APOBR — 100 ClinVar variants

All ClinVar germline APOBR variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 79 flagged for review →

2 Benign · 23 Likely benign · 75 Uncertain significance

Full APOBR gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 79

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 43

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 36

The independent predictors disagree with each other — read with care.

All APOBR variants

Benign 2

p.Gln807Pro Multiple submitters
p.352EEAGTASGG[1] Single submitter

Likely benign 23

p.Gly350= Multiple submitters
p.Ala196Val Single submitter
p.Ala328= Single submitter
p.Ala345= Single submitter
p.Ala354= Single submitter
p.Ala518= Single submitter
p.Ala799Val Single submitter
p.Gln150Arg Single submitter
p.Glu242Lys Single submitter ⚠
p.Glu311= Single submitter
p.Glu578Lys Single submitter ⚠
p.Glu794Gly Single submitter
p.Gly154Ser Single submitter
p.Gly204Arg Single submitter
p.Gly23Ser Single submitter
p.Gly315= Single submitter
p.Gly316Arg Single submitter ⚠
p.Gly329= Single submitter
p.Ile339Thr Single submitter
p.Pro287Ser Single submitter
p.Ser332= Single submitter
p.Ser831Phe Single submitter ⚠
p.Thr123Ala Single submitter

Uncertain significance 75

p.Ala241Gly Single submitter ⚠
p.Ala283Val Single submitter ⚠
p.Ala292Val Single submitter ⚠
p.Ala301Thr Single submitter ⚠
p.Ala33Val Single submitter ⚠
p.Ala514Asp Single submitter ⚠
p.Ala540Thr Single submitter ⚠
p.Ala619Val Single submitter ⚠
p.Ala686Ser Single submitter ⚠
p.Ala730Pro Single submitter ⚠
p.Ala746Val Single submitter ⚠
p.Ala849Val Single submitter ⚠
p.Ala958Thr Single submitter ⚠
p.Ala980Val Single submitter ⚠
p.Arg16Thr Single submitter ⚠
p.Arg222Gln Single submitter ⚠
p.Arg39Leu Single submitter ⚠
p.Arg39Trp Single submitter ⚠
p.Arg5Trp Single submitter ⚠
p.Arg734Ser Single submitter ⚠
p.Asp151Tyr Single submitter ⚠
p.Asp856Asn Single submitter ⚠
p.Asp918Asn Single submitter ⚠
p.Cys257Phe Single submitter ⚠
p.Gln155His Single submitter ⚠
p.Gln74His Single submitter ⚠
p.Gln756His Single submitter ⚠
p.Glu161Asp Single submitter ⚠
p.Glu179Gly Single submitter ⚠
p.Glu181Asp Single submitter ⚠
p.Glu207Asp Single submitter ⚠
p.Glu300Gln Single submitter ⚠
p.Glu371Gln Single submitter ⚠
p.Glu412Lys Single submitter ⚠
p.Glu645Lys Single submitter ⚠
p.Glu65Lys Single submitter ⚠
p.Glu802Asp Single submitter ⚠
p.Glu818Asp Single submitter ⚠
p.Gly104Arg Single submitter ⚠
p.Gly195Glu Single submitter ⚠
p.Gly214Glu Single submitter ⚠
p.Gly23Arg Single submitter ⚠
p.Gly243Glu Single submitter ⚠
p.Gly279Ser Single submitter ⚠
p.Gly298Arg Single submitter ⚠
p.Gly307Arg Single submitter ⚠
p.Gly329Arg Single submitter ⚠
p.Gly329Glu Single submitter ⚠
p.Gly355Arg Single submitter ⚠
p.Gly622Arg Single submitter ⚠
p.Gly664Arg Single submitter ⚠
p.Gly758Asp Single submitter ⚠
p.Gly977Arg Single submitter ⚠
p.Ile58Thr Single submitter ⚠
p.Leu29Phe Single submitter ⚠
p.Leu992Phe Single submitter ⚠
p.Leu993Pro Single submitter ⚠
p.Lys54Asn Single submitter ⚠
p.Met632Ile Single submitter ⚠
p.Pro1055Leu Single submitter ⚠
p.Pro35Thr Single submitter ⚠
p.Pro674Gln Single submitter ⚠
p.Pro950Leu Single submitter ⚠
p.Ser111Cys Single submitter ⚠
p.Ser601Asn Single submitter ⚠
p.Ser996Phe Single submitter ⚠
p.Thr100Ile Single submitter ⚠
p.Thr201Asn Single submitter ⚠
p.Thr206Met Single submitter ⚠
p.Thr265Met Single submitter ⚠
p.Thr303Arg Single submitter ⚠
p.Thr935Ala Single submitter ⚠
p.Val421Leu Single submitter ⚠
p.Val769Met Single submitter ⚠
p.Val963Ala Single submitter ⚠