ARL8A — 8 ClinVar variants
All ClinVar germline ARL8A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 6 flagged for review →
2 Benign · 6 Uncertain significance
Full ARL8A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 6
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 4
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 2
The independent predictors disagree with each other — read with care.
All ARL8A variants
Uncertain significance 6
- p.Ala3Thr Single submitter ⚠
- p.Arg58Ser Single submitter ⚠
- p.Asp100Gly Single submitter ⚠
- p.Glu156Gln Single submitter ⚠
- p.Ile2Met Single submitter ⚠
- p.Val93Met Single submitter ⚠