ARMC8 — 54 ClinVar variants
All ClinVar germline ARMC8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 54 flagged for review →
54 Uncertain significance
Full ARMC8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 54
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARMC8 p.Arg159Lys Uncertain significance Single submitter
- ARMC8 p.Arg161His Uncertain significance Single submitter
- ARMC8 p.Arg270Gln Uncertain significance Single submitter
- ARMC8 p.Arg376Trp Uncertain significance Single submitter
- ARMC8 p.Cys621Tyr Uncertain significance Single submitter
- ARMC8 p.Gln207Glu Uncertain significance Single submitter
- ARMC8 p.Glu95Lys Uncertain significance Single submitter
- ARMC8 p.His105Arg Uncertain significance Single submitter
- ARMC8 p.His552Tyr Uncertain significance Single submitter
- ARMC8 p.Ile122Val Uncertain significance Single submitter
- ARMC8 p.Ile132Thr Uncertain significance Single submitter
- ARMC8 p.Ile320Val Uncertain significance Single submitter
- ARMC8 p.Ile563Thr Uncertain significance Single submitter
- ARMC8 p.Ile579Leu Uncertain significance Single submitter
- ARMC8 p.Ile599Val Uncertain significance Single submitter
- ARMC8 p.Leu102Arg Uncertain significance Single submitter
- ARMC8 p.Leu110Phe Uncertain significance Single submitter
- ARMC8 p.Leu119Pro Uncertain significance Single submitter
- ARMC8 p.Leu293Val Uncertain significance Single submitter
- ARMC8 p.Leu525Val Uncertain significance Single submitter
- ARMC8 p.Met666Ile Uncertain significance Single submitter
- ARMC8 p.Met666Val Uncertain significance Single submitter
- ARMC8 p.Met92Val Uncertain significance Single submitter
- ARMC8 p.Pro220Leu Uncertain significance Single submitter
- ARMC8 p.Pro249Ser Uncertain significance Single submitter
- ARMC8 p.Pro310Arg Uncertain significance Single submitter
- ARMC8 p.Thr134Ser Uncertain significance Single submitter
- ARMC8 p.Thr271Ala Uncertain significance Single submitter
- ARMC8 p.Thr271Arg Uncertain significance Single submitter
- ARMC8 p.Trp627Cys Uncertain significance Single submitter
- ARMC8 p.Val231Ile Uncertain significance Single submitter
- ARMC8 p.Val312Phe Uncertain significance Single submitter
- ARMC8 p.Val470Ile Uncertain significance Single submitter
- ARMC8 p.Val560Ile Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- ARMC8 p.Ala403Thr Uncertain significance Single submitter
- ARMC8 p.Ala469Thr Uncertain significance Single submitter
- ARMC8 p.Arg270Trp Uncertain significance Single submitter
- ARMC8 p.Arg542Cys Uncertain significance Single submitter
- ARMC8 p.Asp591His Uncertain significance Single submitter
- ARMC8 p.Glu296Gln Uncertain significance Single submitter
- ARMC8 p.Glu356Lys Uncertain significance Single submitter
- ARMC8 p.Gly188Ser Uncertain significance Single submitter
- ARMC8 p.His180Arg Uncertain significance Single submitter
- ARMC8 p.Ile41Met Uncertain significance Single submitter
- ARMC8 p.Lys378Glu Uncertain significance Single submitter
- ARMC8 p.Met43Val Uncertain significance Single submitter
- ARMC8 p.Phe121Leu Uncertain significance Single submitter
- ARMC8 p.Pro108Ala Uncertain significance Single submitter
- ARMC8 p.Pro31Ala Uncertain significance Single submitter
- ARMC8 p.Ser510Gly Uncertain significance Single submitter
- ARMC8 p.Ser550Gly Uncertain significance Single submitter
- ARMC8 p.Thr198Ile Uncertain significance Single submitter
- ARMC8 p.Tyr306Cys Uncertain significance Single submitter
- ARMC8 p.Tyr605Cys Uncertain significance Single submitter
All ARMC8 variants
Uncertain significance 54
- p.Ala403Thr Single submitter ⚠
- p.Ala469Thr Single submitter ⚠
- p.Arg159Lys Single submitter ⚠
- p.Arg161His Single submitter ⚠
- p.Arg270Gln Single submitter ⚠
- p.Arg270Trp Single submitter ⚠
- p.Arg376Trp Single submitter ⚠
- p.Arg542Cys Single submitter ⚠
- p.Asp591His Single submitter ⚠
- p.Cys621Tyr Single submitter ⚠
- p.Gln207Glu Single submitter ⚠
- p.Glu296Gln Single submitter ⚠
- p.Glu356Lys Single submitter ⚠
- p.Glu95Lys Single submitter ⚠
- p.Gly188Ser Single submitter ⚠
- p.His105Arg Single submitter ⚠
- p.His180Arg Single submitter ⚠
- p.His552Tyr Single submitter ⚠
- p.Ile122Val Single submitter ⚠
- p.Ile132Thr Single submitter ⚠
- p.Ile320Val Single submitter ⚠
- p.Ile41Met Single submitter ⚠
- p.Ile563Thr Single submitter ⚠
- p.Ile579Leu Single submitter ⚠
- p.Ile599Val Single submitter ⚠
- p.Leu102Arg Single submitter ⚠
- p.Leu110Phe Single submitter ⚠
- p.Leu119Pro Single submitter ⚠
- p.Leu293Val Single submitter ⚠
- p.Leu525Val Single submitter ⚠
- p.Lys378Glu Single submitter ⚠
- p.Met43Val Single submitter ⚠
- p.Met666Ile Single submitter ⚠
- p.Met666Val Single submitter ⚠
- p.Met92Val Single submitter ⚠
- p.Phe121Leu Single submitter ⚠
- p.Pro108Ala Single submitter ⚠
- p.Pro220Leu Single submitter ⚠
- p.Pro249Ser Single submitter ⚠
- p.Pro310Arg Single submitter ⚠
- p.Pro31Ala Single submitter ⚠
- p.Ser510Gly Single submitter ⚠
- p.Ser550Gly Single submitter ⚠
- p.Thr134Ser Single submitter ⚠
- p.Thr198Ile Single submitter ⚠
- p.Thr271Ala Single submitter ⚠
- p.Thr271Arg Single submitter ⚠
- p.Trp627Cys Single submitter ⚠
- p.Tyr306Cys Single submitter ⚠
- p.Tyr605Cys Single submitter ⚠
- p.Val231Ile Single submitter ⚠
- p.Val312Phe Single submitter ⚠
- p.Val470Ile Single submitter ⚠
- p.Val560Ile Single submitter ⚠