APLF — 70 ClinVar variants
All ClinVar germline APLF variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 68 flagged for review →
3 Likely benign · 67 Uncertain significance
Full APLF gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 68
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 54
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- APLF p.Ala17Pro Uncertain significance Single submitter
- APLF p.Ala19Thr Uncertain significance Single submitter
- APLF p.Arg10Leu Uncertain significance Single submitter
- APLF p.Arg182Lys Uncertain significance Single submitter
- APLF p.Arg293Lys Uncertain significance Single submitter
- APLF p.Arg99His Uncertain significance Single submitter
- APLF p.Arg99Leu Uncertain significance Single submitter
- APLF p.Asn161Asp Uncertain significance Single submitter
- APLF p.Asn169Asp Uncertain significance Single submitter
- APLF p.Asn431Ser Uncertain significance Single submitter
- APLF p.Asp259Glu Uncertain significance Single submitter
- APLF p.Asp334Asn Uncertain significance Single submitter
- APLF p.Cys111Arg Uncertain significance Single submitter
- APLF p.Cys427Arg Uncertain significance Single submitter
- APLF p.Gln117Lys Uncertain significance Single submitter
- APLF p.Gln156Glu Uncertain significance Single submitter
- APLF p.Gln175Arg Uncertain significance Single submitter
- APLF p.Gln230Arg Uncertain significance Single submitter
- APLF p.Gln71Leu Uncertain significance Single submitter
- APLF p.Glu147Lys Uncertain significance Single submitter
- APLF p.Glu193Gly Uncertain significance Single submitter
- APLF p.Glu339Gly Uncertain significance Single submitter
- APLF p.Gly167Ser Uncertain significance Single submitter
- APLF p.Gly21Glu Uncertain significance Single submitter
- APLF p.Gly252Arg Uncertain significance Single submitter
- APLF p.Gly252Glu Uncertain significance Single submitter
- APLF p.Gly333Arg Uncertain significance Single submitter
- APLF p.His58Tyr Uncertain significance Single submitter
- APLF p.Ile134Phe Uncertain significance Single submitter
- APLF p.Ile298Met Uncertain significance Single submitter
- APLF p.Leu166Pro Uncertain significance Single submitter
- APLF p.Leu200Ile Uncertain significance Single submitter
- APLF p.Leu200Val Uncertain significance Single submitter
- APLF p.Lys154Glu Uncertain significance Single submitter
- APLF p.Lys312Glu Uncertain significance Single submitter
- APLF p.Lys360Glu Uncertain significance Single submitter
- APLF p.Lys494Arg Uncertain significance Single submitter
- APLF p.Phe165Ser Uncertain significance Single submitter
- APLF p.Pro129Ser Uncertain significance Single submitter
- APLF p.Pro297Leu Uncertain significance Single submitter
- APLF p.Pro315Arg Uncertain significance Single submitter
- APLF p.Pro425Leu Uncertain significance Single submitter
- APLF p.Pro9Ser Uncertain significance Single submitter
- APLF p.Ser149Ile Uncertain significance Single submitter
- APLF p.Ser214Gly Uncertain significance Single submitter
- APLF p.Ser246Pro Uncertain significance Single submitter
- APLF p.Thr128Ser Uncertain significance Single submitter
- APLF p.Thr140Ser Uncertain significance Single submitter
- APLF p.Thr264Pro Uncertain significance Single submitter
- APLF p.Thr442Lys Uncertain significance Single submitter
- APLF p.Tyr82His Uncertain significance Single submitter
- APLF p.Val410Leu Uncertain significance Single submitter
- APLF p.Val445Gly Uncertain significance Single submitter
- APLF p.Val93Ile Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- APLF p.Arg418Trp Uncertain significance Single submitter
- APLF p.Asp450Gly Uncertain significance Single submitter
- APLF p.Gln65Glu Uncertain significance Single submitter
- APLF p.Gln71Arg Uncertain significance Single submitter
- APLF p.Ile25Met Uncertain significance Single submitter
- APLF p.Ile54Val Uncertain significance Single submitter
- APLF p.Leu125Trp Uncertain significance Single submitter
- APLF p.Leu18Pro Uncertain significance Single submitter
- APLF p.Phe468Ser Uncertain significance Single submitter
- APLF p.Pro74Leu Uncertain significance Single submitter
- APLF p.Ser347Phe Uncertain significance Single submitter
- APLF p.Ser67Leu Uncertain significance Single submitter
- APLF p.Thr23Ala Uncertain significance Single submitter
- APLF p.Val410Met Likely benign Single submitter
All APLF variants
Likely benign 3
- p.Arg99Cys Single submitter
- p.Thr442= Single submitter
- p.Val410Met Single submitter ⚠
Uncertain significance 67
- p.Ala17Pro Single submitter ⚠
- p.Ala19Thr Single submitter ⚠
- p.Arg10Leu Single submitter ⚠
- p.Arg182Lys Single submitter ⚠
- p.Arg293Lys Single submitter ⚠
- p.Arg418Trp Single submitter ⚠
- p.Arg99His Single submitter ⚠
- p.Arg99Leu Single submitter ⚠
- p.Asn161Asp Single submitter ⚠
- p.Asn169Asp Single submitter ⚠
- p.Asn431Ser Single submitter ⚠
- p.Asp259Glu Single submitter ⚠
- p.Asp334Asn Single submitter ⚠
- p.Asp450Gly Single submitter ⚠
- p.Cys111Arg Single submitter ⚠
- p.Cys427Arg Single submitter ⚠
- p.Gln117Lys Single submitter ⚠
- p.Gln156Glu Single submitter ⚠
- p.Gln175Arg Single submitter ⚠
- p.Gln230Arg Single submitter ⚠
- p.Gln65Glu Single submitter ⚠
- p.Gln71Arg Single submitter ⚠
- p.Gln71Leu Single submitter ⚠
- p.Glu147Lys Single submitter ⚠
- p.Glu193Gly Single submitter ⚠
- p.Glu339Gly Single submitter ⚠
- p.Gly167Ser Single submitter ⚠
- p.Gly21Glu Single submitter ⚠
- p.Gly252Arg Single submitter ⚠
- p.Gly252Glu Single submitter ⚠
- p.Gly333Arg Single submitter ⚠
- p.His58Tyr Single submitter ⚠
- p.Ile134Phe Single submitter ⚠
- p.Ile25Met Single submitter ⚠
- p.Ile298Met Single submitter ⚠
- p.Ile54Val Single submitter ⚠
- p.Leu125Trp Single submitter ⚠
- p.Leu166Pro Single submitter ⚠
- p.Leu18Pro Single submitter ⚠
- p.Leu200Ile Single submitter ⚠
- p.Leu200Val Single submitter ⚠
- p.Lys154Glu Single submitter ⚠
- p.Lys312Glu Single submitter ⚠
- p.Lys360Glu Single submitter ⚠
- p.Lys494Arg Single submitter ⚠
- p.Phe165Ser Single submitter ⚠
- p.Phe468Ser Single submitter ⚠
- p.Pro129Ser Single submitter ⚠
- p.Pro297Leu Single submitter ⚠
- p.Pro315Arg Single submitter ⚠
- p.Pro425Leu Single submitter ⚠
- p.Pro74Leu Single submitter ⚠
- p.Pro9Ser Single submitter ⚠
- p.Ser149Ile Single submitter ⚠
- p.Ser214Gly Single submitter ⚠
- p.Ser246Pro Single submitter ⚠
- p.Ser347Phe Single submitter ⚠
- p.Ser67Leu Single submitter ⚠
- p.Thr128Ser Single submitter ⚠
- p.Thr140Ser Single submitter ⚠
- p.Thr23Ala Single submitter ⚠
- p.Thr264Pro Single submitter ⚠
- p.Thr442Lys Single submitter ⚠
- p.Tyr82His Single submitter ⚠
- p.Val410Leu Single submitter ⚠
- p.Val445Gly Single submitter ⚠
- p.Val93Ile Single submitter ⚠