ARFIP1 — 44 ClinVar variants
All ClinVar germline ARFIP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 43 flagged for review →
1 Likely benign · 43 Uncertain significance
Full ARFIP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 43
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARFIP1 p.Ala114Thr Uncertain significance Single submitter
- ARFIP1 p.Ala234Thr Uncertain significance Single submitter
- ARFIP1 p.Ala339Ser Uncertain significance Single submitter
- ARFIP1 p.Asn18Ser Uncertain significance Single submitter
- ARFIP1 p.Asn344Ser Uncertain significance Single submitter
- ARFIP1 p.Asp198Ala Uncertain significance Single submitter
- ARFIP1 p.Asp310Glu Uncertain significance Single submitter
- ARFIP1 p.Asp54Gly Uncertain significance Single submitter
- ARFIP1 p.Gln350His Uncertain significance Single submitter
- ARFIP1 p.Gly150Ala Uncertain significance Single submitter
- ARFIP1 p.Gly40Glu Uncertain significance Single submitter
- ARFIP1 p.His27Arg Uncertain significance Single submitter
- ARFIP1 p.His334Arg Uncertain significance Single submitter
- ARFIP1 p.Ile164Thr Uncertain significance Single submitter
- ARFIP1 p.Ile337Met Uncertain significance Single submitter
- ARFIP1 p.Ile61Thr Uncertain significance Single submitter
- ARFIP1 p.Leu245Ser Uncertain significance Single submitter
- ARFIP1 p.Met122Val Uncertain significance Single submitter
- ARFIP1 p.Phe341Ser Uncertain significance Single submitter
- ARFIP1 p.Pro72Leu Uncertain significance Single submitter
- ARFIP1 p.Ser108Gly Uncertain significance Single submitter
- ARFIP1 p.Ser17Gly Uncertain significance Single submitter
- ARFIP1 p.Thr253Ile Uncertain significance Single submitter
- ARFIP1 p.Trp369Cys Uncertain significance Single submitter
Predictors split 19
The independent predictors disagree with each other — read with care.
- ARFIP1 p.Ala284Thr Uncertain significance Single submitter
- ARFIP1 p.Arg149His Uncertain significance Single submitter
- ARFIP1 p.Gln180Glu Uncertain significance Single submitter
- ARFIP1 p.Gln354Arg Uncertain significance Single submitter
- ARFIP1 p.Glu251Gly Uncertain significance Single submitter
- ARFIP1 p.His356Arg Uncertain significance Single submitter
- ARFIP1 p.Ile235Val Uncertain significance Single submitter
- ARFIP1 p.Ile265Thr Uncertain significance Single submitter
- ARFIP1 p.Leu176Phe Uncertain significance Single submitter
- ARFIP1 p.Leu287Val Uncertain significance Single submitter
- ARFIP1 p.Leu296Ile Uncertain significance Single submitter
- ARFIP1 p.Leu33Trp Uncertain significance Single submitter
- ARFIP1 p.Leu43Phe Uncertain significance Single submitter
- ARFIP1 p.Met122Thr Uncertain significance Single submitter
- ARFIP1 p.Pro362Ser Uncertain significance Single submitter
- ARFIP1 p.Pro367Thr Uncertain significance Single submitter
- ARFIP1 p.Ser241Gly Uncertain significance Single submitter
- ARFIP1 p.Thr286Ser Uncertain significance Single submitter
- ARFIP1 p.Val190Ala Uncertain significance Single submitter
All ARFIP1 variants
Likely benign 1
- p.Arg25His Single submitter
Uncertain significance 43
- p.Ala114Thr Single submitter ⚠
- p.Ala234Thr Single submitter ⚠
- p.Ala284Thr Single submitter ⚠
- p.Ala339Ser Single submitter ⚠
- p.Arg149His Single submitter ⚠
- p.Asn18Ser Single submitter ⚠
- p.Asn344Ser Single submitter ⚠
- p.Asp198Ala Single submitter ⚠
- p.Asp310Glu Single submitter ⚠
- p.Asp54Gly Single submitter ⚠
- p.Gln180Glu Single submitter ⚠
- p.Gln350His Single submitter ⚠
- p.Gln354Arg Single submitter ⚠
- p.Glu251Gly Single submitter ⚠
- p.Gly150Ala Single submitter ⚠
- p.Gly40Glu Single submitter ⚠
- p.His27Arg Single submitter ⚠
- p.His334Arg Single submitter ⚠
- p.His356Arg Single submitter ⚠
- p.Ile164Thr Single submitter ⚠
- p.Ile235Val Single submitter ⚠
- p.Ile265Thr Single submitter ⚠
- p.Ile337Met Single submitter ⚠
- p.Ile61Thr Single submitter ⚠
- p.Leu176Phe Single submitter ⚠
- p.Leu245Ser Single submitter ⚠
- p.Leu287Val Single submitter ⚠
- p.Leu296Ile Single submitter ⚠
- p.Leu33Trp Single submitter ⚠
- p.Leu43Phe Single submitter ⚠
- p.Met122Thr Single submitter ⚠
- p.Met122Val Single submitter ⚠
- p.Phe341Ser Single submitter ⚠
- p.Pro362Ser Single submitter ⚠
- p.Pro367Thr Single submitter ⚠
- p.Pro72Leu Single submitter ⚠
- p.Ser108Gly Single submitter ⚠
- p.Ser17Gly Single submitter ⚠
- p.Ser241Gly Single submitter ⚠
- p.Thr253Ile Single submitter ⚠
- p.Thr286Ser Single submitter ⚠
- p.Trp369Cys Single submitter ⚠
- p.Val190Ala Single submitter ⚠