AQR — 136 ClinVar variants
All ClinVar germline AQR variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 128 flagged for review →
4 Likely benign · 132 Uncertain significance
Full AQR gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 128
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 91
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- AQR p.Ala129Val Uncertain significance Single submitter
- AQR p.Ala1415Gly Uncertain significance Single submitter
- AQR p.Ala1432Gly Uncertain significance Single submitter
- AQR p.Ala1464Thr Uncertain significance Single submitter
- AQR p.Ala211Thr Uncertain significance Single submitter
- AQR p.Ala352Ser Uncertain significance Single submitter
- AQR p.Arg1125His Uncertain significance Single submitter
- AQR p.Arg1288His Uncertain significance Single submitter
- AQR p.Arg1427Cys Uncertain significance Single submitter
- AQR p.Arg1427His Uncertain significance Single submitter
- AQR p.Arg163Pro Uncertain significance Single submitter
- AQR p.Arg482His Uncertain significance Single submitter
- AQR p.Arg579Gln Uncertain significance Single submitter
- AQR p.Arg606His Uncertain significance Single submitter
- AQR p.Arg904Gln Uncertain significance Single submitter
- AQR p.Asn1344Ile Uncertain significance Single submitter
- AQR p.Asn1472His Uncertain significance Single submitter
- AQR p.Asn19Ser Uncertain significance Single submitter
- AQR p.Asn707Ser Uncertain significance Single submitter
- AQR p.Asp1423Glu Uncertain significance Single submitter
- AQR p.Asp1476His Uncertain significance Single submitter
- AQR p.Asp763Val Uncertain significance Single submitter
- AQR p.Asp768Asn Uncertain significance Single submitter
- AQR p.Gln1414Glu Uncertain significance Single submitter
- AQR p.Gln227Arg Uncertain significance Single submitter
- AQR p.Gln633Glu Uncertain significance Single submitter
- AQR p.Glu1408Lys Uncertain significance Single submitter
- AQR p.Glu1429Asp Uncertain significance Single submitter
- AQR p.Glu1441Lys Uncertain significance Single submitter
- AQR p.Glu772Lys Uncertain significance Single submitter
- AQR p.Glu773Lys Uncertain significance Single submitter
- AQR p.Glu963Asp Uncertain significance Single submitter
- AQR p.Gly1172Ala Uncertain significance Single submitter
- AQR p.Gly501Ser Uncertain significance Single submitter
- AQR p.Gly828Val Uncertain significance Single submitter
- AQR p.His1159Tyr Uncertain significance Single submitter
- AQR p.His1371Tyr Uncertain significance Single submitter
- AQR p.His344Tyr Uncertain significance Single submitter
- AQR p.His723Tyr Uncertain significance Single submitter
- AQR p.Ile418Val Uncertain significance Single submitter
- AQR p.Ile49Thr Uncertain significance Single submitter
- AQR p.Ile527Leu Uncertain significance Single submitter
- AQR p.Ile527Val Uncertain significance Single submitter
- AQR p.Ile64Met Uncertain significance Single submitter
- AQR p.Ile749Lys Uncertain significance Single submitter
- AQR p.Ile800Val Uncertain significance Single submitter
- AQR p.Ile871Val Uncertain significance Single submitter
- AQR p.Ile94Val Uncertain significance Single submitter
- AQR p.Ile981Thr Uncertain significance Single submitter
- AQR p.Leu1133Ile Uncertain significance Single submitter
- AQR p.Leu1216Ile Uncertain significance Single submitter
- AQR p.Leu180Met Uncertain significance Single submitter
- AQR p.Leu256Phe Uncertain significance Single submitter
- AQR p.Lys189Arg Uncertain significance Single submitter
- AQR p.Lys37Asn Uncertain significance Single submitter
- AQR p.Lys550Arg Uncertain significance Single submitter
- AQR p.Met991Val Uncertain significance Single submitter
- AQR p.Phe936Tyr Uncertain significance Single submitter
- AQR p.Phe967Leu Uncertain significance Single submitter
- AQR p.Pro1249Ala Uncertain significance Single submitter
- AQR p.Pro1388Ala Uncertain significance Single submitter
- AQR p.Pro1431Leu Uncertain significance Single submitter
- AQR p.Pro1431Thr Uncertain significance Single submitter
- AQR p.Pro1439Arg Uncertain significance Single submitter
- AQR p.Pro1448Leu Uncertain significance Single submitter
- AQR p.Pro1481Leu Uncertain significance Single submitter
- AQR p.Pro191Arg Uncertain significance Single submitter
- AQR p.Pro241Ser Uncertain significance Single submitter
- AQR p.Pro453Arg Uncertain significance Single submitter
- AQR p.Pro4Ser Uncertain significance Single submitter
- AQR p.Ser1024Ala Uncertain significance Single submitter
- AQR p.Ser488Arg Uncertain significance Single submitter
- AQR p.Thr1335Ile Uncertain significance Single submitter
- AQR p.Thr1340Ala Uncertain significance Single submitter
- AQR p.Thr1376Ala Uncertain significance Single submitter
- AQR p.Thr1430Ile Uncertain significance Single submitter
- AQR p.Thr376Ile Uncertain significance Single submitter
- AQR p.Thr397Pro Uncertain significance Single submitter
- AQR p.Thr575Pro Uncertain significance Single submitter
- AQR p.Thr575Ser Uncertain significance Single submitter
- AQR p.Thr750Ile Uncertain significance Single submitter
- AQR p.Thr966Ile Uncertain significance Single submitter
- AQR p.Tyr1198Cys Uncertain significance Single submitter
- AQR p.Tyr1198Phe Uncertain significance Single submitter
- AQR p.Tyr1379Cys Uncertain significance Single submitter
- AQR p.Tyr349Cys Uncertain significance Single submitter
- AQR p.Tyr349His Uncertain significance Single submitter
- AQR p.Val11Leu Uncertain significance Single submitter
- AQR p.Val520Ile Uncertain significance Single submitter
- AQR p.Val821Leu Uncertain significance Single submitter
- AQR p.Val961Ile Uncertain significance Single submitter
Predictors split 37
The independent predictors disagree with each other — read with care.
- AQR p.Ala89Thr Uncertain significance Single submitter
- AQR p.Arg413Cys Uncertain significance Single submitter
- AQR p.Arg414Gly Uncertain significance Single submitter
- AQR p.Arg474His Uncertain significance Single submitter
- AQR p.Arg580Trp Uncertain significance Single submitter
- AQR p.Arg606Cys Uncertain significance Single submitter
- AQR p.Arg914Gln Uncertain significance Single submitter
- AQR p.Cys385Tyr Uncertain significance Single submitter
- AQR p.Cys681Phe Uncertain significance Single submitter
- AQR p.Glu261Gln Uncertain significance Single submitter
- AQR p.Gly1187Arg Uncertain significance Single submitter
- AQR p.Gly1189Ala Uncertain significance Single submitter
- AQR p.Gly295Ser Uncertain significance Single submitter
- AQR p.Ile1332Thr Uncertain significance Single submitter
- AQR p.Ile527Met Uncertain significance Single submitter
- AQR p.Leu1133Phe Uncertain significance Single submitter
- AQR p.Leu629Met Uncertain significance Single submitter
- AQR p.Lys195Thr Uncertain significance Single submitter
- AQR p.Lys9Asn Uncertain significance Single submitter
- AQR p.Met1368Ile Uncertain significance Single submitter
- AQR p.Met820Val Uncertain significance Single submitter
- AQR p.Phe122Ile Uncertain significance Single submitter
- AQR p.Phe122Leu Uncertain significance Single submitter
- AQR p.Phe1310Leu Uncertain significance Single submitter
- AQR p.Pro1220Ser Uncertain significance Single submitter
- AQR p.Pro1249Gln Uncertain significance Single submitter
- AQR p.Pro1249Thr Uncertain significance Single submitter
- AQR p.Pro616Ser Uncertain significance Single submitter
- AQR p.Ser364Phe Uncertain significance Single submitter
- AQR p.Ser445Pro Uncertain significance Single submitter
- AQR p.Thr144Ala Uncertain significance Single submitter
- AQR p.Thr272Ser Uncertain significance Single submitter
- AQR p.Thr776Ala Uncertain significance Single submitter
- AQR p.Tyr444Cys Uncertain significance Single submitter
- AQR p.Val682Leu Uncertain significance Single submitter
-
AQR p.Asn1248Thr
Likely benign
No assertion criteria
EBV-positive nodal T- and NK-cell lymphoma
-
AQR p.Gln165His
Uncertain significance
No assertion criteria
AQR-related condition
All AQR variants
Likely benign 4
- p.Glu1482Ala Single submitter
- p.Gly1394Ser Single submitter
- p.Thr1412Pro Single submitter
- p.Asn1248Thr No assertion criteria EBV-positive nodal T- and NK-cell lymphoma ⚠
Uncertain significance 132
- p.Ala129Val Single submitter ⚠
- p.Ala1415Gly Single submitter ⚠
- p.Ala1432Gly Single submitter ⚠
- p.Ala1464Thr Single submitter ⚠
- p.Ala211Thr Single submitter ⚠
- p.Ala352Ser Single submitter ⚠
- p.Ala89Thr Single submitter ⚠
- p.Arg1125His Single submitter ⚠
- p.Arg1244Ter Single submitter
- p.Arg1288His Single submitter ⚠
- p.Arg1427Cys Single submitter ⚠
- p.Arg1427His Single submitter ⚠
- p.Arg163Pro Single submitter ⚠
- p.Arg413Cys Single submitter ⚠
- p.Arg414Gly Single submitter ⚠
- p.Arg474His Single submitter ⚠
- p.Arg482His Single submitter ⚠
- p.Arg579Gln Single submitter ⚠
- p.Arg579Leu Single submitter
- p.Arg580Trp Single submitter ⚠
- p.Arg606Cys Single submitter ⚠
- p.Arg606His Single submitter ⚠
- p.Arg797Cys Single submitter
- p.Arg904Gln Single submitter ⚠
- p.Arg914Gln Single submitter ⚠
- p.Asn1148Lys Single submitter
- p.Asn1344Ile Single submitter ⚠
- p.Asn1472His Single submitter ⚠
- p.Asn19Ser Single submitter ⚠
- p.Asn707Ser Single submitter ⚠
- p.Asp1423Glu Single submitter ⚠
- p.Asp1476His Single submitter ⚠
- p.Asp763Val Single submitter ⚠
- p.Asp768Asn Single submitter ⚠
- p.Cys385Tyr Single submitter ⚠
- p.Cys681Phe Single submitter ⚠
- p.Gln1414Glu Single submitter ⚠
- p.Gln227Arg Single submitter ⚠
- p.Gln633Glu Single submitter ⚠
- p.Glu1408Lys Single submitter ⚠
- p.Glu1429Asp Single submitter ⚠
- p.Glu1441Lys Single submitter ⚠
- p.Glu261Gln Single submitter ⚠
- p.Glu772Lys Single submitter ⚠
- p.Glu773Lys Single submitter ⚠
- p.Glu963Asp Single submitter ⚠
- p.Gly1172Ala Single submitter ⚠
- p.Gly1187Arg Single submitter ⚠
- p.Gly1189Ala Single submitter ⚠
- p.Gly295Ser Single submitter ⚠
- p.Gly501Ser Single submitter ⚠
- p.Gly828Val Single submitter ⚠
- p.His1159Tyr Single submitter ⚠
- p.His1371Tyr Single submitter ⚠
- p.His344Tyr Single submitter ⚠
- p.His723Tyr Single submitter ⚠
- p.Ile1332Thr Single submitter ⚠
- p.Ile418Val Single submitter ⚠
- p.Ile49Thr Single submitter ⚠
- p.Ile527Leu Single submitter ⚠
- p.Ile527Met Single submitter ⚠
- p.Ile527Val Single submitter ⚠
- p.Ile64Met Single submitter ⚠
- p.Ile749Lys Single submitter ⚠
- p.Ile800Val Single submitter ⚠
- p.Ile871Val Single submitter ⚠
- p.Ile94Val Single submitter ⚠
- p.Ile981Thr Single submitter ⚠
- p.Leu1133Ile Single submitter ⚠
- p.Leu1133Phe Single submitter ⚠
- p.Leu1216Ile Single submitter ⚠
- p.Leu148Phe Single submitter
- p.Leu180Met Single submitter ⚠
- p.Leu256Phe Single submitter ⚠
- p.Leu629Met Single submitter ⚠
- p.Lys189Arg Single submitter ⚠
- p.Lys195Thr Single submitter ⚠
- p.Lys37Asn Single submitter ⚠
- p.Lys550Arg Single submitter ⚠
- p.Lys9Asn Single submitter ⚠
- p.Met1368Ile Single submitter ⚠
- p.Met820Val Single submitter ⚠
- p.Met991Val Single submitter ⚠
- p.Phe122Ile Single submitter ⚠
- p.Phe122Leu Single submitter ⚠
- p.Phe1310Leu Single submitter ⚠
- p.Phe936Tyr Single submitter ⚠
- p.Phe967Leu Single submitter ⚠
- p.Pro1220Ser Single submitter ⚠
- p.Pro1249Ala Single submitter ⚠
- p.Pro1249Gln Single submitter ⚠
- p.Pro1249Thr Single submitter ⚠
- p.Pro1388Ala Single submitter ⚠
- p.Pro1431Leu Single submitter ⚠
- p.Pro1431Thr Single submitter ⚠
- p.Pro1439Arg Single submitter ⚠
- p.Pro1448Leu Single submitter ⚠
- p.Pro1481Leu Single submitter ⚠
- p.Pro191Arg Single submitter ⚠
- p.Pro241Ser Single submitter ⚠
- p.Pro453Arg Single submitter ⚠
- p.Pro4Ser Single submitter ⚠
- p.Pro616Ser Single submitter ⚠
- p.Ser1024Ala Single submitter ⚠
- p.Ser364Phe Single submitter ⚠
- p.Ser445Pro Single submitter ⚠
- p.Ser488Arg Single submitter ⚠
- p.Thr1335Ile Single submitter ⚠
- p.Thr1340Ala Single submitter ⚠
- p.Thr1376Ala Single submitter ⚠
- p.Thr1430Ile Single submitter ⚠
- p.Thr144Ala Single submitter ⚠
- p.Thr272Ser Single submitter ⚠
- p.Thr376Ile Single submitter ⚠
- p.Thr397Pro Single submitter ⚠
- p.Thr575Pro Single submitter ⚠
- p.Thr575Ser Single submitter ⚠
- p.Thr750Ile Single submitter ⚠
- p.Thr776Ala Single submitter ⚠
- p.Thr966Ile Single submitter ⚠
- p.Tyr1198Cys Single submitter ⚠
- p.Tyr1198Phe Single submitter ⚠
- p.Tyr1379Cys Single submitter ⚠
- p.Tyr349Cys Single submitter ⚠
- p.Tyr349His Single submitter ⚠
- p.Tyr444Cys Single submitter ⚠
- p.Val11Leu Single submitter ⚠
- p.Val520Ile Single submitter ⚠
- p.Val682Leu Single submitter ⚠
- p.Val821Leu Single submitter ⚠
- p.Val961Ile Single submitter ⚠
- p.Gln165His No assertion criteria AQR-related condition ⚠