ARB2A — 48 ClinVar variants
All ClinVar germline ARB2A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 48 flagged for review →
48 Uncertain significance
Full ARB2A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 48
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARB2A p.Ala283Val Uncertain significance Single submitter
- ARB2A p.Arg240Gln Uncertain significance Single submitter
- ARB2A p.Arg306Gln Uncertain significance Single submitter
- ARB2A p.Asn68Lys Uncertain significance Single submitter
- ARB2A p.Asp142Glu Uncertain significance Single submitter
- ARB2A p.Asp26Glu Uncertain significance Single submitter
- ARB2A p.Gln19Arg Uncertain significance Single submitter
- ARB2A p.Gln258His Uncertain significance Single submitter
- ARB2A p.Glu132Lys Uncertain significance Single submitter
- ARB2A p.Glu228Asp Uncertain significance Single submitter
- ARB2A p.Glu228Lys Uncertain significance Single submitter
- ARB2A p.Glu99Lys Uncertain significance Single submitter
- ARB2A p.Ile105Thr Uncertain significance Single submitter
- ARB2A p.Ile13Val Uncertain significance Single submitter
- ARB2A p.Ile279Val Uncertain significance Single submitter
- ARB2A p.Ile3Val Uncertain significance Single submitter
- ARB2A p.Leu101Pro Uncertain significance Single submitter
- ARB2A p.Phe56Ile Uncertain significance Single submitter
- ARB2A p.Ser266Phe Uncertain significance Single submitter
- ARB2A p.Ser322Cys Uncertain significance Single submitter
- ARB2A p.Thr32Ala Uncertain significance Single submitter
- ARB2A p.Thr59Ile Uncertain significance Single submitter
- ARB2A p.Val109Ala Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- ARB2A p.Ala271Val Uncertain significance Single submitter
- ARB2A p.Arg227Gly Uncertain significance Single submitter
- ARB2A p.Arg227Trp Uncertain significance Single submitter
- ARB2A p.Arg241Cys Uncertain significance Single submitter
- ARB2A p.Arg241His Uncertain significance Single submitter
- ARB2A p.Asn146Asp Uncertain significance Single submitter
- ARB2A p.Asn200Ser Uncertain significance Single submitter
- ARB2A p.Asp116Gly Uncertain significance Single submitter
- ARB2A p.Asp116Tyr Uncertain significance Single submitter
- ARB2A p.Glu111Lys Uncertain significance Single submitter
- ARB2A p.Glu114Gly Uncertain significance Single submitter
- ARB2A p.Glu414Gln Uncertain significance Single submitter
- ARB2A p.Ile137Met Uncertain significance Single submitter
- ARB2A p.Ile195Met Uncertain significance Single submitter
- ARB2A p.Leu112Ile Uncertain significance Single submitter
- ARB2A p.Lys226Glu Uncertain significance Single submitter
- ARB2A p.Lys387Gln Uncertain significance Single submitter
- ARB2A p.Pro209Leu Uncertain significance Single submitter
- ARB2A p.Pro209Ser Uncertain significance Single submitter
- ARB2A p.Ser135Asn Uncertain significance Single submitter
- ARB2A p.Ser359Ala Uncertain significance Single submitter
- ARB2A p.Thr334Met Uncertain significance Single submitter
- ARB2A p.Tyr192Cys Uncertain significance Single submitter
- ARB2A p.Val290Ile Uncertain significance Single submitter
- ARB2A p.Val326Leu Uncertain significance Single submitter
All ARB2A variants
Uncertain significance 48
- p.Ala271Val Single submitter ⚠
- p.Ala283Val Single submitter ⚠
- p.Arg227Gly Single submitter ⚠
- p.Arg227Trp Single submitter ⚠
- p.Arg240Gln Single submitter ⚠
- p.Arg241Cys Single submitter ⚠
- p.Arg241His Single submitter ⚠
- p.Arg306Gln Single submitter ⚠
- p.Asn146Asp Single submitter ⚠
- p.Asn200Ser Single submitter ⚠
- p.Asn68Lys Single submitter ⚠
- p.Asp116Gly Single submitter ⚠
- p.Asp116Tyr Single submitter ⚠
- p.Asp142Glu Single submitter ⚠
- p.Asp26Glu Single submitter ⚠
- p.Gln19Arg Single submitter ⚠
- p.Gln258His Single submitter ⚠
- p.Glu111Lys Single submitter ⚠
- p.Glu114Gly Single submitter ⚠
- p.Glu132Lys Single submitter ⚠
- p.Glu228Asp Single submitter ⚠
- p.Glu228Lys Single submitter ⚠
- p.Glu414Gln Single submitter ⚠
- p.Glu99Lys Single submitter ⚠
- p.Ile105Thr Single submitter ⚠
- p.Ile137Met Single submitter ⚠
- p.Ile13Val Single submitter ⚠
- p.Ile195Met Single submitter ⚠
- p.Ile279Val Single submitter ⚠
- p.Ile3Val Single submitter ⚠
- p.Leu101Pro Single submitter ⚠
- p.Leu112Ile Single submitter ⚠
- p.Lys226Glu Single submitter ⚠
- p.Lys387Gln Single submitter ⚠
- p.Phe56Ile Single submitter ⚠
- p.Pro209Leu Single submitter ⚠
- p.Pro209Ser Single submitter ⚠
- p.Ser135Asn Single submitter ⚠
- p.Ser266Phe Single submitter ⚠
- p.Ser322Cys Single submitter ⚠
- p.Ser359Ala Single submitter ⚠
- p.Thr32Ala Single submitter ⚠
- p.Thr334Met Single submitter ⚠
- p.Thr59Ile Single submitter ⚠
- p.Tyr192Cys Single submitter ⚠
- p.Val109Ala Single submitter ⚠
- p.Val290Ile Single submitter ⚠
- p.Val326Leu Single submitter ⚠