AQP10 — 28 ClinVar variants
All ClinVar germline AQP10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 26 flagged for review →
1 Benign · 1 Likely benign · 26 Uncertain significance
Full AQP10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 26
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- AQP10 p.Ala292Val Uncertain significance Single submitter
- AQP10 p.Ala41Pro Uncertain significance Single submitter
- AQP10 p.Arg222Cys Uncertain significance Single submitter
- AQP10 p.Asn214Lys Uncertain significance Single submitter
- AQP10 p.Glu273Lys Uncertain significance Single submitter
- AQP10 p.Gly210Arg Uncertain significance Single submitter
- AQP10 p.Ile145Thr Uncertain significance Single submitter
- AQP10 p.Ile171Thr Uncertain significance Single submitter
- AQP10 p.Leu95Arg Uncertain significance Single submitter
- AQP10 p.Lys300Gln Uncertain significance Single submitter
- AQP10 p.Met296Thr Uncertain significance Single submitter
- AQP10 p.Pro150Ser Uncertain significance Single submitter
- AQP10 p.Pro221Ser Uncertain significance Single submitter
- AQP10 p.Ser48Arg Uncertain significance Single submitter
- AQP10 p.Val92Ile Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- AQP10 p.Ala216Val Uncertain significance Single submitter
- AQP10 p.Ala228Thr Uncertain significance Single submitter
- AQP10 p.Ala88Val Uncertain significance Single submitter
- AQP10 p.Arg17His Uncertain significance Single submitter
- AQP10 p.Arg181Gln Uncertain significance Single submitter
- AQP10 p.Arg22Gln Uncertain significance Single submitter
- AQP10 p.Arg94Cys Uncertain significance Single submitter
- AQP10 p.Gly73Asp Uncertain significance Single submitter
- AQP10 p.Leu219Val Uncertain significance Single submitter
- AQP10 p.Thr47Ala Uncertain significance Single submitter
- AQP10 p.Tyr129Asn Uncertain significance Single submitter
All AQP10 variants
Benign 1
- c.105+10A>G Multiple submitters
Likely benign 1
- p.Pro7Leu Single submitter
Uncertain significance 26
- p.Ala216Val Single submitter ⚠
- p.Ala228Thr Single submitter ⚠
- p.Ala292Val Single submitter ⚠
- p.Ala41Pro Single submitter ⚠
- p.Ala88Val Single submitter ⚠
- p.Arg17His Single submitter ⚠
- p.Arg181Gln Single submitter ⚠
- p.Arg222Cys Single submitter ⚠
- p.Arg22Gln Single submitter ⚠
- p.Arg94Cys Single submitter ⚠
- p.Asn214Lys Single submitter ⚠
- p.Glu273Lys Single submitter ⚠
- p.Gly210Arg Single submitter ⚠
- p.Gly73Asp Single submitter ⚠
- p.Ile145Thr Single submitter ⚠
- p.Ile171Thr Single submitter ⚠
- p.Leu219Val Single submitter ⚠
- p.Leu95Arg Single submitter ⚠
- p.Lys300Gln Single submitter ⚠
- p.Met296Thr Single submitter ⚠
- p.Pro150Ser Single submitter ⚠
- p.Pro221Ser Single submitter ⚠
- p.Ser48Arg Single submitter ⚠
- p.Thr47Ala Single submitter ⚠
- p.Tyr129Asn Single submitter ⚠
- p.Val92Ile Single submitter ⚠