ARHGAP15 — 74 ClinVar variants
All ClinVar germline ARHGAP15 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 70 flagged for review →
3 Likely benign · 71 Uncertain significance
Full ARHGAP15 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 70
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 40
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARHGAP15 p.Ala183Thr Uncertain significance Single submitter
- ARHGAP15 p.Ala242Thr Uncertain significance Single submitter
- ARHGAP15 p.Arg18Cys Uncertain significance Single submitter
- ARHGAP15 p.Arg200Ser Uncertain significance Single submitter
- ARHGAP15 p.Arg261Gln Uncertain significance Single submitter
- ARHGAP15 p.Arg317Gln Uncertain significance Single submitter
- ARHGAP15 p.Arg387Gly Uncertain significance Single submitter
- ARHGAP15 p.Arg387Ile Uncertain significance Single submitter
- ARHGAP15 p.Arg403His Uncertain significance Single submitter
- ARHGAP15 p.Asn15Lys Uncertain significance Single submitter
- ARHGAP15 p.Asn423Lys Uncertain significance Single submitter
- ARHGAP15 p.Asp313Gly Uncertain significance Single submitter
- ARHGAP15 p.Asp48Asn Uncertain significance Single submitter
- ARHGAP15 p.Asp93Glu Uncertain significance Single submitter
- ARHGAP15 p.Gln123His Uncertain significance Single submitter
- ARHGAP15 p.Gln455Arg Uncertain significance Single submitter
- ARHGAP15 p.Glu145Asp Uncertain significance Single submitter
- ARHGAP15 p.Glu166Gly Uncertain significance Single submitter
- ARHGAP15 p.Glu473Lys Uncertain significance Single submitter
- ARHGAP15 p.Gly141Arg Uncertain significance Single submitter
- ARHGAP15 p.His132Asn Uncertain significance Single submitter
- ARHGAP15 p.His143Arg Uncertain significance Single submitter
- ARHGAP15 p.Ile114Thr Uncertain significance Single submitter
- ARHGAP15 p.Ile278Leu Uncertain significance Single submitter
- ARHGAP15 p.Ile331Thr Uncertain significance Single submitter
- ARHGAP15 p.Ile379Asn Uncertain significance Single submitter
- ARHGAP15 p.Ile432Thr Uncertain significance Single submitter
- ARHGAP15 p.Ile458Thr Uncertain significance Single submitter
- ARHGAP15 p.Leu409Phe Uncertain significance Single submitter
- ARHGAP15 p.Lys51Asn Uncertain significance Single submitter
- ARHGAP15 p.Met235Ile Uncertain significance Single submitter
- ARHGAP15 p.Phe167Leu Uncertain significance Single submitter
- ARHGAP15 p.Pro400Leu Uncertain significance Single submitter
- ARHGAP15 p.Pro55Thr Uncertain significance Single submitter
- ARHGAP15 p.Ser152Arg Uncertain significance Single submitter
- ARHGAP15 p.Thr104Ala Uncertain significance Single submitter
- ARHGAP15 p.Thr13Pro Uncertain significance Single submitter
- ARHGAP15 p.Thr213Ala Uncertain significance Single submitter
- ARHGAP15 p.Thr53Ile Uncertain significance Single submitter
- ARHGAP15 p.Tyr219Asp Uncertain significance Single submitter
Predictors split 30
The independent predictors disagree with each other — read with care.
- ARHGAP15 p.Ala304Thr Uncertain significance Single submitter
- ARHGAP15 p.Ala420Pro Uncertain significance Single submitter
- ARHGAP15 p.Arg250Gln Uncertain significance Single submitter
- ARHGAP15 p.Arg289Cys Uncertain significance Single submitter
- ARHGAP15 p.Arg289His Uncertain significance Single submitter
- ARHGAP15 p.Arg440Gln Uncertain significance Single submitter
- ARHGAP15 p.Asn155His Uncertain significance Single submitter
- ARHGAP15 p.Asp48His Uncertain significance Single submitter
- ARHGAP15 p.Gln123Pro Uncertain significance Single submitter
- ARHGAP15 p.Gln87Arg Uncertain significance Single submitter
- ARHGAP15 p.Glu149Gly Uncertain significance Single submitter
- ARHGAP15 p.Glu76Lys Uncertain significance Single submitter
- ARHGAP15 p.Gly95Arg Uncertain significance Single submitter
- ARHGAP15 p.His143Tyr Uncertain significance Single submitter
- ARHGAP15 p.Ile177Thr Uncertain significance Single submitter
- ARHGAP15 p.Ile388Met Uncertain significance Single submitter
- ARHGAP15 p.Ile458Val Uncertain significance Single submitter
- ARHGAP15 p.Leu178Phe Uncertain significance Single submitter
- ARHGAP15 p.Lys407Glu Uncertain significance Single submitter
- ARHGAP15 p.Met452Val Uncertain significance Single submitter
- ARHGAP15 p.Pro192Arg Uncertain significance Single submitter
- ARHGAP15 p.Pro192Thr Uncertain significance Single submitter
- ARHGAP15 p.Ser103Phe Uncertain significance Single submitter
- ARHGAP15 p.Ser370Cys Uncertain significance Single submitter
- ARHGAP15 p.Thr260Asn Uncertain significance Single submitter
- ARHGAP15 p.Thr427Met Uncertain significance Single submitter
- ARHGAP15 p.Val251Ala Uncertain significance Single submitter
- ARHGAP15 p.Val251Gly Uncertain significance Single submitter
- ARHGAP15 p.Val286Met Uncertain significance Single submitter
- ARHGAP15 p.Val350Ile Uncertain significance Single submitter
All ARHGAP15 variants
Likely benign 3
- c.475-4G>T Single submitter
- p.Gly471Ser Single submitter
- p.Val71Ile Single submitter
Uncertain significance 71
- c.474+1G>A Single submitter
- p.Ala183Thr Single submitter ⚠
- p.Ala242Thr Single submitter ⚠
- p.Ala304Thr Single submitter ⚠
- p.Ala420Pro Single submitter ⚠
- p.Arg18Cys Single submitter ⚠
- p.Arg200Ser Single submitter ⚠
- p.Arg250Gln Single submitter ⚠
- p.Arg261Gln Single submitter ⚠
- p.Arg289Cys Single submitter ⚠
- p.Arg289His Single submitter ⚠
- p.Arg317Gln Single submitter ⚠
- p.Arg387Gly Single submitter ⚠
- p.Arg387Ile Single submitter ⚠
- p.Arg403His Single submitter ⚠
- p.Arg440Gln Single submitter ⚠
- p.Asn155His Single submitter ⚠
- p.Asn15Lys Single submitter ⚠
- p.Asn423Lys Single submitter ⚠
- p.Asp313Gly Single submitter ⚠
- p.Asp48Asn Single submitter ⚠
- p.Asp48His Single submitter ⚠
- p.Asp93Glu Single submitter ⚠
- p.Gln123His Single submitter ⚠
- p.Gln123Pro Single submitter ⚠
- p.Gln455Arg Single submitter ⚠
- p.Gln87Arg Single submitter ⚠
- p.Glu145Asp Single submitter ⚠
- p.Glu149Gly Single submitter ⚠
- p.Glu166Gly Single submitter ⚠
- p.Glu473Lys Single submitter ⚠
- p.Glu76Lys Single submitter ⚠
- p.Gly141Arg Single submitter ⚠
- p.Gly95Arg Single submitter ⚠
- p.His132Asn Single submitter ⚠
- p.His143Arg Single submitter ⚠
- p.His143Tyr Single submitter ⚠
- p.Ile114Thr Single submitter ⚠
- p.Ile177Thr Single submitter ⚠
- p.Ile278Leu Single submitter ⚠
- p.Ile331Thr Single submitter ⚠
- p.Ile379Asn Single submitter ⚠
- p.Ile388Met Single submitter ⚠
- p.Ile432Thr Single submitter ⚠
- p.Ile458Thr Single submitter ⚠
- p.Ile458Val Single submitter ⚠
- p.Leu178Phe Single submitter ⚠
- p.Leu409Phe Single submitter ⚠
- p.Lys407Glu Single submitter ⚠
- p.Lys51Asn Single submitter ⚠
- p.Met235Ile Single submitter ⚠
- p.Met452Val Single submitter ⚠
- p.Phe167Leu Single submitter ⚠
- p.Pro192Arg Single submitter ⚠
- p.Pro192Thr Single submitter ⚠
- p.Pro400Leu Single submitter ⚠
- p.Pro55Thr Single submitter ⚠
- p.Ser103Phe Single submitter ⚠
- p.Ser152Arg Single submitter ⚠
- p.Ser370Cys Single submitter ⚠
- p.Thr104Ala Single submitter ⚠
- p.Thr13Pro Single submitter ⚠
- p.Thr213Ala Single submitter ⚠
- p.Thr260Asn Single submitter ⚠
- p.Thr427Met Single submitter ⚠
- p.Thr53Ile Single submitter ⚠
- p.Tyr219Asp Single submitter ⚠
- p.Val251Ala Single submitter ⚠
- p.Val251Gly Single submitter ⚠
- p.Val286Met Single submitter ⚠
- p.Val350Ile Single submitter ⚠