ARFIP2 — 35 ClinVar variants
All ClinVar germline ARFIP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
2 Likely benign · 33 Uncertain significance
Full ARFIP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARFIP2 p.Arg269Trp Uncertain significance Single submitter
- ARFIP2 p.Arg276Gln Uncertain significance Single submitter
- ARFIP2 p.Arg328Gln Uncertain significance Single submitter
- ARFIP2 p.Glu229Asp Uncertain significance Single submitter
- ARFIP2 p.Gly4Arg Uncertain significance Single submitter
- ARFIP2 p.Gly56Trp Uncertain significance Single submitter
- ARFIP2 p.Gly57Ala Uncertain significance Single submitter
- ARFIP2 p.His302Arg Uncertain significance Single submitter
- ARFIP2 p.His70Tyr Uncertain significance Single submitter
- ARFIP2 p.His73Gln Uncertain significance Single submitter
- ARFIP2 p.Ile63Thr Uncertain significance Single submitter
- ARFIP2 p.Leu233Val Uncertain significance Single submitter
- ARFIP2 p.Lys292Asn Uncertain significance Single submitter
- ARFIP2 p.Phe205Leu Uncertain significance Single submitter
- ARFIP2 p.Pro26Ser Uncertain significance Single submitter
- ARFIP2 p.Pro64Ala Uncertain significance Single submitter
- ARFIP2 p.Ser260Asn Uncertain significance Single submitter
- ARFIP2 p.Ser306Phe Uncertain significance Single submitter
- ARFIP2 p.Val122Met Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- ARFIP2 p.Ala252Ser Uncertain significance Single submitter
- ARFIP2 p.Arg138His Uncertain significance Single submitter
- ARFIP2 p.Arg148Gln Uncertain significance Single submitter
- ARFIP2 p.Arg86Gly Uncertain significance Single submitter
- ARFIP2 p.Gln266Arg Uncertain significance Single submitter
- ARFIP2 p.Gly256Asp Uncertain significance Single submitter
- ARFIP2 p.Ile325Leu Uncertain significance Single submitter
- ARFIP2 p.Leu258Phe Uncertain significance Single submitter
- ARFIP2 p.Ser52Pro Uncertain significance Single submitter
- ARFIP2 p.Val203Met Uncertain significance Single submitter
All ARFIP2 variants
Uncertain significance 33
- c.197-16G>A Single submitter
- c.197-75G>A Single submitter
- c.197-76A>G Single submitter
- c.197-87C>T Single submitter
- p.Ala252Ser Single submitter ⚠
- p.Arg138His Single submitter ⚠
- p.Arg148Gln Single submitter ⚠
- p.Arg269Trp Single submitter ⚠
- p.Arg276Gln Single submitter ⚠
- p.Arg328Gln Single submitter ⚠
- p.Arg86Gly Single submitter ⚠
- p.Gln266Arg Single submitter ⚠
- p.Glu229Asp Single submitter ⚠
- p.Gly256Asp Single submitter ⚠
- p.Gly4Arg Single submitter ⚠
- p.Gly56Trp Single submitter ⚠
- p.Gly57Ala Single submitter ⚠
- p.His302Arg Single submitter ⚠
- p.His70Tyr Single submitter ⚠
- p.His73Gln Single submitter ⚠
- p.Ile325Leu Single submitter ⚠
- p.Ile63Thr Single submitter ⚠
- p.Leu233Val Single submitter ⚠
- p.Leu258Phe Single submitter ⚠
- p.Lys292Asn Single submitter ⚠
- p.Phe205Leu Single submitter ⚠
- p.Pro26Ser Single submitter ⚠
- p.Pro64Ala Single submitter ⚠
- p.Ser260Asn Single submitter ⚠
- p.Ser306Phe Single submitter ⚠
- p.Ser52Pro Single submitter ⚠
- p.Val122Met Single submitter ⚠
- p.Val203Met Single submitter ⚠