ARG2 — 52 ClinVar variants
All ClinVar germline ARG2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →
2 Benign · 1 Benign/Likely benign · 3 Likely benign · 46 Uncertain significance
Full ARG2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 47
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARG2 p.Ala106Pro Uncertain significance Single submitter
- ARG2 p.Ala123Thr Uncertain significance Single submitter
- ARG2 p.Ala191Ser Uncertain significance Single submitter
- ARG2 p.Ala31Asp Uncertain significance Single submitter
- ARG2 p.Arg105Ser Uncertain significance Single submitter
- ARG2 p.Arg132Gln Uncertain significance Single submitter
- ARG2 p.Arg351His Uncertain significance Single submitter
- ARG2 p.Asp147Ala Uncertain significance Single submitter
- ARG2 p.Asp70Gly Uncertain significance Single submitter
- ARG2 p.Gln243Lys Uncertain significance Single submitter
- ARG2 p.Gln325Arg Uncertain significance Single submitter
- ARG2 p.Glu345Lys Uncertain significance Single submitter
- ARG2 p.Gly117Arg Uncertain significance Single submitter
- ARG2 p.Gly226Cys Uncertain significance Single submitter
- ARG2 p.Gly269Arg Uncertain significance Single submitter
- ARG2 p.Gly330Arg Uncertain significance Single submitter
- ARG2 p.Gly5Val Uncertain significance Single submitter
- ARG2 p.His331Arg Uncertain significance Single submitter
- ARG2 p.Ile252Thr Uncertain significance Single submitter
- ARG2 p.Leu292Met Uncertain significance Single submitter
- ARG2 p.Pro32Leu Uncertain significance Single submitter
- ARG2 p.Pro75Leu Uncertain significance Single submitter
- ARG2 p.Thr13Ala Uncertain significance Single submitter
- ARG2 p.Thr150Lys Uncertain significance Single submitter
- ARG2 p.Thr154Pro Uncertain significance Single submitter
- ARG2 p.Tyr216Cys Uncertain significance Single submitter
- ARG2 p.Tyr216His Uncertain significance Single submitter
- ARG2 p.Val107Glu Uncertain significance Single submitter
- ARG2 p.Val175Ile Uncertain significance Single submitter
- ARG2 p.Val268Ala Uncertain significance Single submitter
- ARG2 p.Val352Leu Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- ARG2 p.Arg4Trp Likely benign Multiple submitters
- ARG2 p.Arg57Ser Uncertain significance Single submitter
- ARG2 p.Cys187Phe Uncertain significance Single submitter
- ARG2 p.Cys187Tyr Uncertain significance Single submitter
- ARG2 p.Glu170Gln Uncertain significance Single submitter
- ARG2 p.Ile319Thr Uncertain significance Single submitter
- ARG2 p.Leu225Val Uncertain significance Single submitter
- ARG2 p.Leu3Pro Uncertain significance Single submitter
- ARG2 p.Leu58Val Uncertain significance Single submitter
- ARG2 p.Phe181Leu Uncertain significance Single submitter
- ARG2 p.Pro163Thr Uncertain significance Single submitter
- ARG2 p.Pro340Ser Uncertain significance Single submitter
- ARG2 p.Ser2Tyr Uncertain significance Single submitter
- ARG2 p.Ser6Arg Uncertain significance Single submitter
- ARG2 p.Thr74Asn Uncertain significance Single submitter
- ARG2 p.Val102Met Uncertain significance Single submitter
All ARG2 variants
Benign 2
- p.Gly36= Multiple submitters
- c.860-11T>C Single submitter
Benign/Likely benign 1
- p.Ala308= Multiple submitters
Likely benign 3
- p.Arg4Trp Multiple submitters ⚠
- p.Arg233Gln Single submitter
- p.Pro176= Single submitter
Uncertain significance 46
- p.Ala106Pro Single submitter ⚠
- p.Ala123Thr Single submitter ⚠
- p.Ala191Ser Single submitter ⚠
- p.Ala31Asp Single submitter ⚠
- p.Arg105Ser Single submitter ⚠
- p.Arg132Gln Single submitter ⚠
- p.Arg351His Single submitter ⚠
- p.Arg57Ser Single submitter ⚠
- p.Asp147Ala Single submitter ⚠
- p.Asp70Gly Single submitter ⚠
- p.Cys187Phe Single submitter ⚠
- p.Cys187Tyr Single submitter ⚠
- p.Gln243Lys Single submitter ⚠
- p.Gln325Arg Single submitter ⚠
- p.Glu170Gln Single submitter ⚠
- p.Glu345Lys Single submitter ⚠
- p.Gly117Arg Single submitter ⚠
- p.Gly226Cys Single submitter ⚠
- p.Gly269Arg Single submitter ⚠
- p.Gly330Arg Single submitter ⚠
- p.Gly5Val Single submitter ⚠
- p.His331Arg Single submitter ⚠
- p.Ile252Thr Single submitter ⚠
- p.Ile319Thr Single submitter ⚠
- p.Leu225Val Single submitter ⚠
- p.Leu292Met Single submitter ⚠
- p.Leu3Pro Single submitter ⚠
- p.Leu58Val Single submitter ⚠
- p.Phe181Leu Single submitter ⚠
- p.Pro163Thr Single submitter ⚠
- p.Pro32Leu Single submitter ⚠
- p.Pro340Ser Single submitter ⚠
- p.Pro75Leu Single submitter ⚠
- p.Ser2Tyr Single submitter ⚠
- p.Ser6Arg Single submitter ⚠
- p.Thr13Ala Single submitter ⚠
- p.Thr150Lys Single submitter ⚠
- p.Thr154Pro Single submitter ⚠
- p.Thr74Asn Single submitter ⚠
- p.Tyr216Cys Single submitter ⚠
- p.Tyr216His Single submitter ⚠
- p.Val102Met Single submitter ⚠
- p.Val107Glu Single submitter ⚠
- p.Val175Ile Single submitter ⚠
- p.Val268Ala Single submitter ⚠
- p.Val352Leu Single submitter ⚠