln Single submitter ⚠
p.Leu218Met Single submitter
p.Leu261Phe Single submitter ⚠
p.Leu263Val Single submitter ⚠
p.Leu398Pro Single submitter ⚠
p.Leu844Val Single submitter ⚠
p.Leu981Met Single submitter ⚠
p.Leu981Val Single submitter ⚠
p.Lys132Asn Single submitter ⚠
p.Lys260Thr Single submitter ⚠
p.Lys347Glu Single submitter ⚠
p.Lys555Glu Single submitter ⚠
p.Lys595Arg Single submitter ⚠
p.Lys720Glu Single submitter ⚠
p.Lys994Thr Single submitter ⚠
p.Met191Val Single submitter ⚠
p.Met459Ile Single submitter ⚠
p.Met475Ile Single submitter ⚠
p.Met577Arg Single submitter ⚠
p.Met577Lys Single submitter ⚠
p.Met638Ile Single submitter ⚠
p.Met638Lys Single submitter ⚠
p.Phe86Leu Single submitter ⚠
p.Pro275Gln Single submitter ⚠
p.Pro302Thr Single submitter ⚠
p.Pro317Leu Single submitter ⚠
p.Pro32Leu Single submitter ⚠
p.Pro34Leu Single submitter ⚠
p.Pro34Ser Single submitter ⚠
p.Pro355Leu Single submitter ⚠
p.Pro423Leu Single submitter ⚠
p.Pro435Leu Single submitter ⚠
p.Pro702Leu Single submitter ⚠
p.Ser1011Asn Single submitter ⚠
p.Ser1011Thr Single submitter ⚠
p.Ser1107Ile Single submitter ⚠
p.Ser22Phe Single submitter ⚠
p.Ser277Arg Single submitter ⚠
p.Ser436Leu Single submitter ⚠
p.Ser529Thr Single submitter ⚠
p.Ser677Pro Single submitter ⚠
p.Ser688Thr Single submitter ⚠
p.Ser965Trp Single submitter ⚠
p.Ser96Gly Single submitter ⚠
p.Ser996Arg Single submitter ⚠
p.Thr183Ile Single submitter ⚠
p.Thr280Ile Single submitter ⚠
p.Thr576Ile Single submitter ⚠
p.Thr587Met Single submitter ⚠
p.Thr630Lys Single submitter ⚠
p.Thr633Met Single submitter ⚠
p.Thr667Ile Single submitter ⚠
p.Thr859Met Single submitter ⚠
p.Thr863Met Single submitter ⚠
p.Thr869Met Single submitter ⚠
p.Thr995Ile Single submitter ⚠
p.Tyr116Cys Single submitter ⚠
p.Tyr253Cys Single submitter ⚠
p.Tyr489Cys Single submitter
p.Val140Met Single submitter ⚠
p.Val143Ile Single submitter ⚠
p.Val701Ile Single submitter ⚠
p.Val723Gly Single submitter ⚠
p.Val723Ile Single submitter ⚠
p.Val74Ala Single submitter ⚠
p.Val940Ala Single submitter ⚠
p.Val941Gly Single submitter ⚠