APOBEC3D — 73 ClinVar variants
All ClinVar germline APOBEC3D variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 69 flagged for review →
4 Likely benign · 69 Uncertain significance
Full APOBEC3D gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 69
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- APOBEC3D p.Ala121Ser Uncertain significance Single submitter
- APOBEC3D p.Ala191Thr Uncertain significance Single submitter
- APOBEC3D p.Ala305Val Uncertain significance Single submitter
- APOBEC3D p.Arg144Gln Uncertain significance Single submitter
- APOBEC3D p.Arg195Cys Uncertain significance Single submitter
- APOBEC3D p.Arg226Gln Uncertain significance Single submitter
- APOBEC3D p.Arg246Leu Uncertain significance Single submitter
- APOBEC3D p.Arg265Met Uncertain significance Single submitter
- APOBEC3D p.Arg30Gln Uncertain significance Single submitter
- APOBEC3D p.Arg56Gln Uncertain significance Single submitter
- APOBEC3D p.Asn227Asp Uncertain significance Single submitter
- APOBEC3D p.Asp161Tyr Uncertain significance Single submitter
- APOBEC3D p.Asp19Asn Uncertain significance Single submitter
- APOBEC3D p.Asp256Asn Uncertain significance Single submitter
- APOBEC3D p.Cys261Ser Uncertain significance Single submitter
- APOBEC3D p.Glu228Lys Uncertain significance Single submitter
- APOBEC3D p.Glu236Gln Uncertain significance Single submitter
- APOBEC3D p.Glu295Asp Uncertain significance Single submitter
- APOBEC3D p.Glu302Asp Uncertain significance Single submitter
- APOBEC3D p.Glu329Lys Uncertain significance Single submitter
- APOBEC3D p.Gly225Asp Uncertain significance Single submitter
- APOBEC3D p.His240Arg Uncertain significance Single submitter
- APOBEC3D p.His240Tyr Uncertain significance Single submitter
- APOBEC3D p.Leu120Ser Uncertain significance Single submitter
- APOBEC3D p.Lys115Arg Uncertain significance Single submitter
- APOBEC3D p.Lys365Glu Uncertain significance Single submitter
- APOBEC3D p.Phe119Ser Uncertain significance Single submitter
- APOBEC3D p.Phe245Val Uncertain significance Single submitter
- APOBEC3D p.Phe83Cys Uncertain significance Single submitter
- APOBEC3D p.Pro58Leu Uncertain significance Single submitter
- APOBEC3D p.Ser65Leu Uncertain significance Single submitter
- APOBEC3D p.Thr196Met Uncertain significance Single submitter
- APOBEC3D p.Thr280Ala Uncertain significance Single submitter
- APOBEC3D p.Trp145Cys Uncertain significance Single submitter
- APOBEC3D p.Trp145Gly Uncertain significance Single submitter
- APOBEC3D p.Trp145Ser Uncertain significance Single submitter
Predictors split 33
The independent predictors disagree with each other — read with care.
- APOBEC3D p.Ala133Thr Uncertain significance Single submitter
- APOBEC3D p.Ala263Val Uncertain significance Single submitter
- APOBEC3D p.Ala79Pro Uncertain significance Single submitter
- APOBEC3D p.Arg11Gln Uncertain significance Single submitter
- APOBEC3D p.Arg134Cys Uncertain significance Single submitter
- APOBEC3D p.Arg156Cys Uncertain significance Single submitter
- APOBEC3D p.Arg74Trp Uncertain significance Single submitter
- APOBEC3D p.Asn125Lys Uncertain significance Single submitter
- APOBEC3D p.Asn125Ser Uncertain significance Single submitter
- APOBEC3D p.Asn189Ser Uncertain significance Single submitter
- APOBEC3D p.Cys293Phe Uncertain significance Single submitter
- APOBEC3D p.Cys320Arg Uncertain significance Single submitter
- APOBEC3D p.Gln328His Uncertain significance Single submitter
- APOBEC3D p.Gln336Leu Uncertain significance Single submitter
- APOBEC3D p.Glu122Gly Uncertain significance Single submitter
- APOBEC3D p.Glu170Ala Uncertain significance Single submitter
- APOBEC3D p.Glu264Lys Uncertain significance Single submitter
- APOBEC3D p.Gly177Arg Uncertain significance Single submitter
- APOBEC3D p.Gly330Arg Uncertain significance Single submitter
- APOBEC3D p.Gly330Glu Uncertain significance Single submitter
- APOBEC3D p.His262Tyr Uncertain significance Single submitter
- APOBEC3D p.Ile159Met Uncertain significance Single submitter
- APOBEC3D p.Ile343Phe Uncertain significance Single submitter
- APOBEC3D p.Ile384Ser Uncertain significance Single submitter
- APOBEC3D p.Leu201Arg Uncertain significance Single submitter
- APOBEC3D p.Leu201Phe Uncertain significance Single submitter
- APOBEC3D p.Met208Thr Uncertain significance Single submitter
- APOBEC3D p.Phe364Leu Uncertain significance Single submitter
- APOBEC3D p.Ser85Pro Uncertain significance Single submitter
- APOBEC3D p.Thr129Asn Uncertain significance Single submitter
- APOBEC3D p.Thr313Ile Uncertain significance Single submitter
- APOBEC3D p.Val250Leu Uncertain significance Single submitter
- APOBEC3D p.Val341Met Uncertain significance Single submitter
All APOBEC3D variants
Likely benign 4
- p.Arg246Trp Single submitter
- p.Arg63Leu Single submitter
- p.Arg74Gln Single submitter
- p.Cys332Arg Single submitter
Uncertain significance 69
- p.Ala121Ser Single submitter ⚠
- p.Ala133Thr Single submitter ⚠
- p.Ala191Thr Single submitter ⚠
- p.Ala263Val Single submitter ⚠
- p.Ala305Val Single submitter ⚠
- p.Ala79Pro Single submitter ⚠
- p.Arg11Gln Single submitter ⚠
- p.Arg134Cys Single submitter ⚠
- p.Arg144Gln Single submitter ⚠
- p.Arg156Cys Single submitter ⚠
- p.Arg195Cys Single submitter ⚠
- p.Arg226Gln Single submitter ⚠
- p.Arg246Leu Single submitter ⚠
- p.Arg265Met Single submitter ⚠
- p.Arg30Gln Single submitter ⚠
- p.Arg56Gln Single submitter ⚠
- p.Arg74Trp Single submitter ⚠
- p.Asn125Lys Single submitter ⚠
- p.Asn125Ser Single submitter ⚠
- p.Asn189Ser Single submitter ⚠
- p.Asn227Asp Single submitter ⚠
- p.Asp161Tyr Single submitter ⚠
- p.Asp19Asn Single submitter ⚠
- p.Asp256Asn Single submitter ⚠
- p.Cys261Ser Single submitter ⚠
- p.Cys293Phe Single submitter ⚠
- p.Cys320Arg Single submitter ⚠
- p.Gln328His Single submitter ⚠
- p.Gln336Leu Single submitter ⚠
- p.Glu122Gly Single submitter ⚠
- p.Glu170Ala Single submitter ⚠
- p.Glu228Lys Single submitter ⚠
- p.Glu236Gln Single submitter ⚠
- p.Glu264Lys Single submitter ⚠
- p.Glu295Asp Single submitter ⚠
- p.Glu302Asp Single submitter ⚠
- p.Glu329Lys Single submitter ⚠
- p.Gly177Arg Single submitter ⚠
- p.Gly225Asp Single submitter ⚠
- p.Gly330Arg Single submitter ⚠
- p.Gly330Glu Single submitter ⚠
- p.His240Arg Single submitter ⚠
- p.His240Tyr Single submitter ⚠
- p.His262Tyr Single submitter ⚠
- p.Ile159Met Single submitter ⚠
- p.Ile343Phe Single submitter ⚠
- p.Ile384Ser Single submitter ⚠
- p.Leu120Ser Single submitter ⚠
- p.Leu201Arg Single submitter ⚠
- p.Leu201Phe Single submitter ⚠
- p.Lys115Arg Single submitter ⚠
- p.Lys365Glu Single submitter ⚠
- p.Met208Thr Single submitter ⚠
- p.Phe119Ser Single submitter ⚠
- p.Phe245Val Single submitter ⚠
- p.Phe364Leu Single submitter ⚠
- p.Phe83Cys Single submitter ⚠
- p.Pro58Leu Single submitter ⚠
- p.Ser65Leu Single submitter ⚠
- p.Ser85Pro Single submitter ⚠
- p.Thr129Asn Single submitter ⚠
- p.Thr196Met Single submitter ⚠
- p.Thr280Ala Single submitter ⚠
- p.Thr313Ile Single submitter ⚠
- p.Trp145Cys Single submitter ⚠
- p.Trp145Gly Single submitter ⚠
- p.Trp145Ser Single submitter ⚠
- p.Val250Leu Single submitter ⚠
- p.Val341Met Single submitter ⚠