APOOL — 36 ClinVar variants
All ClinVar germline APOOL variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
5 Likely benign · 31 Uncertain significance
Full APOOL gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- APOOL p.Ala124Glu Uncertain significance Single submitter
- APOOL p.Ala178Gly Uncertain significance Single submitter
- APOOL p.Ala241Ser Uncertain significance Single submitter
- APOOL p.Gln173His Uncertain significance Single submitter
- APOOL p.Gly15Ala Uncertain significance Single submitter
- APOOL p.Gly202Glu Uncertain significance Single submitter
- APOOL p.Gly240Val Uncertain significance Single submitter
- APOOL p.His215Gln Uncertain significance Single submitter
- APOOL p.Ile175Met Uncertain significance Single submitter
- APOOL p.Ile261Thr Uncertain significance Single submitter
- APOOL p.Lys185Glu Uncertain significance Single submitter
- APOOL p.Met12Val Uncertain significance Single submitter
- APOOL p.Met63Thr Uncertain significance Single submitter
- APOOL p.Ser228Gly Uncertain significance Single submitter
- APOOL p.Thr242Ala Uncertain significance Single submitter
- APOOL p.Thr93Lys Uncertain significance Single submitter
- APOOL p.Val216Ile Uncertain significance Single submitter
- APOOL p.Val21Ala Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- APOOL p.Arg69Cys Uncertain significance Single submitter
- APOOL p.Arg69His Uncertain significance Single submitter
- APOOL p.Gln156His Uncertain significance Single submitter
- APOOL p.Glu30Lys Uncertain significance Single submitter
- APOOL p.Gly59Cys Uncertain significance Single submitter
- APOOL p.Ile43Met Uncertain significance Single submitter
- APOOL p.Leu147Ser Uncertain significance Single submitter
- APOOL p.Phe244Leu Uncertain significance Single submitter
- APOOL p.Phe65Leu Uncertain significance Single submitter
- APOOL p.Pro113Leu Uncertain significance Single submitter
- APOOL p.Pro195Arg Likely benign Single submitter
- APOOL p.Ser121Leu Uncertain significance Single submitter
- APOOL p.Ser237Tyr Uncertain significance Single submitter
- APOOL p.Ser265Asn Uncertain significance Single submitter
All APOOL variants
Likely benign 5
- p.Arg109Gln Single submitter
- p.Pro195Arg Single submitter ⚠
- p.Thr139Ala Single submitter
- p.Val158Ile Single submitter
- p.Val168Ile Single submitter
Uncertain significance 31
- p.Ala124Glu Single submitter ⚠
- p.Ala178Gly Single submitter ⚠
- p.Ala241Ser Single submitter ⚠
- p.Arg69Cys Single submitter ⚠
- p.Arg69His Single submitter ⚠
- p.Gln156His Single submitter ⚠
- p.Gln173His Single submitter ⚠
- p.Glu30Lys Single submitter ⚠
- p.Gly15Ala Single submitter ⚠
- p.Gly202Glu Single submitter ⚠
- p.Gly240Val Single submitter ⚠
- p.Gly59Cys Single submitter ⚠
- p.His215Gln Single submitter ⚠
- p.Ile175Met Single submitter ⚠
- p.Ile261Thr Single submitter ⚠
- p.Ile43Met Single submitter ⚠
- p.Leu147Ser Single submitter ⚠
- p.Lys185Glu Single submitter ⚠
- p.Met12Val Single submitter ⚠
- p.Met63Thr Single submitter ⚠
- p.Phe244Leu Single submitter ⚠
- p.Phe65Leu Single submitter ⚠
- p.Pro113Leu Single submitter ⚠
- p.Ser121Leu Single submitter ⚠
- p.Ser228Gly Single submitter ⚠
- p.Ser237Tyr Single submitter ⚠
- p.Ser265Asn Single submitter ⚠
- p.Thr242Ala Single submitter ⚠
- p.Thr93Lys Single submitter ⚠
- p.Val216Ile Single submitter ⚠
- p.Val21Ala Single submitter ⚠