ANO9 — 148 ClinVar variants
All ClinVar germline ANO9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 126 flagged for review →
1 Benign · 15 Likely benign · 132 Uncertain significance
Full ANO9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 126
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 110
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANO9 p.Ala101Val Uncertain significance Single submitter
- ANO9 p.Ala104Thr Uncertain significance Single submitter
- ANO9 p.Ala108Thr Uncertain significance Single submitter
- ANO9 p.Ala221Ser Uncertain significance Single submitter
- ANO9 p.Ala275Pro Uncertain significance Single submitter
- ANO9 p.Ala30Ser Uncertain significance Single submitter
- ANO9 p.Ala30Thr Uncertain significance Single submitter
- ANO9 p.Ala360Val Uncertain significance Single submitter
- ANO9 p.Ala467Thr Uncertain significance Single submitter
- ANO9 p.Ala609Val Uncertain significance Single submitter
- ANO9 p.Ala759Val Uncertain significance Single submitter
- ANO9 p.Ala767Thr Uncertain significance Single submitter
- ANO9 p.Arg121Gln Uncertain significance Single submitter
- ANO9 p.Arg159Cys Uncertain significance Single submitter
- ANO9 p.Arg172Trp Uncertain significance Single submitter
- ANO9 p.Arg244His Uncertain significance Single submitter
- ANO9 p.Arg248Gln Uncertain significance Single submitter
- ANO9 p.Arg291Cys Uncertain significance Single submitter
- ANO9 p.Arg291His Uncertain significance Single submitter
- ANO9 p.Arg321Gln Uncertain significance Single submitter
- ANO9 p.Arg321Leu Uncertain significance Single submitter
- ANO9 p.Arg355His Uncertain significance Single submitter
- ANO9 p.Arg423His Uncertain significance Single submitter
- ANO9 p.Arg42Cys Uncertain significance Single submitter
- ANO9 p.Arg455His Uncertain significance Single submitter
- ANO9 p.Arg524Trp Uncertain significance Single submitter
- ANO9 p.Arg684Cys Uncertain significance Single submitter
- ANO9 p.Arg702Leu Uncertain significance Single submitter
- ANO9 p.Arg742Thr Uncertain significance Single submitter
- ANO9 p.Arg744His Uncertain significance Single submitter
- ANO9 p.Arg744Ser Uncertain significance Single submitter
- ANO9 p.Arg762Trp Uncertain significance Single submitter
- ANO9 p.Arg81Cys Uncertain significance Single submitter
- ANO9 p.Arg8Trp Uncertain significance Single submitter
- ANO9 p.Asp233Asn Uncertain significance Single submitter
- ANO9 p.Asp233Gly Uncertain significance Single submitter
- ANO9 p.Asp539Asn Uncertain significance Single submitter
- ANO9 p.Asp83Asn Uncertain significance Single submitter
- ANO9 p.Cys315Tyr Uncertain significance Single submitter
- ANO9 p.Cys491Phe Uncertain significance Single submitter
- ANO9 p.Gln223His Uncertain significance Single submitter
- ANO9 p.Gln54Arg Uncertain significance Single submitter
- ANO9 p.Glu139Lys Uncertain significance Single submitter
- ANO9 p.Glu14Asp Uncertain significance Single submitter
- ANO9 p.Glu14Gln Uncertain significance Single submitter
- ANO9 p.Glu27Lys Uncertain significance Single submitter
- ANO9 p.Glu29Lys Uncertain significance Single submitter
- ANO9 p.Glu303Asp Uncertain significance Single submitter
- ANO9 p.Glu519Lys Uncertain significance Single submitter
- ANO9 p.Glu540Lys Uncertain significance Single submitter
- ANO9 p.Glu58Gln Uncertain significance Single submitter
- ANO9 p.Glu737Lys Uncertain significance Single submitter
- ANO9 p.Glu96Asp Uncertain significance Single submitter
- ANO9 p.Glu98Lys Uncertain significance Single submitter
- ANO9 p.Gly145Arg Uncertain significance Single submitter
- ANO9 p.Gly208Val Uncertain significance Single submitter
- ANO9 p.Gly215Arg Uncertain significance Single submitter
- ANO9 p.Gly240Arg Uncertain significance Single submitter
- ANO9 p.Gly346Ser Uncertain significance Single submitter
- ANO9 p.Gly451Arg Uncertain significance Single submitter
- ANO9 p.Gly451Trp Uncertain significance Single submitter
- ANO9 p.Gly649Val Uncertain significance Single submitter
- ANO9 p.Gly756Glu Uncertain significance Single submitter
- ANO9 p.His325Tyr Uncertain significance Single submitter
- ANO9 p.His659Gln Uncertain significance Single submitter
- ANO9 p.His749Arg Uncertain significance Single submitter
- ANO9 p.Ile624Thr Uncertain significance Single submitter
- ANO9 p.Leu239Val Uncertain significance Single submitter
- ANO9 p.Leu261Ile Uncertain significance Single submitter
- ANO9 p.Leu560Pro Uncertain significance Single submitter
- ANO9 p.Leu560Val Uncertain significance Single submitter
- ANO9 p.Leu587Val Uncertain significance Single submitter
- ANO9 p.Leu608Arg Uncertain significance Single submitter
- ANO9 p.Leu608Val Uncertain significance Single submitter
- ANO9 p.Leu647Phe Uncertain significance Single submitter
- ANO9 p.Lys593Arg Uncertain significance Single submitter
- ANO9 p.Lys734Thr Uncertain significance Single submitter
- ANO9 p.Met170Val Uncertain significance Single submitter
- ANO9 p.Met274Val Uncertain significance Single submitter
- ANO9 p.Met544Thr Uncertain significance Single submitter
- ANO9 p.Phe147Ser Uncertain significance Single submitter
- ANO9 p.Phe171Leu Uncertain significance Single submitter
- ANO9 p.Phe270Val Uncertain significance Single submitter
- ANO9 p.Phe430Val Uncertain significance Single submitter
- ANO9 p.Pro19Leu Uncertain significance Single submitter
- ANO9 p.Pro766Leu Uncertain significance Single submitter
- ANO9 p.Ser365Leu Uncertain significance Single submitter
- ANO9 p.Ser418Asn Uncertain significance Single submitter
- ANO9 p.Ser761Phe Uncertain significance Single submitter
- ANO9 p.Thr116Ala Uncertain significance Single submitter
- ANO9 p.Thr116Met Uncertain significance Single submitter
- ANO9 p.Thr132Ile Uncertain significance Single submitter
- ANO9 p.Thr279Met Uncertain significance Single submitter
- ANO9 p.Thr28Ile Uncertain significance Single submitter
- ANO9 p.Thr604Ile Uncertain significance Single submitter
- ANO9 p.Thr92Asn Uncertain significance Single submitter
- ANO9 p.Trp164Ser Uncertain significance Single submitter
- ANO9 p.Tyr494His Uncertain significance Single submitter
- ANO9 p.Val146Ile Uncertain significance Single submitter
- ANO9 p.Val192Ile Uncertain significance Single submitter
- ANO9 p.Val353Phe Uncertain significance Single submitter
- ANO9 p.Val356Ile Uncertain significance Single submitter
- ANO9 p.Val400Met Uncertain significance Single submitter
- ANO9 p.Val532Asp Uncertain significance Single submitter
- ANO9 p.Val675Met Uncertain significance Single submitter
- ANO9 p.Val712Met Uncertain significance Single submitter
- ANO9 p.Val724Met Uncertain significance Single submitter
- ANO9 p.Val731Gly Uncertain significance Single submitter
- ANO9 p.Val782Met Uncertain significance Single submitter
-
ANO9 p.Asp682Glu
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 16
The independent predictors disagree with each other — read with care.
- ANO9 p.Ala457Glu Uncertain significance Single submitter
- ANO9 p.Ala565Val Uncertain significance Single submitter
- ANO9 p.Arg172Pro Uncertain significance Single submitter
- ANO9 p.Arg321Trp Uncertain significance Single submitter
- ANO9 p.Arg49Trp Uncertain significance Single submitter
- ANO9 p.Asp47Glu Uncertain significance Single submitter
- ANO9 p.Asp539Gly Uncertain significance Single submitter
- ANO9 p.Glu307Gly Uncertain significance Single submitter
- ANO9 p.Gly135Ala Uncertain significance Single submitter
- ANO9 p.Leu206Pro Uncertain significance Single submitter
- ANO9 p.Phe413Leu Uncertain significance Single submitter
- ANO9 p.Phe77Leu Uncertain significance Single submitter
- ANO9 p.Pro531Leu Uncertain significance Single submitter
- ANO9 p.Ser642Tyr Uncertain significance Single submitter
- ANO9 p.Trp722Cys Uncertain significance Single submitter
- ANO9 p.Val378Met Uncertain significance Single submitter
All ANO9 variants
Benign 1
- p.Ile122= Multiple submitters
Likely benign 15
- c.1490+7G>A Single submitter
- p.Arg166Gln Single submitter
- p.Arg49Gln Single submitter
- p.Arg71Gln Single submitter
- p.Asp265Glu Single submitter
- p.Gln41= Single submitter
- p.Glu4Lys Single submitter
- p.Leu118Phe Single submitter
- p.Leu566= Single submitter
- p.Phe705= Single submitter
- p.Phe775Ser Single submitter
- p.Pro109= Single submitter
- p.Pro450= Single submitter
- p.Val332Ile Single submitter
- p.Val335Ile Single submitter
Uncertain significance 132
- p.Ala101Val Single submitter ⚠
- p.Ala104Thr Single submitter ⚠
- p.Ala108Thr Single submitter ⚠
- p.Ala221Ser Single submitter ⚠
- p.Ala275Pro Single submitter ⚠
- p.Ala30Ser Single submitter ⚠
- p.Ala30Thr Single submitter ⚠
- p.Ala360Val Single submitter ⚠
- p.Ala457Glu Single submitter ⚠
- p.Ala467Thr Single submitter ⚠
- p.Ala565Val Single submitter ⚠
- p.Ala609Val Single submitter ⚠
- p.Ala721Thr Single submitter
- p.Ala759Val Single submitter ⚠
- p.Ala767Thr Single submitter ⚠
- p.Arg121Gln Single submitter ⚠
- p.Arg159Cys Single submitter ⚠
- p.Arg172Pro Single submitter ⚠
- p.Arg172Trp Single submitter ⚠
- p.Arg244His Single submitter ⚠
- p.Arg248Gln Single submitter ⚠
- p.Arg291Cys Single submitter ⚠
- p.Arg291His Single submitter ⚠
- p.Arg321Gln Single submitter ⚠
- p.Arg321Leu Single submitter ⚠
- p.Arg321Trp Single submitter ⚠
- p.Arg355His Single submitter ⚠
- p.Arg423His Single submitter ⚠
- p.Arg42Cys Single submitter ⚠
- p.Arg455His Single submitter ⚠
- p.Arg49Trp Single submitter ⚠
- p.Arg524Trp Single submitter ⚠
- p.Arg684Cys Single submitter ⚠
- p.Arg702Leu Single submitter ⚠
- p.Arg742Thr Single submitter ⚠
- p.Arg744His Single submitter ⚠
- p.Arg744Ser Single submitter ⚠
- p.Arg762Trp Single submitter ⚠
- p.Arg81Cys Single submitter ⚠
- p.Arg8Trp Single submitter ⚠
- p.Asp233Asn Single submitter ⚠
- p.Asp233Gly Single submitter ⚠
- p.Asp47Glu Single submitter ⚠
- p.Asp539Asn Single submitter ⚠
- p.Asp539Gly Single submitter ⚠
- p.Asp726Gly Single submitter
- p.Asp83Asn Single submitter ⚠
- p.Cys315Tyr Single submitter ⚠
- p.Cys491Phe Single submitter ⚠
- p.Gln223His Single submitter ⚠
- p.Gln54Arg Single submitter ⚠
- p.Glu139Lys Single submitter ⚠
- p.Glu14Asp Single submitter ⚠
- p.Glu14Gln Single submitter ⚠
- p.Glu27Lys Single submitter ⚠
- p.Glu29Lys Single submitter ⚠
- p.Glu303Asp Single submitter ⚠
- p.Glu307Gly Single submitter ⚠
- p.Glu519Lys Single submitter ⚠
- p.Glu540Lys Single submitter ⚠
- p.Glu58Gln Single submitter ⚠
- p.Glu603Asp Single submitter
- p.Glu737Lys Single submitter ⚠
- p.Glu96Asp Single submitter ⚠
- p.Glu98Lys Single submitter ⚠
- p.Gly135Ala Single submitter ⚠
- p.Gly145Arg Single submitter ⚠
- p.Gly208Val Single submitter ⚠
- p.Gly215Arg Single submitter ⚠
- p.Gly240Arg Single submitter ⚠
- p.Gly346Ser Single submitter ⚠
- p.Gly451Arg Single submitter ⚠
- p.Gly451Trp Single submitter ⚠
- p.Gly649Val Single submitter ⚠
- p.Gly756Glu Single submitter ⚠
- p.His325Tyr Single submitter ⚠
- p.His659Gln Single submitter ⚠
- p.His749Arg Single submitter ⚠
- p.Ile624Thr Single submitter ⚠
- p.Leu206Pro Single submitter ⚠
- p.Leu239Val Single submitter ⚠
- p.Leu261Ile Single submitter ⚠
- p.Leu443Val Single submitter
- p.Leu560Pro Single submitter ⚠
- p.Leu560Val Single submitter ⚠
- p.Leu587Val Single submitter ⚠
- p.Leu608Arg Single submitter ⚠
- p.Leu608Val Single submitter ⚠
- p.Leu647Phe Single submitter ⚠
- p.Lys593Arg Single submitter ⚠
- p.Lys734Thr Single submitter ⚠
- p.Met170Val Single submitter ⚠
- p.Met274Val Single submitter ⚠
- p.Met544Thr Single submitter ⚠
- p.Met615Thr Single submitter
- p.Phe147Ser Single submitter ⚠
- p.Phe171Leu Single submitter ⚠
- p.Phe270Val Single submitter ⚠
- p.Phe413Leu Single submitter ⚠
- p.Phe430Val Single submitter ⚠
- p.Phe77Leu Single submitter ⚠
- p.Pro19Leu Single submitter ⚠
- p.Pro531Leu Single submitter ⚠
- p.Pro766Leu Single submitter ⚠
- p.Ser365Leu Single submitter ⚠
- p.Ser418Asn Single submitter ⚠
- p.Ser434Leu Single submitter
- p.Ser642Tyr Single submitter ⚠
- p.Ser761Phe Single submitter ⚠
- p.Thr116Ala Single submitter ⚠
- p.Thr116Met Single submitter ⚠
- p.Thr132Ile Single submitter ⚠
- p.Thr279Met Single submitter ⚠
- p.Thr28Ile Single submitter ⚠
- p.Thr604Ile Single submitter ⚠
- p.Thr92Asn Single submitter ⚠
- p.Trp164Ser Single submitter ⚠
- p.Trp722Cys Single submitter ⚠
- p.Tyr494His Single submitter ⚠
- p.Val146Ile Single submitter ⚠
- p.Val192Ile Single submitter ⚠
- p.Val353Phe Single submitter ⚠
- p.Val356Ile Single submitter ⚠
- p.Val378Met Single submitter ⚠
- p.Val400Met Single submitter ⚠
- p.Val532Asp Single submitter ⚠
- p.Val675Met Single submitter ⚠
- p.Val712Met Single submitter ⚠
- p.Val724Met Single submitter ⚠
- p.Val731Gly Single submitter ⚠
- p.Val782Met Single submitter ⚠
- p.Asp682Glu No assertion criteria prostate cancer ⚠