ARHGAP20 — 144 ClinVar variants
All ClinVar germline ARHGAP20 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 137 flagged for review →
8 Likely benign · 136 Uncertain significance
Full ARHGAP20 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 137
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 78
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARHGAP20 p.Ala1056Gly Uncertain significance Single submitter
- ARHGAP20 p.Ala1077Gly Uncertain significance Single submitter
- ARHGAP20 p.Ala222Val Uncertain significance Single submitter
- ARHGAP20 p.Ala316Thr Uncertain significance Single submitter
- ARHGAP20 p.Ala317Pro Uncertain significance Single submitter
- ARHGAP20 p.Ala689Val Uncertain significance Single submitter
- ARHGAP20 p.Ala68Thr Uncertain significance Single submitter
- ARHGAP20 p.Ala995Thr Uncertain significance Single submitter
- ARHGAP20 p.Arg1185Gly Uncertain significance Single submitter
- ARHGAP20 p.Arg301Gln Uncertain significance Single submitter
- ARHGAP20 p.Arg301Leu Uncertain significance Single submitter
- ARHGAP20 p.Arg63Gly Uncertain significance Single submitter
- ARHGAP20 p.Arg855Leu Uncertain significance Single submitter
- ARHGAP20 p.Arg855Pro Uncertain significance Single submitter
- ARHGAP20 p.Arg91Gln Uncertain significance Single submitter
- ARHGAP20 p.Asn121Ser Uncertain significance Single submitter
- ARHGAP20 p.Asn149Ser Uncertain significance Single submitter
- ARHGAP20 p.Asn247Ser Uncertain significance Single submitter
- ARHGAP20 p.Asn468His Uncertain significance Single submitter
- ARHGAP20 p.Asp1117Asn Uncertain significance Single submitter
- ARHGAP20 p.Asp348Asn Uncertain significance Single submitter
- ARHGAP20 p.Asp449Ala Uncertain significance Single submitter
- ARHGAP20 p.Asp597Asn Uncertain significance Single submitter
- ARHGAP20 p.Cys305Arg Uncertain significance Single submitter
- ARHGAP20 p.Cys32Tyr Uncertain significance Single submitter
- ARHGAP20 p.Gln318Pro Uncertain significance Single submitter
- ARHGAP20 p.Glu1061Lys Uncertain significance Single submitter
- ARHGAP20 p.Glu1089Gly Uncertain significance Single submitter
- ARHGAP20 p.Glu297Gly Uncertain significance Single submitter
- ARHGAP20 p.Glu419Lys Uncertain significance Single submitter
- ARHGAP20 p.Glu531Lys Uncertain significance Single submitter
- ARHGAP20 p.Glu553Asp Uncertain significance Single submitter
- ARHGAP20 p.Glu570Gly Uncertain significance Single submitter
- ARHGAP20 p.Gly1000Arg Uncertain significance Single submitter
- ARHGAP20 p.Gly1003Ser Uncertain significance Single submitter
- ARHGAP20 p.Gly29Val Uncertain significance Single submitter
- ARHGAP20 p.Gly608Ser Uncertain significance Single submitter
- ARHGAP20 p.Gly947Ser Uncertain significance Single submitter
- ARHGAP20 p.Gly947Val Uncertain significance Single submitter
- ARHGAP20 p.His789Tyr Uncertain significance Single submitter
- ARHGAP20 p.Ile334Val Uncertain significance Single submitter
- ARHGAP20 p.Ile708Val Uncertain significance Single submitter
- ARHGAP20 p.Leu1135Gln Uncertain significance Single submitter
- ARHGAP20 p.Leu11Pro Uncertain significance Single submitter
- ARHGAP20 p.Leu295Pro Uncertain significance Single submitter
- ARHGAP20 p.Leu40Val Uncertain significance Single submitter
- ARHGAP20 p.Leu603Phe Uncertain significance Single submitter
- ARHGAP20 p.Lys1046Arg Uncertain significance Single submitter
- ARHGAP20 p.Lys1051Arg Uncertain significance Single submitter
- ARHGAP20 p.Lys34Arg Uncertain significance Single submitter
- ARHGAP20 p.Lys378Thr Uncertain significance Single submitter
- ARHGAP20 p.Met151Val Uncertain significance Single submitter
- ARHGAP20 p.Met228Thr Uncertain significance Single submitter
- ARHGAP20 p.Phe1126Leu Uncertain significance Single submitter
- ARHGAP20 p.Phe288Leu Uncertain significance Single submitter
- ARHGAP20 p.Pro1074His Uncertain significance Single submitter
- ARHGAP20 p.Pro1172Ser Uncertain significance Single submitter
- ARHGAP20 p.Pro1176Ser Uncertain significance Single submitter
- ARHGAP20 p.Pro256Arg Uncertain significance Single submitter
- ARHGAP20 p.Pro300Ser Uncertain significance Single submitter
- ARHGAP20 p.Pro628Thr Uncertain significance Single submitter
- ARHGAP20 p.Pro808Ser Uncertain significance Single submitter
- ARHGAP20 p.Pro941Ser Uncertain significance Single submitter
- ARHGAP20 p.Ser1149Arg Uncertain significance Single submitter
- ARHGAP20 p.Ser312Cys Uncertain significance Single submitter
- ARHGAP20 p.Ser353Pro Uncertain significance Single submitter
- ARHGAP20 p.Ser696Arg Uncertain significance Single submitter
- ARHGAP20 p.Ser716Ala Uncertain significance Single submitter
- ARHGAP20 p.Tyr210Cys Uncertain significance Single submitter
- ARHGAP20 p.Tyr685Cys Uncertain significance Single submitter
- ARHGAP20 p.Val1129Ala Uncertain significance Single submitter
- ARHGAP20 p.Val596Ile Uncertain significance Single submitter
- ARHGAP20 p.Val664Ala Uncertain significance Single submitter
- ARHGAP20 p.Val767Leu Uncertain significance Single submitter
- ARHGAP20 p.Val799Ala Uncertain significance Single submitter
- ARHGAP20 p.Val965Gly Uncertain significance Single submitter
- ARHGAP20 p.Val998Phe Uncertain significance Single submitter
-
ARHGAP20 p.Val155Ala
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 59
The independent predictors disagree with each other — read with care.
- ARHGAP20 p.Ala202Thr Uncertain significance Single submitter
- ARHGAP20 p.Ala41Pro Uncertain significance Single submitter
- ARHGAP20 p.Ala691Pro Uncertain significance Single submitter
- ARHGAP20 p.Arg103Gln Uncertain significance Single submitter
- ARHGAP20 p.Arg341Gln Uncertain significance Single submitter
- ARHGAP20 p.Arg486Ser Uncertain significance Single submitter
- ARHGAP20 p.Arg671Trp Uncertain significance Single submitter
- ARHGAP20 p.Arg843Gln Uncertain significance Single submitter
- ARHGAP20 p.Arg844His Uncertain significance Single submitter
- ARHGAP20 p.Arg855Cys Likely benign Single submitter
- ARHGAP20 p.Arg855His Uncertain significance Single submitter
- ARHGAP20 p.Arg91Gly Uncertain significance Single submitter
- ARHGAP20 p.Arg985Trp Uncertain significance Single submitter
- ARHGAP20 p.Asn122Lys Uncertain significance Single submitter
- ARHGAP20 p.Asn900Tyr Uncertain significance Single submitter
- ARHGAP20 p.Asp709Asn Uncertain significance Single submitter
- ARHGAP20 p.Asp766His Uncertain significance Single submitter
- ARHGAP20 p.Gln747His Uncertain significance Single submitter
- ARHGAP20 p.Glu102Asp Uncertain significance Single submitter
- ARHGAP20 p.Glu1061Asp Uncertain significance Single submitter
- ARHGAP20 p.Glu851Val Uncertain significance Single submitter
- ARHGAP20 p.Glu882Lys Uncertain significance Single submitter
- ARHGAP20 p.His325Tyr Uncertain significance Single submitter
- ARHGAP20 p.His842Tyr Uncertain significance Single submitter
- ARHGAP20 p.Ile184Leu Uncertain significance Single submitter
- ARHGAP20 p.Ile51Thr Uncertain significance Single submitter
- ARHGAP20 p.Ile850Met Uncertain significance Single submitter
- ARHGAP20 p.Ile850Thr Uncertain significance Single submitter
- ARHGAP20 p.Ile863Thr Uncertain significance Single submitter
- ARHGAP20 p.Ile88Thr Uncertain significance Single submitter
- ARHGAP20 p.Leu558Phe Uncertain significance Single submitter
- ARHGAP20 p.Leu857Gln Uncertain significance Single submitter
- ARHGAP20 p.Leu877Phe Uncertain significance Single submitter
- ARHGAP20 p.Leu885His Uncertain significance Single submitter
- ARHGAP20 p.Leu929Phe Uncertain significance Single submitter
- ARHGAP20 p.Leu94Phe Uncertain significance Single submitter
- ARHGAP20 p.Lys866Glu Uncertain significance Single submitter
- ARHGAP20 p.Phe507Leu Uncertain significance Single submitter
- ARHGAP20 p.Pro1125Thr Uncertain significance Single submitter
- ARHGAP20 p.Pro300Leu Uncertain significance Single submitter
- ARHGAP20 p.Pro654Ala Uncertain significance Single submitter
- ARHGAP20 p.Pro659Leu Uncertain significance Single submitter
- ARHGAP20 p.Pro669Thr Uncertain significance Single submitter
- ARHGAP20 p.Pro819His Uncertain significance Single submitter
- ARHGAP20 p.Ser20Phe Uncertain significance Single submitter
- ARHGAP20 p.Ser343Cys Uncertain significance Single submitter
- ARHGAP20 p.Ser344Gly Uncertain significance Single submitter
- ARHGAP20 p.Ser353Leu Uncertain significance Single submitter
- ARHGAP20 p.Ser432Cys Uncertain significance Single submitter
- ARHGAP20 p.Ser5Phe Uncertain significance Single submitter
- ARHGAP20 p.Ser5Pro Uncertain significance Single submitter
- ARHGAP20 p.Ser687Ala Uncertain significance Single submitter
- ARHGAP20 p.Ser760Asn Uncertain significance Single submitter
- ARHGAP20 p.Ser796Cys Uncertain significance Single submitter
- ARHGAP20 p.Ser872Arg Uncertain significance Single submitter
- ARHGAP20 p.Ser902Asn Uncertain significance Single submitter
- ARHGAP20 p.Ser989Cys Uncertain significance Single submitter
- ARHGAP20 p.Thr22Ile Uncertain significance Single submitter
- ARHGAP20 p.Val664Met Uncertain significance Single submitter
All ARHGAP20 variants
Likely benign 8
- p.Ala1169Val Single submitter
- p.Arg1012His Single submitter
- p.Arg182= Single submitter
- p.Arg855Cys Single submitter ⚠
- p.Asn83Ser Single submitter
- p.Ile1064Thr Single submitter
- p.Met809Val Single submitter
- p.Val790Met Single submitter
Uncertain significance 136
- p.Ala1056Gly Single submitter ⚠
- p.Ala1077Gly Single submitter ⚠
- p.Ala202Thr Single submitter ⚠
- p.Ala222Val Single submitter ⚠
- p.Ala316Thr Single submitter ⚠
- p.Ala317Pro Single submitter ⚠
- p.Ala41Pro Single submitter ⚠
- p.Ala689Val Single submitter ⚠
- p.Ala68Thr Single submitter ⚠
- p.Ala691Pro Single submitter ⚠
- p.Ala995Thr Single submitter ⚠
- p.Arg103Gln Single submitter ⚠
- p.Arg1185Gly Single submitter ⚠
- p.Arg301Gln Single submitter ⚠
- p.Arg301Leu Single submitter ⚠
- p.Arg341Gln Single submitter ⚠
- p.Arg486Ser Single submitter ⚠
- p.Arg63Gly Single submitter ⚠
- p.Arg671Trp Single submitter ⚠
- p.Arg843Gln Single submitter ⚠
- p.Arg844His Single submitter ⚠
- p.Arg855His Single submitter ⚠
- p.Arg855Leu Single submitter ⚠
- p.Arg855Pro Single submitter ⚠
- p.Arg91Gln Single submitter ⚠
- p.Arg91Gly Single submitter ⚠
- p.Arg985Trp Single submitter ⚠
- p.Asn121Ser Single submitter ⚠
- p.Asn122Lys Single submitter ⚠
- p.Asn149Ser Single submitter ⚠
- p.Asn247Ser Single submitter ⚠
- p.Asn468His Single submitter ⚠
- p.Asn900Tyr Single submitter ⚠
- p.Asp1117Asn Single submitter ⚠
- p.Asp348Asn Single submitter ⚠
- p.Asp449Ala Single submitter ⚠
- p.Asp597Asn Single submitter ⚠
- p.Asp709Asn Single submitter ⚠
- p.Asp766His Single submitter ⚠
- p.Cys305Arg Single submitter ⚠
- p.Cys32Tyr Single submitter ⚠
- p.Gln318Pro Single submitter ⚠
- p.Gln747His Single submitter ⚠
- p.Glu102Asp Single submitter ⚠
- p.Glu1061Asp Single submitter ⚠
- p.Glu1061Lys Single submitter ⚠
- p.Glu1089Gly Single submitter ⚠
- p.Glu297Gly Single submitter ⚠
- p.Glu419Lys Single submitter ⚠
- p.Glu531Lys Single submitter ⚠
- p.Glu553Asp Single submitter ⚠
- p.Glu570Gly Single submitter ⚠
- p.Glu851Val Single submitter ⚠
- p.Glu882Lys Single submitter ⚠
- p.Gly1000Arg Single submitter ⚠
- p.Gly1003Ser Single submitter ⚠
- p.Gly29Val Single submitter ⚠
- p.Gly608Ser Single submitter ⚠
- p.Gly947Ser Single submitter ⚠
- p.Gly947Val Single submitter ⚠
- p.His325Tyr Single submitter ⚠
- p.His789Tyr Single submitter ⚠
- p.His842Tyr Single submitter ⚠
- p.Ile184Leu Single submitter ⚠
- p.Ile334Val Single submitter ⚠
- p.Ile51Thr Single submitter ⚠
- p.Ile708Val Single submitter ⚠
- p.Ile850Met Single submitter ⚠
- p.Ile850Thr Single submitter ⚠
- p.Ile863Thr Single submitter ⚠
- p.Ile88Thr Single submitter ⚠
- p.Leu1135Gln Single submitter ⚠
- p.Leu11Pro Single submitter ⚠
- p.Leu295Pro Single submitter ⚠
- p.Leu40Val Single submitter ⚠
- p.Leu558Phe Single submitter ⚠
- p.Leu603Phe Single submitter ⚠
- p.Leu857Gln Single submitter ⚠
- p.Leu877Phe Single submitter ⚠
- p.Leu885His Single submitter ⚠
- p.Leu929Phe Single submitter ⚠
- p.Leu94Phe Single submitter ⚠
- p.Lys1046Arg Single submitter ⚠
- p.Lys1051Arg Single submitter ⚠
- p.Lys34Arg Single submitter ⚠
- p.Lys378Thr Single submitter ⚠
- p.Lys866Glu Single submitter ⚠
- p.Met151Val Single submitter ⚠
- p.Met228Thr Single submitter ⚠
- p.Phe1126Leu Single submitter ⚠
- p.Phe288Leu Single submitter ⚠
- p.Phe507Leu Single submitter ⚠
- p.Pro1074His Single submitter ⚠
- p.Pro1125Thr Single submitter ⚠
- p.Pro1172Ser Single submitter ⚠
- p.Pro1176Ser Single submitter ⚠
- p.Pro256Arg Single submitter ⚠
- p.Pro300Leu Single submitter ⚠
- p.Pro300Ser Single submitter ⚠
- p.Pro628Thr Single submitter ⚠
- p.Pro654Ala Single submitter ⚠
- p.Pro659Leu Single submitter ⚠
- p.Pro669Thr Single submitter ⚠
- p.Pro808Ser Single submitter ⚠
- p.Pro819His Single submitter ⚠
- p.Pro941Ser Single submitter ⚠
- p.Ser1149Arg Single submitter ⚠
- p.Ser20Phe Single submitter ⚠
- p.Ser312Cys Single submitter ⚠
- p.Ser343Cys Single submitter ⚠
- p.Ser344Gly Single submitter ⚠
- p.Ser353Leu Single submitter ⚠
- p.Ser353Pro Single submitter ⚠
- p.Ser432Cys Single submitter ⚠
- p.Ser5Phe Single submitter ⚠
- p.Ser5Pro Single submitter ⚠
- p.Ser687Ala Single submitter ⚠
- p.Ser696Arg Single submitter ⚠
- p.Ser716Ala Single submitter ⚠
- p.Ser760Asn Single submitter ⚠
- p.Ser796Cys Single submitter ⚠
- p.Ser872Arg Single submitter ⚠
- p.Ser902Asn Single submitter ⚠
- p.Ser989Cys Single submitter ⚠
- p.Thr22Ile Single submitter ⚠
- p.Tyr210Cys Single submitter ⚠
- p.Tyr685Cys Single submitter ⚠
- p.Val1129Ala Single submitter ⚠
- p.Val596Ile Single submitter ⚠
- p.Val664Ala Single submitter ⚠
- p.Val664Met Single submitter ⚠
- p.Val767Leu Single submitter ⚠
- p.Val799Ala Single submitter ⚠
- p.Val965Gly Single submitter ⚠
- p.Val998Phe Single submitter ⚠
- p.Val155Ala No assertion criteria prostate cancer ⚠