ARHGAP12 — 101 ClinVar variants
All ClinVar germline ARHGAP12 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 98 flagged for review →
1 Benign · 4 Likely benign · 96 Uncertain significance
Full ARHGAP12 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 98
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 54
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARHGAP12 p.Ala393Val Uncertain significance Single submitter
- ARHGAP12 p.Ala458Ser Uncertain significance Single submitter
- ARHGAP12 p.Ala458Val Uncertain significance Single submitter
- ARHGAP12 p.Ala491Val Uncertain significance Single submitter
- ARHGAP12 p.Arg175His Uncertain significance Single submitter
- ARHGAP12 p.Arg548His Uncertain significance Single submitter
- ARHGAP12 p.Arg761Gln Uncertain significance Single submitter
- ARHGAP12 p.Asn133Ser Uncertain significance Single submitter
- ARHGAP12 p.Asn155Asp Uncertain significance Single submitter
- ARHGAP12 p.Asn311Thr Uncertain significance Single submitter
- ARHGAP12 p.Asn559Ser Uncertain significance Single submitter
- ARHGAP12 p.Asp431Asn Uncertain significance Single submitter
- ARHGAP12 p.Asp535Gly Uncertain significance Single submitter
- ARHGAP12 p.Asp722His Uncertain significance Single submitter
- ARHGAP12 p.Cys676Ser Uncertain significance Single submitter
- ARHGAP12 p.Gln124Arg Uncertain significance Single submitter
- ARHGAP12 p.Gln171Arg Uncertain significance Single submitter
- ARHGAP12 p.Gln197Arg Uncertain significance Single submitter
- ARHGAP12 p.Gln371Lys Uncertain significance Single submitter
- ARHGAP12 p.Gln67His Uncertain significance Single submitter
- ARHGAP12 p.Glu225Gln Uncertain significance Single submitter
- ARHGAP12 p.Glu362Lys Uncertain significance Single submitter
- ARHGAP12 p.Glu444Asp Uncertain significance Single submitter
- ARHGAP12 p.Gly178Ala Uncertain significance Single submitter
- ARHGAP12 p.Gly495Arg Uncertain significance Single submitter
- ARHGAP12 p.His352Arg Uncertain significance Single submitter
- ARHGAP12 p.Ile402Thr Uncertain significance Single submitter
- ARHGAP12 p.Ile585Asn Uncertain significance Single submitter
- ARHGAP12 p.Ile589Thr Uncertain significance Single submitter
- ARHGAP12 p.Ile595Val Uncertain significance Single submitter
- ARHGAP12 p.Ile791Thr Uncertain significance Single submitter
- ARHGAP12 p.Leu630Ser Uncertain significance Single submitter
- ARHGAP12 p.Lys480Ile Uncertain significance Single submitter
- ARHGAP12 p.Lys766Met Uncertain significance Single submitter
- ARHGAP12 p.Met78Val Uncertain significance Single submitter
- ARHGAP12 p.Pro119Ala Uncertain significance Single submitter
- ARHGAP12 p.Pro138Arg Uncertain significance Single submitter
- ARHGAP12 p.Pro183Ala Uncertain significance Single submitter
- ARHGAP12 p.Pro263Leu Uncertain significance Single submitter
- ARHGAP12 p.Pro295Arg Uncertain significance Single submitter
- ARHGAP12 p.Pro449Ala Uncertain significance Single submitter
- ARHGAP12 p.Ser115Gly Uncertain significance Single submitter
- ARHGAP12 p.Ser120Leu Uncertain significance Single submitter
- ARHGAP12 p.Ser163Leu Uncertain significance Single submitter
- ARHGAP12 p.Thr145Asn Uncertain significance Single submitter
- ARHGAP12 p.Thr299Ile Uncertain significance Single submitter
- ARHGAP12 p.Thr503Ser Uncertain significance Single submitter
- ARHGAP12 p.Thr92Pro Uncertain significance Single submitter
- ARHGAP12 p.Tyr325Cys Uncertain significance Single submitter
- ARHGAP12 p.Tyr329His Uncertain significance Single submitter
- ARHGAP12 p.Tyr376Cys Uncertain significance Single submitter
- ARHGAP12 p.Tyr691His Uncertain significance Single submitter
- ARHGAP12 p.Tyr801Cys Uncertain significance Single submitter
- ARHGAP12 p.Val522Ala Uncertain significance Single submitter
Predictors split 44
The independent predictors disagree with each other — read with care.
- ARHGAP12 p.Ala491Ser Uncertain significance Single submitter
- ARHGAP12 p.Ala698Thr Uncertain significance Single submitter
- ARHGAP12 p.Ala753Ser Uncertain significance Single submitter
- ARHGAP12 p.Arg383Gln Uncertain significance Single submitter
- ARHGAP12 p.Arg410Trp Uncertain significance Single submitter
- ARHGAP12 p.Arg548Cys Uncertain significance Single submitter
- ARHGAP12 p.Arg611Cys Uncertain significance Single submitter
- ARHGAP12 p.Arg6Gly Uncertain significance Single submitter
- ARHGAP12 p.Arg74Cys Uncertain significance Single submitter
- ARHGAP12 p.Arg74His Uncertain significance Single submitter
- ARHGAP12 p.Arg846Cys Uncertain significance Single submitter
- ARHGAP12 p.Arg846His Uncertain significance Single submitter
- ARHGAP12 p.Asn514His Uncertain significance Single submitter
- ARHGAP12 p.Asn657Ser Uncertain significance Single submitter
- ARHGAP12 p.Asn660Lys Uncertain significance Single submitter
- ARHGAP12 p.Asn708Ser Uncertain significance Single submitter
- ARHGAP12 p.Asn748Ile Uncertain significance Single submitter
- ARHGAP12 p.Asp560Asn Uncertain significance Single submitter
- ARHGAP12 p.Asp717Asn Uncertain significance Single submitter
- ARHGAP12 p.Gln549Pro Uncertain significance Single submitter
- ARHGAP12 p.Gln781His Uncertain significance Single submitter
- ARHGAP12 p.Glu387Lys Uncertain significance Single submitter
- ARHGAP12 p.Glu839Gln Uncertain significance Single submitter
- ARHGAP12 p.Ile563Thr Uncertain significance Single submitter
- ARHGAP12 p.Ile574Val Uncertain significance Single submitter
- ARHGAP12 p.Leu570Phe Uncertain significance Single submitter
- ARHGAP12 p.Leu640Ser Uncertain significance Single submitter
- ARHGAP12 p.Lys609Asn Uncertain significance Single submitter
- ARHGAP12 p.Lys814Asn Uncertain significance Single submitter
- ARHGAP12 p.Met780Val Uncertain significance Single submitter
- ARHGAP12 p.Phe543Leu Uncertain significance Single submitter
- ARHGAP12 p.Ser176Leu Likely benign Single submitter
- ARHGAP12 p.Ser192Ile Uncertain significance Single submitter
- ARHGAP12 p.Ser450Ala Uncertain significance Single submitter
- ARHGAP12 p.Ser459Asn Uncertain significance Single submitter
- ARHGAP12 p.Ser620Cys Uncertain significance Single submitter
- ARHGAP12 p.Ser803Asn Uncertain significance Single submitter
- ARHGAP12 p.Thr356Ala Uncertain significance Single submitter
- ARHGAP12 p.Thr819Ala Uncertain significance Single submitter
- ARHGAP12 p.Thr92Met Likely benign Single submitter
- ARHGAP12 p.Tyr801Phe Uncertain significance Single submitter
- ARHGAP12 p.Val15Met Uncertain significance Single submitter
- ARHGAP12 p.Val43Met Uncertain significance Single submitter
- ARHGAP12 p.Val482Phe Uncertain significance Single submitter
All ARHGAP12 variants
Benign 1
- p.Arg6= Multiple submitters
Likely benign 4
- p.Ile129Thr Single submitter
- p.Pro590= Single submitter
- p.Ser176Leu Single submitter ⚠
- p.Thr92Met Single submitter ⚠
Uncertain significance 96
- p.Ala393Val Single submitter ⚠
- p.Ala458Ser Single submitter ⚠
- p.Ala458Val Single submitter ⚠
- p.Ala491Ser Single submitter ⚠
- p.Ala491Val Single submitter ⚠
- p.Ala698Thr Single submitter ⚠
- p.Ala753Ser Single submitter ⚠
- p.Arg175His Single submitter ⚠
- p.Arg383Gln Single submitter ⚠
- p.Arg410Trp Single submitter ⚠
- p.Arg548Cys Single submitter ⚠
- p.Arg548His Single submitter ⚠
- p.Arg611Cys Single submitter ⚠
- p.Arg6Gly Single submitter ⚠
- p.Arg74Cys Single submitter ⚠
- p.Arg74His Single submitter ⚠
- p.Arg761Gln Single submitter ⚠
- p.Arg846Cys Single submitter ⚠
- p.Arg846His Single submitter ⚠
- p.Asn133Ser Single submitter ⚠
- p.Asn155Asp Single submitter ⚠
- p.Asn311Thr Single submitter ⚠
- p.Asn514His Single submitter ⚠
- p.Asn559Ser Single submitter ⚠
- p.Asn657Ser Single submitter ⚠
- p.Asn660Lys Single submitter ⚠
- p.Asn708Ser Single submitter ⚠
- p.Asn748Ile Single submitter ⚠
- p.Asp431Asn Single submitter ⚠
- p.Asp535Gly Single submitter ⚠
- p.Asp560Asn Single submitter ⚠
- p.Asp717Asn Single submitter ⚠
- p.Asp722His Single submitter ⚠
- p.Cys676Ser Single submitter ⚠
- p.Gln124Arg Single submitter ⚠
- p.Gln171Arg Single submitter ⚠
- p.Gln197Arg Single submitter ⚠
- p.Gln371Lys Single submitter ⚠
- p.Gln549Pro Single submitter ⚠
- p.Gln67His Single submitter ⚠
- p.Gln781His Single submitter ⚠
- p.Glu225Gln Single submitter ⚠
- p.Glu362Lys Single submitter ⚠
- p.Glu387Lys Single submitter ⚠
- p.Glu444Asp Single submitter ⚠
- p.Glu839Gln Single submitter ⚠
- p.Gly178Ala Single submitter ⚠
- p.Gly495Arg Single submitter ⚠
- p.His352Arg Single submitter ⚠
- p.Ile402Thr Single submitter ⚠
- p.Ile563Thr Single submitter ⚠
- p.Ile574Val Single submitter ⚠
- p.Ile585Asn Single submitter ⚠
- p.Ile589Thr Single submitter ⚠
- p.Ile595Val Single submitter ⚠
- p.Ile791Thr Single submitter ⚠
- p.Leu570Phe Single submitter ⚠
- p.Leu630Ser Single submitter ⚠
- p.Leu640Ser Single submitter ⚠
- p.Lys480Ile Single submitter ⚠
- p.Lys609Asn Single submitter ⚠
- p.Lys766Met Single submitter ⚠
- p.Lys814Asn Single submitter ⚠
- p.Met780Val Single submitter ⚠
- p.Met78Val Single submitter ⚠
- p.Phe543Leu Single submitter ⚠
- p.Pro119Ala Single submitter ⚠
- p.Pro138Arg Single submitter ⚠
- p.Pro183Ala Single submitter ⚠
- p.Pro263Leu Single submitter ⚠
- p.Pro295Arg Single submitter ⚠
- p.Pro449Ala Single submitter ⚠
- p.Ser115Gly Single submitter ⚠
- p.Ser120Leu Single submitter ⚠
- p.Ser163Leu Single submitter ⚠
- p.Ser192Ile Single submitter ⚠
- p.Ser450Ala Single submitter ⚠
- p.Ser459Asn Single submitter ⚠
- p.Ser620Cys Single submitter ⚠
- p.Ser803Asn Single submitter ⚠
- p.Thr145Asn Single submitter ⚠
- p.Thr299Ile Single submitter ⚠
- p.Thr356Ala Single submitter ⚠
- p.Thr503Ser Single submitter ⚠
- p.Thr819Ala Single submitter ⚠
- p.Thr92Pro Single submitter ⚠
- p.Tyr325Cys Single submitter ⚠
- p.Tyr329His Single submitter ⚠
- p.Tyr376Cys Single submitter ⚠
- p.Tyr691His Single submitter ⚠
- p.Tyr801Cys Single submitter ⚠
- p.Tyr801Phe Single submitter ⚠
- p.Val15Met Single submitter ⚠
- p.Val43Met Single submitter ⚠
- p.Val482Phe Single submitter ⚠
- p.Val522Ala Single submitter ⚠