APOBEC3F — 66 ClinVar variants
All ClinVar germline APOBEC3F variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 58 flagged for review →
2 Benign · 1 Benign/Likely benign · 7 Likely benign · 56 Uncertain significance
Full APOBEC3F gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 58
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- APOBEC3F c.196G>C Uncertain significance Single submitter
- APOBEC3F p.Arg128Lys Uncertain significance Single submitter
- APOBEC3F p.Arg213Gln Uncertain significance Single submitter
- APOBEC3F p.Arg239Gln Uncertain significance Single submitter
- APOBEC3F p.Arg29Gly Uncertain significance Single submitter
- APOBEC3F p.Arg29His Uncertain significance Single submitter
- APOBEC3F p.Asp148Glu Uncertain significance Single submitter
- APOBEC3F p.Asp175Glu Uncertain significance Single submitter
- APOBEC3F p.Asp261Asn Uncertain significance Single submitter
- APOBEC3F p.Cys248Phe Uncertain significance Single submitter
- APOBEC3F p.Gln139Lys Uncertain significance Single submitter
- APOBEC3F p.Gln61Glu Uncertain significance Single submitter
- APOBEC3F p.Glu163Asp Uncertain significance Single submitter
- APOBEC3F p.Glu215Lys Uncertain significance Single submitter
- APOBEC3F p.Glu349Lys Uncertain significance Single submitter
- APOBEC3F p.Glu38Lys Uncertain significance Single submitter
- APOBEC3F p.Gly236Asp Uncertain significance Single submitter
- APOBEC3F p.Ile87Thr Uncertain significance Single submitter
- APOBEC3F p.Leu184Pro Uncertain significance Single submitter
- APOBEC3F p.Phe179Ser Uncertain significance Single submitter
- APOBEC3F p.Pro265Arg Uncertain significance Single submitter
- APOBEC3F p.Pro3Thr Uncertain significance Single submitter
- APOBEC3F p.Ser232Cys Uncertain significance Single submitter
- APOBEC3F p.Ser232Phe Uncertain significance Single submitter
- APOBEC3F p.Ser28Phe Uncertain significance Single submitter
- APOBEC3F p.Tyr59His Uncertain significance Single submitter
- APOBEC3F p.Val100Met Uncertain significance Single submitter
Predictors split 31
The independent predictors disagree with each other — read with care.
- APOBEC3F p.Tyr307Cys Benign Multiple submitters
- APOBEC3F p.Arg143His Uncertain significance Single submitter
- APOBEC3F p.Arg182His Uncertain significance Single submitter
- APOBEC3F p.Arg208Cys Uncertain significance Single submitter
- APOBEC3F p.Arg319Cys Uncertain significance Single submitter
- APOBEC3F p.Asp335Gly Uncertain significance Single submitter
- APOBEC3F p.Cys155Gly Uncertain significance Single submitter
- APOBEC3F p.Cys155Phe Uncertain significance Single submitter
- APOBEC3F p.Gly212Val Uncertain significance Single submitter
- APOBEC3F p.Gly332Ala Uncertain significance Single submitter
- APOBEC3F p.Gly56Asp Uncertain significance Single submitter
- APOBEC3F p.Lys337Gln Uncertain significance Single submitter
- APOBEC3F p.Met195Thr Likely benign Single submitter
- APOBEC3F p.Pro111His Uncertain significance Single submitter
- APOBEC3F p.Pro111Ser Uncertain significance Single submitter
- APOBEC3F p.Pro191Leu Uncertain significance Single submitter
- APOBEC3F p.Pro230Ala Uncertain significance Single submitter
- APOBEC3F p.Pro350Arg Uncertain significance Single submitter
- APOBEC3F p.Pro80Ser Uncertain significance Single submitter
- APOBEC3F p.Ser138Thr Uncertain significance Single submitter
- APOBEC3F p.Ser264Cys Uncertain significance Single submitter
- APOBEC3F p.Ser295Gly Uncertain significance Single submitter
- APOBEC3F p.Thr88Ile Uncertain significance Single submitter
- APOBEC3F p.Thr94Ala Uncertain significance Single submitter
- APOBEC3F p.Trp233Arg Uncertain significance Single submitter
- APOBEC3F p.Trp310Cys Uncertain significance Single submitter
- APOBEC3F p.Tyr161Cys Uncertain significance Single submitter
- APOBEC3F p.Tyr196Cys Uncertain significance Single submitter
- APOBEC3F p.Tyr308Cys Uncertain significance Single submitter
- APOBEC3F p.Tyr314Ser Uncertain significance Single submitter
- APOBEC3F p.Val144Leu Uncertain significance Single submitter
All APOBEC3F variants
Benign 2
- p.Pro191= Multiple submitters
- p.Tyr307Cys Multiple submitters ⚠
Benign/Likely benign 1
- p.Asn346Ser Multiple submitters
Likely benign 7
- p.Glu151Asp Multiple submitters
- p.Glu373Lys Multiple submitters
- p.Arg131Gln Single submitter
- p.Cys84Arg Single submitter
- p.Leu263= Single submitter
- p.Lys337Glu Single submitter
- p.Met195Thr Single submitter ⚠
Uncertain significance 56
- c.196G>C Single submitter ⚠
- p.Arg128Lys Single submitter ⚠
- p.Arg143His Single submitter ⚠
- p.Arg182His Single submitter ⚠
- p.Arg208Cys Single submitter ⚠
- p.Arg213Gln Single submitter ⚠
- p.Arg239Gln Single submitter ⚠
- p.Arg29Gly Single submitter ⚠
- p.Arg29His Single submitter ⚠
- p.Arg319Cys Single submitter ⚠
- p.Asp148Glu Single submitter ⚠
- p.Asp175Glu Single submitter ⚠
- p.Asp261Asn Single submitter ⚠
- p.Asp335Gly Single submitter ⚠
- p.Cys155Gly Single submitter ⚠
- p.Cys155Phe Single submitter ⚠
- p.Cys248Phe Single submitter ⚠
- p.Gln139Lys Single submitter ⚠
- p.Gln61Glu Single submitter ⚠
- p.Glu163Asp Single submitter ⚠
- p.Glu215Lys Single submitter ⚠
- p.Glu349Lys Single submitter ⚠
- p.Glu38Lys Single submitter ⚠
- p.Gly212Val Single submitter ⚠
- p.Gly236Asp Single submitter ⚠
- p.Gly332Ala Single submitter ⚠
- p.Gly56Asp Single submitter ⚠
- p.Ile87Thr Single submitter ⚠
- p.Leu184Pro Single submitter ⚠
- p.Lys337Gln Single submitter ⚠
- p.Phe179Ser Single submitter ⚠
- p.Pro111His Single submitter ⚠
- p.Pro111Ser Single submitter ⚠
- p.Pro191Leu Single submitter ⚠
- p.Pro230Ala Single submitter ⚠
- p.Pro265Arg Single submitter ⚠
- p.Pro350Arg Single submitter ⚠
- p.Pro3Thr Single submitter ⚠
- p.Pro80Ser Single submitter ⚠
- p.Ser138Thr Single submitter ⚠
- p.Ser232Cys Single submitter ⚠
- p.Ser232Phe Single submitter ⚠
- p.Ser264Cys Single submitter ⚠
- p.Ser28Phe Single submitter ⚠
- p.Ser295Gly Single submitter ⚠
- p.Thr88Ile Single submitter ⚠
- p.Thr94Ala Single submitter ⚠
- p.Trp233Arg Single submitter ⚠
- p.Trp310Cys Single submitter ⚠
- p.Tyr161Cys Single submitter ⚠
- p.Tyr196Cys Single submitter ⚠
- p.Tyr308Cys Single submitter ⚠
- p.Tyr314Ser Single submitter ⚠
- p.Tyr59His Single submitter ⚠
- p.Val100Met Single submitter ⚠
- p.Val144Leu Single submitter ⚠