APMAP — 79 ClinVar variants
All ClinVar germline APMAP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 79 flagged for review →
79 Uncertain significance
Full APMAP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 79
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- APMAP p.Arg134Gln Uncertain significance Single submitter
- APMAP p.Arg143Gly Uncertain significance Single submitter
- APMAP p.Arg324Cys Uncertain significance Single submitter
- APMAP p.Arg343Gly Uncertain significance Single submitter
- APMAP p.Arg360Gln Uncertain significance Single submitter
- APMAP p.Arg360Pro Uncertain significance Single submitter
- APMAP p.Arg374Gln Uncertain significance Single submitter
- APMAP p.Asp167Asn Uncertain significance Single submitter
- APMAP p.Asp21Glu Uncertain significance Single submitter
- APMAP p.Asp5Ala Uncertain significance Single submitter
- APMAP p.Gln98Lys Uncertain significance Single submitter
- APMAP p.Glu189Gln Uncertain significance Single submitter
- APMAP p.Glu189Lys Uncertain significance Single submitter
- APMAP p.Glu232Gly Uncertain significance Single submitter
- APMAP p.Gly154Ser Uncertain significance Single submitter
- APMAP p.Gly261Arg Uncertain significance Single submitter
- APMAP p.Gly31Ala Uncertain significance Single submitter
- APMAP p.Gly371Asp Uncertain significance Single submitter
- APMAP p.Ile212Ser Uncertain significance Single submitter
- APMAP p.Leu50Val Uncertain significance Single submitter
- APMAP p.Leu70Ile Uncertain significance Single submitter
- APMAP p.Leu70Phe Uncertain significance Single submitter
- APMAP p.Leu88Pro Uncertain significance Single submitter
- APMAP p.Met301Ile Uncertain significance Single submitter
- APMAP p.Met58Thr Uncertain significance Single submitter
- APMAP p.Phe113Cys Uncertain significance Single submitter
- APMAP p.Phe297Leu Uncertain significance Single submitter
- APMAP p.Pro102Arg Uncertain significance Single submitter
- APMAP p.Pro12Thr Uncertain significance Single submitter
- APMAP p.Pro259Leu Uncertain significance Single submitter
- APMAP p.Pro325Ala Uncertain significance Single submitter
- APMAP p.Ser362Asn Uncertain significance Single submitter
- APMAP p.Ser370Asn Uncertain significance Single submitter
- APMAP p.Trp221Leu Uncertain significance Single submitter
- APMAP p.Val17Ala Uncertain significance Single submitter
- APMAP p.Val48Ile Uncertain significance Single submitter
- APMAP p.Val48Phe Uncertain significance Single submitter
Predictors split 42
The independent predictors disagree with each other — read with care.
- APMAP p.Ala47Gly Uncertain significance Single submitter
- APMAP p.Arg120Trp Uncertain significance Single submitter
- APMAP p.Arg134Pro Uncertain significance Single submitter
- APMAP p.Arg156Cys Uncertain significance Single submitter
- APMAP p.Arg156His Uncertain significance Single submitter
- APMAP p.Arg224Gln Uncertain significance Single submitter
- APMAP p.Arg238Cys Uncertain significance Single submitter
- APMAP p.Arg360Trp Uncertain significance Single submitter
- APMAP p.Arg89Gly Uncertain significance Single submitter
- APMAP p.Arg89Pro Uncertain significance Single submitter
- APMAP p.Asn126Ser Uncertain significance Single submitter
- APMAP p.Asn126Tyr Uncertain significance Single submitter
- APMAP p.Asn85Asp Uncertain significance Single submitter
- APMAP p.Asp216Asn Uncertain significance Single submitter
- APMAP p.Asp243His Uncertain significance Single submitter
- APMAP p.Glu241Gly Uncertain significance Single submitter
- APMAP p.Glu248Asp Uncertain significance Single submitter
- APMAP p.Gly233Cys Uncertain significance Single submitter
- APMAP p.Gly314Arg Uncertain significance Single submitter
- APMAP p.Gly371Cys Uncertain significance Single submitter
- APMAP p.Gly371Ser Uncertain significance Single submitter
- APMAP p.Ile105Met Uncertain significance Single submitter
- APMAP p.Leu253Ser Uncertain significance Single submitter
- APMAP p.Leu78Ser Uncertain significance Single submitter
- APMAP p.Lys220Gln Uncertain significance Single submitter
- APMAP p.Met301Val Uncertain significance Single submitter
- APMAP p.Pro12Leu Uncertain significance Single submitter
- APMAP p.Pro139Leu Uncertain significance Single submitter
- APMAP p.Pro147Leu Uncertain significance Single submitter
- APMAP p.Pro177Thr Uncertain significance Single submitter
- APMAP p.Pro69Arg Uncertain significance Single submitter
- APMAP p.Ser137Leu Uncertain significance Single submitter
- APMAP p.Ser2Asn Uncertain significance Single submitter
- APMAP p.Ser312Ile Uncertain significance Single submitter
- APMAP p.Ser33Phe Uncertain significance Single submitter
- APMAP p.Thr162Ile Uncertain significance Single submitter
- APMAP p.Thr322Asn Uncertain significance Single submitter
- APMAP p.Thr86Met Uncertain significance Single submitter
- APMAP p.Tyr361Cys Uncertain significance Single submitter
- APMAP p.Val122Ile Uncertain significance Single submitter
- APMAP p.Val18Ile Uncertain significance Single submitter
- APMAP p.Val52Ile Uncertain significance Single submitter
All APMAP variants
Uncertain significance 79
- p.Ala47Gly Single submitter ⚠
- p.Arg120Trp Single submitter ⚠
- p.Arg134Gln Single submitter ⚠
- p.Arg134Pro Single submitter ⚠
- p.Arg143Gly Single submitter ⚠
- p.Arg156Cys Single submitter ⚠
- p.Arg156His Single submitter ⚠
- p.Arg224Gln Single submitter ⚠
- p.Arg238Cys Single submitter ⚠
- p.Arg324Cys Single submitter ⚠
- p.Arg343Gly Single submitter ⚠
- p.Arg360Gln Single submitter ⚠
- p.Arg360Pro Single submitter ⚠
- p.Arg360Trp Single submitter ⚠
- p.Arg374Gln Single submitter ⚠
- p.Arg89Gly Single submitter ⚠
- p.Arg89Pro Single submitter ⚠
- p.Asn126Ser Single submitter ⚠
- p.Asn126Tyr Single submitter ⚠
- p.Asn85Asp Single submitter ⚠
- p.Asp167Asn Single submitter ⚠
- p.Asp216Asn Single submitter ⚠
- p.Asp21Glu Single submitter ⚠
- p.Asp243His Single submitter ⚠
- p.Asp5Ala Single submitter ⚠
- p.Gln98Lys Single submitter ⚠
- p.Glu189Gln Single submitter ⚠
- p.Glu189Lys Single submitter ⚠
- p.Glu232Gly Single submitter ⚠
- p.Glu241Gly Single submitter ⚠
- p.Glu248Asp Single submitter ⚠
- p.Gly154Ser Single submitter ⚠
- p.Gly233Cys Single submitter ⚠
- p.Gly261Arg Single submitter ⚠
- p.Gly314Arg Single submitter ⚠
- p.Gly31Ala Single submitter ⚠
- p.Gly371Asp Single submitter ⚠
- p.Gly371Cys Single submitter ⚠
- p.Gly371Ser Single submitter ⚠
- p.Ile105Met Single submitter ⚠
- p.Ile212Ser Single submitter ⚠
- p.Leu253Ser Single submitter ⚠
- p.Leu50Val Single submitter ⚠
- p.Leu70Ile Single submitter ⚠
- p.Leu70Phe Single submitter ⚠
- p.Leu78Ser Single submitter ⚠
- p.Leu88Pro Single submitter ⚠
- p.Lys220Gln Single submitter ⚠
- p.Met301Ile Single submitter ⚠
- p.Met301Val Single submitter ⚠
- p.Met58Thr Single submitter ⚠
- p.Phe113Cys Single submitter ⚠
- p.Phe297Leu Single submitter ⚠
- p.Pro102Arg Single submitter ⚠
- p.Pro12Leu Single submitter ⚠
- p.Pro12Thr Single submitter ⚠
- p.Pro139Leu Single submitter ⚠
- p.Pro147Leu Single submitter ⚠
- p.Pro177Thr Single submitter ⚠
- p.Pro259Leu Single submitter ⚠
- p.Pro325Ala Single submitter ⚠
- p.Pro69Arg Single submitter ⚠
- p.Ser137Leu Single submitter ⚠
- p.Ser2Asn Single submitter ⚠
- p.Ser312Ile Single submitter ⚠
- p.Ser33Phe Single submitter ⚠
- p.Ser362Asn Single submitter ⚠
- p.Ser370Asn Single submitter ⚠
- p.Thr162Ile Single submitter ⚠
- p.Thr322Asn Single submitter ⚠
- p.Thr86Met Single submitter ⚠
- p.Trp221Leu Single submitter ⚠
- p.Tyr361Cys Single submitter ⚠
- p.Val122Ile Single submitter ⚠
- p.Val17Ala Single submitter ⚠
- p.Val18Ile Single submitter ⚠
- p.Val48Ile Single submitter ⚠
- p.Val48Phe Single submitter ⚠
- p.Val52Ile Single submitter ⚠