ARL15 — 15 ClinVar variants
All ClinVar germline ARL15 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 10 flagged for review →
1 Benign · 14 Uncertain significance
Full ARL15 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 10
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 8
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARL15 p.Glu162Gln Uncertain significance Single submitter
- ARL15 p.Glu32Val Uncertain significance Single submitter
- ARL15 p.Gly42Ser Uncertain significance Single submitter
- ARL15 p.Ile77Val Uncertain significance Single submitter
- ARL15 p.Leu116Ser Uncertain significance Single submitter
- ARL15 p.Ser2Phe Uncertain significance Single submitter
- ARL15 p.Ser94Asn Uncertain significance Single submitter
- ARL15 p.Val80Ile Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All ARL15 variants
Benign 1
- p.Arg5= No assertion criteria ARL15-related disorder
Uncertain significance 14
- c.253+3A>T Single submitter ARL15-related disorder
- p.Arg30Gln Single submitter
- p.Asn142Ser Single submitter ⚠
- p.Glu117Lys Single submitter
- p.Glu162Gln Single submitter ⚠
- p.Glu32Val Single submitter ⚠
- p.Gly167Arg Single submitter ⚠
- p.Gly42Ser Single submitter ⚠
- p.Ile77Val Single submitter ⚠
- p.Leu116Ser Single submitter ⚠
- p.Lys24Glu Single submitter
- p.Ser2Phe Single submitter ⚠
- p.Ser94Asn Single submitter ⚠
- p.Val80Ile Single submitter ⚠