APOL2 — 83 ClinVar variants
All ClinVar germline APOL2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 75 flagged for review →
1 Benign · 8 Likely benign · 74 Uncertain significance
Full APOL2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 75
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- APOL2 p.Ala179Val Uncertain significance Single submitter
- APOL2 p.Ala238Thr Uncertain significance Single submitter
- APOL2 p.Ala240Asp Uncertain significance Single submitter
- APOL2 p.Ala265Val Uncertain significance Single submitter
- APOL2 p.Arg100His Uncertain significance Single submitter
- APOL2 p.Arg248Gln Uncertain significance Single submitter
- APOL2 p.Arg46Gly Uncertain significance Single submitter
- APOL2 p.Arg46Ser Uncertain significance Single submitter
- APOL2 p.Arg70His Uncertain significance Single submitter
- APOL2 p.Arg70Leu Uncertain significance Single submitter
- APOL2 p.Arg90Thr Uncertain significance Single submitter
- APOL2 p.Asn69Ile Uncertain significance Single submitter
- APOL2 p.Asn69Lys Uncertain significance Single submitter
- APOL2 p.Asp18Glu Uncertain significance Single submitter
- APOL2 p.Asp32Asn Uncertain significance Single submitter
- APOL2 p.Asp47Asn Uncertain significance Single submitter
- APOL2 p.Asp67Glu Uncertain significance Single submitter
- APOL2 p.Asp74Glu Uncertain significance Single submitter
- APOL2 p.Gln27His Uncertain significance Single submitter
- APOL2 p.Gln27Leu Uncertain significance Single submitter
- APOL2 p.Gln79Arg Uncertain significance Single submitter
- APOL2 p.Glu197Asp Uncertain significance Single submitter
- APOL2 p.Gly156Glu Uncertain significance Single submitter
- APOL2 p.Gly254Ser Uncertain significance Single submitter
- APOL2 p.His244Arg Uncertain significance Single submitter
- APOL2 p.Ile249Thr Uncertain significance Single submitter
- APOL2 p.Lys68Glu Uncertain significance Single submitter
- APOL2 p.Met153Val Uncertain significance Single submitter
- APOL2 p.Met330Leu Uncertain significance Single submitter
- APOL2 p.Met63Ile Uncertain significance Single submitter
- APOL2 p.Pro243Thr Uncertain significance Single submitter
- APOL2 p.Pro264Leu Uncertain significance Single submitter
- APOL2 p.Ser167Asn Uncertain significance Single submitter
- APOL2 p.Ser269Gly Uncertain significance Single submitter
- APOL2 p.Thr189Ala Uncertain significance Single submitter
- APOL2 p.Thr189Ile Uncertain significance Single submitter
- APOL2 p.Thr203Ala Uncertain significance Single submitter
- APOL2 p.Thr203Ser Uncertain significance Single submitter
- APOL2 p.Thr208Ile Uncertain significance Single submitter
- APOL2 p.Thr208Pro Uncertain significance Single submitter
- APOL2 p.Thr217Ile Uncertain significance Single submitter
- APOL2 p.Thr279Ile Uncertain significance Single submitter
- APOL2 p.Val206Ala Uncertain significance Single submitter
Predictors split 32
The independent predictors disagree with each other — read with care.
- APOL2 p.Arg53His Uncertain significance Multiple submitters
- APOL2 p.Ala159Thr Likely benign Single submitter
- APOL2 p.Ala314Val Uncertain significance Single submitter
- APOL2 p.Arg100Cys Uncertain significance Single submitter
- APOL2 p.Arg100Gly Uncertain significance Single submitter
- APOL2 p.Arg176Pro Uncertain significance Single submitter
- APOL2 p.Arg176Trp Uncertain significance Single submitter
- APOL2 p.Arg225Cys Uncertain significance Single submitter
- APOL2 p.Arg225His Uncertain significance Single submitter
- APOL2 p.Arg225Pro Uncertain significance Single submitter
- APOL2 p.Arg53Cys Uncertain significance Single submitter
- APOL2 p.Arg87Pro Uncertain significance Single submitter
- APOL2 p.Arg87Trp Uncertain significance Single submitter
- APOL2 p.Asn173Asp Uncertain significance Single submitter
- APOL2 p.Asp94Gly Uncertain significance Single submitter
- APOL2 p.Glu23Lys Uncertain significance Single submitter
- APOL2 p.Gly152Val Uncertain significance Single submitter
- APOL2 p.Gly281Val Uncertain significance Single submitter
- APOL2 p.Ile164Phe Uncertain significance Single submitter
- APOL2 p.Leu310Pro Uncertain significance Single submitter
- APOL2 p.Leu324Val Uncertain significance Single submitter
- APOL2 p.Leu52Phe Uncertain significance Single submitter
- APOL2 p.Leu52Pro Uncertain significance Single submitter
- APOL2 p.Pro86Ser Uncertain significance Single submitter
- APOL2 p.Ser127Thr Uncertain significance Single submitter
- APOL2 p.Ser145Asn Uncertain significance Single submitter
- APOL2 p.Thr114Ile Uncertain significance Single submitter
- APOL2 p.Thr126Asn Uncertain significance Single submitter
- APOL2 p.Thr131Ser Likely benign Single submitter
- APOL2 p.Thr272Asn Uncertain significance Single submitter
- APOL2 p.Thr279Pro Uncertain significance Single submitter
- APOL2 p.Val20Gly Uncertain significance Single submitter
All APOL2 variants
Benign 1
- p.Arg78Lys Multiple submitters
Likely benign 8
- p.Ala159Thr Single submitter ⚠
- p.Ala162Thr Single submitter
- p.Arg259Lys Single submitter
- p.Arg313Gln Single submitter
- p.Asp150Ala Single submitter
- p.Gln108= Single submitter
- p.Gln180Glu Single submitter
- p.Thr131Ser Single submitter ⚠
Uncertain significance 74
- p.Arg53His Multiple submitters ⚠
- c.11-1G>C Single submitter
- p.Ala179Val Single submitter ⚠
- p.Ala238Thr Single submitter ⚠
- p.Ala240Asp Single submitter ⚠
- p.Ala265Val Single submitter ⚠
- p.Ala314Val Single submitter ⚠
- p.Arg100Cys Single submitter ⚠
- p.Arg100Gly Single submitter ⚠
- p.Arg100His Single submitter ⚠
- p.Arg176Pro Single submitter ⚠
- p.Arg176Trp Single submitter ⚠
- p.Arg225Cys Single submitter ⚠
- p.Arg225His Single submitter ⚠
- p.Arg225Pro Single submitter ⚠
- p.Arg248Gln Single submitter ⚠
- p.Arg46Gly Single submitter ⚠
- p.Arg46Ser Single submitter ⚠
- p.Arg53Cys Single submitter ⚠
- p.Arg70His Single submitter ⚠
- p.Arg70Leu Single submitter ⚠
- p.Arg87Pro Single submitter ⚠
- p.Arg87Trp Single submitter ⚠
- p.Arg90Thr Single submitter ⚠
- p.Asn173Asp Single submitter ⚠
- p.Asn69Ile Single submitter ⚠
- p.Asn69Lys Single submitter ⚠
- p.Asp18Glu Single submitter ⚠
- p.Asp32Asn Single submitter ⚠
- p.Asp47Asn Single submitter ⚠
- p.Asp67Glu Single submitter ⚠
- p.Asp74Glu Single submitter ⚠
- p.Asp94Gly Single submitter ⚠
- p.Gln27His Single submitter ⚠
- p.Gln27Leu Single submitter ⚠
- p.Gln79Arg Single submitter ⚠
- p.Glu197Asp Single submitter ⚠
- p.Glu23Lys Single submitter ⚠
- p.Gly152Val Single submitter ⚠
- p.Gly156Glu Single submitter ⚠
- p.Gly254Ser Single submitter ⚠
- p.Gly281Val Single submitter ⚠
- p.His244Arg Single submitter ⚠
- p.Ile164Phe Single submitter ⚠
- p.Ile249Thr Single submitter ⚠
- p.Leu310Pro Single submitter ⚠
- p.Leu324Val Single submitter ⚠
- p.Leu52Phe Single submitter ⚠
- p.Leu52Pro Single submitter ⚠
- p.Lys68Glu Single submitter ⚠
- p.Met153Val Single submitter ⚠
- p.Met330Leu Single submitter ⚠
- p.Met63Ile Single submitter ⚠
- p.Pro243Thr Single submitter ⚠
- p.Pro264Leu Single submitter ⚠
- p.Pro86Ser Single submitter ⚠
- p.Ser127Thr Single submitter ⚠
- p.Ser145Asn Single submitter ⚠
- p.Ser167Asn Single submitter ⚠
- p.Ser269Gly Single submitter ⚠
- p.Thr114Ile Single submitter ⚠
- p.Thr126Asn Single submitter ⚠
- p.Thr189Ala Single submitter ⚠
- p.Thr189Ile Single submitter ⚠
- p.Thr203Ala Single submitter ⚠
- p.Thr203Ser Single submitter ⚠
- p.Thr208Ile Single submitter ⚠
- p.Thr208Pro Single submitter ⚠
- p.Thr217Ile Single submitter ⚠
- p.Thr272Asn Single submitter ⚠
- p.Thr279Ile Single submitter ⚠
- p.Thr279Pro Single submitter ⚠
- p.Val206Ala Single submitter ⚠
- p.Val20Gly Single submitter ⚠