ARMC10 — 52 ClinVar variants
All ClinVar germline ARMC10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 48 flagged for review →
2 Likely benign · 50 Uncertain significance
Full ARMC10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 48
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 40
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARMC10 p.Ala126Pro Uncertain significance Single submitter
- ARMC10 p.Ala132Ser Uncertain significance Single submitter
- ARMC10 p.Ala198Thr Uncertain significance Single submitter
- ARMC10 p.Ala298Gly Uncertain significance Single submitter
- ARMC10 p.Ala330Gly Uncertain significance Single submitter
- ARMC10 p.Ala7Gly Uncertain significance Single submitter
- ARMC10 p.Arg33Trp Uncertain significance Single submitter
- ARMC10 p.Asn148Thr Uncertain significance Single submitter
- ARMC10 p.Asn233Lys Uncertain significance Single submitter
- ARMC10 p.Asn233Tyr Uncertain significance Single submitter
- ARMC10 p.Asp261Glu Uncertain significance Single submitter
- ARMC10 p.Asp83Glu Uncertain significance Single submitter
- ARMC10 p.Asp86Ala Uncertain significance Single submitter
- ARMC10 p.Cys183Arg Uncertain significance Single submitter
- ARMC10 p.Gln300Pro Uncertain significance Single submitter
- ARMC10 p.Glu55Val Uncertain significance Single submitter
- ARMC10 p.Gly2Val Uncertain significance Single submitter
- ARMC10 p.Gly3Asp Uncertain significance Single submitter
- ARMC10 p.Gly3Ser Uncertain significance Single submitter
- ARMC10 p.Ile114Thr Uncertain significance Single submitter
- ARMC10 p.Ile24Leu Uncertain significance Single submitter
- ARMC10 p.Ile339Val Uncertain significance Single submitter
- ARMC10 p.Met206Val Uncertain significance Single submitter
- ARMC10 p.Met251Thr Uncertain significance Single submitter
- ARMC10 p.Pro111Ser Uncertain significance Single submitter
- ARMC10 p.Pro141Arg Uncertain significance Single submitter
- ARMC10 p.Pro249Thr Uncertain significance Single submitter
- ARMC10 p.Ser150Thr Uncertain significance Single submitter
- ARMC10 p.Ser166Arg Uncertain significance Single submitter
- ARMC10 p.Ser180Arg Uncertain significance Single submitter
- ARMC10 p.Ser42Tyr Uncertain significance Single submitter
- ARMC10 p.Ser62Leu Uncertain significance Single submitter
- ARMC10 p.Ser76Ala Uncertain significance Single submitter
- ARMC10 p.Thr120Ile Uncertain significance Single submitter
- ARMC10 p.Thr204Ala Uncertain significance Single submitter
- ARMC10 p.Thr204Ile Uncertain significance Single submitter
- ARMC10 p.Thr207Ser Uncertain significance Single submitter
- ARMC10 p.Thr234Met Uncertain significance Single submitter
- ARMC10 p.Val272Ile Uncertain significance Single submitter
- ARMC10 p.Val336Ile Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- ARMC10 p.Arg279Gln Uncertain significance Single submitter
- ARMC10 p.Arg5Trp Uncertain significance Single submitter
- ARMC10 p.Cys23Arg Uncertain significance Single submitter
- ARMC10 p.Leu102Phe Uncertain significance Single submitter
- ARMC10 p.Leu239Val Uncertain significance Single submitter
- ARMC10 p.Ser263Pro Uncertain significance Single submitter
- ARMC10 p.Thr108Met Uncertain significance Single submitter
- ARMC10 p.Val336Phe Uncertain significance Single submitter
All ARMC10 variants
Likely benign 2
- p.Ala144Gly Single submitter
- p.Arg257His Single submitter
Uncertain significance 50
- p.Ala126Pro Single submitter ⚠
- p.Ala132Ser Single submitter ⚠
- p.Ala198Thr Single submitter ⚠
- p.Ala298Gly Single submitter ⚠
- p.Ala330Gly Single submitter ⚠
- p.Ala7Gly Single submitter ⚠
- p.Arg279Gln Single submitter ⚠
- p.Arg33Trp Single submitter ⚠
- p.Arg5Trp Single submitter ⚠
- p.Asn148Thr Single submitter ⚠
- p.Asn233Lys Single submitter ⚠
- p.Asn233Tyr Single submitter ⚠
- p.Asp261Glu Single submitter ⚠
- p.Asp83Glu Single submitter ⚠
- p.Asp86Ala Single submitter ⚠
- p.Cys183Arg Single submitter ⚠
- p.Cys23Arg Single submitter ⚠
- p.Cys317Arg Single submitter
- p.Gln300Pro Single submitter ⚠
- p.Glu55Val Single submitter ⚠
- p.Gly2Val Single submitter ⚠
- p.Gly3Asp Single submitter ⚠
- p.Gly3Ser Single submitter ⚠
- p.Ile114Thr Single submitter ⚠
- p.Ile24Leu Single submitter ⚠
- p.Ile339Val Single submitter ⚠
- p.Leu102Phe Single submitter ⚠
- p.Leu239Val Single submitter ⚠
- p.Met206Val Single submitter ⚠
- p.Met251Thr Single submitter ⚠
- p.Pro111Ser Single submitter ⚠
- p.Pro141Arg Single submitter ⚠
- p.Pro249Thr Single submitter ⚠
- p.Ser150Thr Single submitter ⚠
- p.Ser166Arg Single submitter ⚠
- p.Ser180Arg Single submitter ⚠
- p.Ser263Pro Single submitter ⚠
- p.Ser42Tyr Single submitter ⚠
- p.Ser62Leu Single submitter ⚠
- p.Ser76Ala Single submitter ⚠
- p.Thr108Met Single submitter ⚠
- p.Thr120Ile Single submitter ⚠
- p.Thr204Ala Single submitter ⚠
- p.Thr204Ile Single submitter ⚠
- p.Thr207Ser Single submitter ⚠
- p.Thr234Met Single submitter ⚠
- p.Val208Ala Single submitter
- p.Val272Ile Single submitter ⚠
- p.Val336Ile Single submitter ⚠
- p.Val336Phe Single submitter ⚠