APOLD1 — 57 ClinVar variants
All ClinVar germline APOLD1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 57 flagged for review →
57 Uncertain significance
Full APOLD1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 57
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- APOLD1 p.Ala159Val Uncertain significance Single submitter
- APOLD1 p.Ala244Thr Uncertain significance Single submitter
- APOLD1 p.Ala67Ser Uncertain significance Single submitter
- APOLD1 p.Arg132Leu Uncertain significance Single submitter
- APOLD1 p.Arg150Leu Uncertain significance Single submitter
- APOLD1 p.Arg150Ser Uncertain significance Single submitter
- APOLD1 p.Arg157Lys Uncertain significance Single submitter
- APOLD1 p.Arg232Gly Uncertain significance Single submitter
- APOLD1 p.Arg43Gly Uncertain significance Single submitter
- APOLD1 p.Asp214Gly Uncertain significance Single submitter
- APOLD1 p.Asp235Val Uncertain significance Single submitter
- APOLD1 p.Gln151His Uncertain significance Single submitter
- APOLD1 p.Gln21Arg Uncertain significance Single submitter
- APOLD1 p.Glu122Gly Uncertain significance Single submitter
- APOLD1 p.Glu218Lys Uncertain significance Single submitter
- APOLD1 p.Gly148Glu Uncertain significance Single submitter
- APOLD1 p.Gly211Arg Uncertain significance Single submitter
- APOLD1 p.Gly22Arg Uncertain significance Single submitter
- APOLD1 p.Gly59Arg Uncertain significance Single submitter
- APOLD1 p.Gly59Cys Uncertain significance Single submitter
- APOLD1 p.Gly73Val Uncertain significance Single submitter
- APOLD1 p.His32Leu Uncertain significance Single submitter
- APOLD1 p.Leu117Met Uncertain significance Single submitter
- APOLD1 p.Leu216Phe Uncertain significance Single submitter
- APOLD1 p.Leu23Val Uncertain significance Single submitter
- APOLD1 p.Leu24Met Uncertain significance Single submitter
- APOLD1 p.Leu53Val Uncertain significance Single submitter
- APOLD1 p.Lys229Asn Uncertain significance Single submitter
- APOLD1 p.Phe247Leu Uncertain significance Single submitter
- APOLD1 p.Phe248Val Uncertain significance Single submitter
- APOLD1 p.Pro6Thr Uncertain significance Single submitter
- APOLD1 p.Ser205Asn Uncertain significance Single submitter
- APOLD1 p.Thr126Ala Uncertain significance Single submitter
Predictors split 24
The independent predictors disagree with each other — read with care.
- APOLD1 p.Ala42Pro Uncertain significance Single submitter
- APOLD1 p.Arg18Trp Uncertain significance Single submitter
- APOLD1 p.Arg19His Uncertain significance Single submitter
- APOLD1 p.Arg19Ser Uncertain significance Single submitter
- APOLD1 p.Arg43Pro Uncertain significance Single submitter
- APOLD1 p.Arg49Ser Uncertain significance Single submitter
- APOLD1 p.Arg5Lys Uncertain significance Single submitter
- APOLD1 p.Cys137Ser Uncertain significance Single submitter
- APOLD1 p.Gln225His Uncertain significance Single submitter
- APOLD1 p.Glu10Lys Uncertain significance Single submitter
- APOLD1 p.Glu207Lys Uncertain significance Single submitter
- APOLD1 p.Gly13Val Uncertain significance Single submitter
- APOLD1 p.Gly33Val Uncertain significance Single submitter
- APOLD1 p.Gly59Ser Uncertain significance Single submitter
- APOLD1 p.Gly66Ala Uncertain significance Single submitter
- APOLD1 p.Leu25Pro Uncertain significance Single submitter
- APOLD1 p.Leu45Pro Uncertain significance Single submitter
- APOLD1 p.Phe20Leu Uncertain significance Single submitter
- APOLD1 p.Ser191Arg Uncertain significance Single submitter
- APOLD1 p.Ser61Leu Uncertain significance Single submitter
- APOLD1 p.Ser61Pro Uncertain significance Single submitter
- APOLD1 p.Ser63Arg Uncertain significance Single submitter
- APOLD1 p.Thr65Lys Uncertain significance Single submitter
- APOLD1 p.Val72Met Uncertain significance Single submitter
All APOLD1 variants
Uncertain significance 57
- p.Ala159Val Single submitter ⚠
- p.Ala244Thr Single submitter ⚠
- p.Ala42Pro Single submitter ⚠
- p.Ala67Ser Single submitter ⚠
- p.Arg132Leu Single submitter ⚠
- p.Arg150Leu Single submitter ⚠
- p.Arg150Ser Single submitter ⚠
- p.Arg157Lys Single submitter ⚠
- p.Arg18Trp Single submitter ⚠
- p.Arg19His Single submitter ⚠
- p.Arg19Ser Single submitter ⚠
- p.Arg232Gly Single submitter ⚠
- p.Arg43Gly Single submitter ⚠
- p.Arg43Pro Single submitter ⚠
- p.Arg49Ser Single submitter ⚠
- p.Arg5Lys Single submitter ⚠
- p.Asp214Gly Single submitter ⚠
- p.Asp235Val Single submitter ⚠
- p.Cys137Ser Single submitter ⚠
- p.Gln151His Single submitter ⚠
- p.Gln21Arg Single submitter ⚠
- p.Gln225His Single submitter ⚠
- p.Glu10Lys Single submitter ⚠
- p.Glu122Gly Single submitter ⚠
- p.Glu207Lys Single submitter ⚠
- p.Glu218Lys Single submitter ⚠
- p.Gly13Val Single submitter ⚠
- p.Gly148Glu Single submitter ⚠
- p.Gly211Arg Single submitter ⚠
- p.Gly22Arg Single submitter ⚠
- p.Gly33Val Single submitter ⚠
- p.Gly59Arg Single submitter ⚠
- p.Gly59Cys Single submitter ⚠
- p.Gly59Ser Single submitter ⚠
- p.Gly66Ala Single submitter ⚠
- p.Gly73Val Single submitter ⚠
- p.His32Leu Single submitter ⚠
- p.Leu117Met Single submitter ⚠
- p.Leu216Phe Single submitter ⚠
- p.Leu23Val Single submitter ⚠
- p.Leu24Met Single submitter ⚠
- p.Leu25Pro Single submitter ⚠
- p.Leu45Pro Single submitter ⚠
- p.Leu53Val Single submitter ⚠
- p.Lys229Asn Single submitter ⚠
- p.Phe20Leu Single submitter ⚠
- p.Phe247Leu Single submitter ⚠
- p.Phe248Val Single submitter ⚠
- p.Pro6Thr Single submitter ⚠
- p.Ser191Arg Single submitter ⚠
- p.Ser205Asn Single submitter ⚠
- p.Ser61Leu Single submitter ⚠
- p.Ser61Pro Single submitter ⚠
- p.Ser63Arg Single submitter ⚠
- p.Thr126Ala Single submitter ⚠
- p.Thr65Lys Single submitter ⚠
- p.Val72Met Single submitter ⚠