ARNT — 76 ClinVar variants
All ClinVar germline ARNT variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 73 flagged for review →
1 Benign/Likely benign · 2 Likely benign · 73 Uncertain significance
Full ARNT gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 73
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 51
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARNT p.Ala107Gly Uncertain significance Single submitter
- ARNT p.Ala20Pro Uncertain significance Single submitter
- ARNT p.Ala687Val Uncertain significance Single submitter
- ARNT p.Ala84Thr Uncertain significance Single submitter
- ARNT p.Arg235His Uncertain significance Single submitter
- ARNT p.Arg472Gln Uncertain significance Single submitter
- ARNT p.Arg481Lys Uncertain significance Single submitter
- ARNT p.Arg595Gln Uncertain significance Single submitter
- ARNT p.Arg700His Uncertain significance Single submitter
- ARNT p.Arg718Gln Uncertain significance Single submitter
- ARNT p.Asn395Ser Uncertain significance Single submitter
- ARNT p.Asn774Ser Uncertain significance Single submitter
- ARNT p.Asp216Val Uncertain significance Single submitter
- ARNT p.Cys256Arg Uncertain significance Single submitter
- ARNT p.Cys351Ser Uncertain significance Single submitter
- ARNT p.Gln582Lys Uncertain significance Single submitter
- ARNT p.Gln664His Uncertain significance Single submitter
- ARNT p.Gln769Glu Uncertain significance Single submitter
- ARNT p.Glu370Asp Uncertain significance Single submitter
- ARNT p.Glu390Val Uncertain significance Single submitter
- ARNT p.Gly294Ser Uncertain significance Single submitter
- ARNT p.Gly571Ala Uncertain significance Single submitter
- ARNT p.Gly646Ala Uncertain significance Single submitter
- ARNT p.Gly666Ala Uncertain significance Single submitter
- ARNT p.His562Tyr Uncertain significance Single submitter
- ARNT p.His735Asp Uncertain significance Single submitter
- ARNT p.Ile611Leu Uncertain significance Single submitter
- ARNT p.Leu225Phe Uncertain significance Single submitter
- ARNT p.Leu605Pro Uncertain significance Single submitter
- ARNT p.Lys465Gln Uncertain significance Single submitter
- ARNT p.Met255Lys Uncertain significance Single submitter
- ARNT p.Met494Ile Uncertain significance Single submitter
- ARNT p.Met679Thr Uncertain significance Single submitter
- ARNT p.Phe590Ile Uncertain significance Single submitter
- ARNT p.Pro19Thr Uncertain significance Single submitter
- ARNT p.Pro301Ser Uncertain significance Single submitter
- ARNT p.Pro388Ala Uncertain significance Single submitter
- ARNT p.Pro45Ser Uncertain significance Single submitter
- ARNT p.Pro486Ser Uncertain significance Single submitter
- ARNT p.Pro501Ser Uncertain significance Single submitter
- ARNT p.Pro748Leu Uncertain significance Single submitter
- ARNT p.Ser262Leu Uncertain significance Single submitter
- ARNT p.Ser688Leu Uncertain significance Single submitter
- ARNT p.Thr383Ala Uncertain significance Single submitter
- ARNT p.Thr460Ala Uncertain significance Single submitter
- ARNT p.Thr487Ala Uncertain significance Single submitter
- ARNT p.Thr593Asn Uncertain significance Single submitter
- ARNT p.Thr686Ala Uncertain significance Single submitter
- ARNT p.Trp315Arg Uncertain significance Single submitter
- ARNT p.Val213Met Uncertain significance Single submitter
- ARNT p.Val357Ala Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- ARNT p.Arg43Trp Uncertain significance Single submitter
- ARNT p.Asn563Asp Uncertain significance Single submitter
- ARNT p.Asp298His Uncertain significance Single submitter
- ARNT p.Asp325Gly Uncertain significance Single submitter
- ARNT p.Gln505Glu Uncertain significance Single submitter
- ARNT p.Gln582Glu Uncertain significance Single submitter
- ARNT p.Gln733Lys Uncertain significance Single submitter
- ARNT p.Gly724Asp Uncertain significance Single submitter
- ARNT p.Leu622Ser Uncertain significance Single submitter
- ARNT p.Lys86Arg Uncertain significance Single submitter
- ARNT p.Met354Val Uncertain significance Single submitter
- ARNT p.Phe74Cys Uncertain significance Single submitter
- ARNT p.Phe74Leu Uncertain significance Single submitter
- ARNT p.Pro594Arg Uncertain significance Single submitter
- ARNT p.Pro786Ala Uncertain significance Single submitter
- ARNT p.Ser180Leu Uncertain significance Single submitter
- ARNT p.Ser321Cys Uncertain significance Single submitter
- ARNT p.Ser603Gly Uncertain significance Single submitter
- ARNT p.Ser615Leu Uncertain significance Single submitter
- ARNT p.Ser77Leu Uncertain significance Single submitter
- ARNT p.Thr698Ile Uncertain significance Single submitter
- ARNT p.Val384Leu Uncertain significance Single submitter
All ARNT variants
Benign/Likely benign 1
- p.Asp511Asn Multiple submitters
Likely benign 2
- p.Gly330= Single submitter
- p.Ser271Asn Single submitter
Uncertain significance 73
- p.Ala107Gly Single submitter ⚠
- p.Ala20Pro Single submitter ⚠
- p.Ala687Val Single submitter ⚠
- p.Ala84Thr Single submitter ⚠
- p.Arg235His Single submitter ⚠
- p.Arg43Trp Single submitter ⚠
- p.Arg472Gln Single submitter ⚠
- p.Arg481Lys Single submitter ⚠
- p.Arg595Gln Single submitter ⚠
- p.Arg700His Single submitter ⚠
- p.Arg718Gln Single submitter ⚠
- p.Asn395Ser Single submitter ⚠
- p.Asn563Asp Single submitter ⚠
- p.Asn774Ser Single submitter ⚠
- p.Asp216Val Single submitter ⚠
- p.Asp298His Single submitter ⚠
- p.Asp325Gly Single submitter ⚠
- p.Cys256Arg Single submitter ⚠
- p.Cys351Ser Single submitter ⚠
- p.Gln505Glu Single submitter ⚠
- p.Gln582Glu Single submitter ⚠
- p.Gln582Lys Single submitter ⚠
- p.Gln664His Single submitter ⚠
- p.Gln733Lys Single submitter ⚠
- p.Gln769Glu Single submitter ⚠
- p.Glu370Asp Single submitter ⚠
- p.Glu390Val Single submitter ⚠
- p.Gly294Ser Single submitter ⚠
- p.Gly571Ala Single submitter ⚠
- p.Gly646Ala Single submitter ⚠
- p.Gly666Ala Single submitter ⚠
- p.Gly724Asp Single submitter ⚠
- p.His562Tyr Single submitter ⚠
- p.His735Asp Single submitter ⚠
- p.Ile611Leu Single submitter ⚠
- p.Leu225Phe Single submitter ⚠
- p.Leu605Pro Single submitter ⚠
- p.Leu622Ser Single submitter ⚠
- p.Lys465Gln Single submitter ⚠
- p.Lys86Arg Single submitter ⚠
- p.Met255Lys Single submitter ⚠
- p.Met354Val Single submitter ⚠
- p.Met494Ile Single submitter ⚠
- p.Met679Thr Single submitter ⚠
- p.Phe590Ile Single submitter ⚠
- p.Phe74Cys Single submitter ⚠
- p.Phe74Leu Single submitter ⚠
- p.Pro19Thr Single submitter ⚠
- p.Pro301Ser Single submitter ⚠
- p.Pro388Ala Single submitter ⚠
- p.Pro45Ser Single submitter ⚠
- p.Pro486Ser Single submitter ⚠
- p.Pro501Ser Single submitter ⚠
- p.Pro594Arg Single submitter ⚠
- p.Pro748Leu Single submitter ⚠
- p.Pro786Ala Single submitter ⚠
- p.Ser180Leu Single submitter ⚠
- p.Ser262Leu Single submitter ⚠
- p.Ser321Cys Single submitter ⚠
- p.Ser603Gly Single submitter ⚠
- p.Ser615Leu Single submitter ⚠
- p.Ser688Leu Single submitter ⚠
- p.Ser77Leu Single submitter ⚠
- p.Thr383Ala Single submitter ⚠
- p.Thr460Ala Single submitter ⚠
- p.Thr487Ala Single submitter ⚠
- p.Thr593Asn Single submitter ⚠
- p.Thr686Ala Single submitter ⚠
- p.Thr698Ile Single submitter ⚠
- p.Trp315Arg Single submitter ⚠
- p.Val213Met Single submitter ⚠
- p.Val357Ala Single submitter ⚠
- p.Val384Leu Single submitter ⚠