ARL5A — 20 ClinVar variants
All ClinVar germline ARL5A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 20 flagged for review →
20 Uncertain significance
Full ARL5A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 20
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARL5A p.Arg10Lys Uncertain significance Single submitter
- ARL5A p.Arg175Gln Uncertain significance Single submitter
- ARL5A p.Arg74His Uncertain significance Single submitter
- ARL5A p.Arg98Ser Uncertain significance Single submitter
- ARL5A p.Asn13Ser Uncertain significance Single submitter
- ARL5A p.Asn58Asp Uncertain significance Single submitter
- ARL5A p.Asn78Asp Uncertain significance Single submitter
- ARL5A p.Gln151His Uncertain significance Single submitter
- ARL5A p.Leu73Phe Uncertain significance Single submitter
- ARL5A p.Met38Val Uncertain significance Single submitter
- ARL5A p.Pro46Ser Uncertain significance Single submitter
- ARL5A p.Thr79Ile Uncertain significance Single submitter
- ARL5A p.Tyr81Cys Uncertain significance Single submitter
- ARL5A p.Val42Ala Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- ARL5A p.Arg61Cys Uncertain significance Single submitter
- ARL5A p.Asp149Tyr Uncertain significance Single submitter
- ARL5A p.Glu71Gln Uncertain significance Single submitter
- ARL5A p.Leu176Phe Uncertain significance Single submitter
- ARL5A p.Phe12Leu Uncertain significance Single submitter
- ARL5A p.Trp9Arg Uncertain significance Single submitter
All ARL5A variants
Uncertain significance 20
- p.Arg10Lys Single submitter ⚠
- p.Arg175Gln Single submitter ⚠
- p.Arg61Cys Single submitter ⚠
- p.Arg74His Single submitter ⚠
- p.Arg98Ser Single submitter ⚠
- p.Asn13Ser Single submitter ⚠
- p.Asn58Asp Single submitter ⚠
- p.Asn78Asp Single submitter ⚠
- p.Asp149Tyr Single submitter ⚠
- p.Gln151His Single submitter ⚠
- p.Glu71Gln Single submitter ⚠
- p.Leu176Phe Single submitter ⚠
- p.Leu73Phe Single submitter ⚠
- p.Met38Val Single submitter ⚠
- p.Phe12Leu Single submitter ⚠
- p.Pro46Ser Single submitter ⚠
- p.Thr79Ile Single submitter ⚠
- p.Trp9Arg Single submitter ⚠
- p.Tyr81Cys Single submitter ⚠
- p.Val42Ala Single submitter ⚠