ARPC1A — 42 ClinVar variants
All ClinVar germline ARPC1A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
1 Likely benign · 41 Uncertain significance
Full ARPC1A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARPC1A p.Ala220Gly Uncertain significance Single submitter
- ARPC1A p.Ala45Val Uncertain significance Single submitter
- ARPC1A p.Arg142His Uncertain significance Single submitter
- ARPC1A p.Arg277Cys Uncertain significance Single submitter
- ARPC1A p.Arg277Gly Uncertain significance Single submitter
- ARPC1A p.Arg277His Uncertain significance Single submitter
- ARPC1A p.Arg302His Uncertain significance Single submitter
- ARPC1A p.Arg341His Uncertain significance Single submitter
- ARPC1A p.Arg368Trp Uncertain significance Single submitter
- ARPC1A p.Asn296Ser Uncertain significance Single submitter
- ARPC1A p.Asn305Ser Uncertain significance Single submitter
- ARPC1A p.Asn316Ser Uncertain significance Single submitter
- ARPC1A p.Asp65Asn Uncertain significance Single submitter
- ARPC1A p.Gly202Ser Uncertain significance Single submitter
- ARPC1A p.Gly39Arg Uncertain significance Single submitter
- ARPC1A p.Gly84Ser Uncertain significance Single submitter
- ARPC1A p.His46Tyr Uncertain significance Single submitter
- ARPC1A p.Ile354Val Uncertain significance Single submitter
- ARPC1A p.Leu194Pro Uncertain significance Single submitter
- ARPC1A p.Leu3Val Uncertain significance Single submitter
- ARPC1A p.Lys103Thr Uncertain significance Single submitter
- ARPC1A p.Met352Leu Uncertain significance Single submitter
- ARPC1A p.Ser147Gly Uncertain significance Single submitter
- ARPC1A p.Ser251Cys Uncertain significance Single submitter
- ARPC1A p.Ser80Arg Uncertain significance Single submitter
- ARPC1A p.Tyr77Cys Uncertain significance Single submitter
- ARPC1A p.Val261Met Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- ARPC1A p.Arg218His Uncertain significance Single submitter
- ARPC1A p.Arg368Gln Uncertain significance Single submitter
- ARPC1A p.Asn258Asp Uncertain significance Single submitter
- ARPC1A p.Ile67Val Uncertain significance Single submitter
- ARPC1A p.Leu3Pro Uncertain significance Single submitter
- ARPC1A p.Met270Ile Uncertain significance Single submitter
- ARPC1A p.Ser215Gly Uncertain significance Single submitter
- ARPC1A p.Ser363Phe Uncertain significance Single submitter
All ARPC1A variants
Likely benign 1
- p.Thr21= Single submitter
Uncertain significance 41
- p.Ala220Gly Single submitter ⚠
- p.Ala45Val Single submitter ⚠
- p.Arg142His Single submitter ⚠
- p.Arg218His Single submitter ⚠
- p.Arg277Cys Single submitter ⚠
- p.Arg277Gly Single submitter ⚠
- p.Arg277His Single submitter ⚠
- p.Arg302His Single submitter ⚠
- p.Arg341His Single submitter ⚠
- p.Arg368Gln Single submitter ⚠
- p.Arg368Trp Single submitter ⚠
- p.Asn154Ser Single submitter
- p.Asn17Ser Single submitter
- p.Asn258Asp Single submitter ⚠
- p.Asn296Ser Single submitter ⚠
- p.Asn305Ser Single submitter ⚠
- p.Asn316Ser Single submitter ⚠
- p.Asp65Asn Single submitter ⚠
- p.Gln291Pro Single submitter
- p.Gly200Val Single submitter
- p.Gly202Ser Single submitter ⚠
- p.Gly39Arg Single submitter ⚠
- p.Gly84Ser Single submitter ⚠
- p.His46Tyr Single submitter ⚠
- p.His54Arg Single submitter
- p.Ile354Val Single submitter ⚠
- p.Ile67Val Single submitter ⚠
- p.Leu194Pro Single submitter ⚠
- p.Leu3Pro Single submitter ⚠
- p.Leu3Val Single submitter ⚠
- p.Lys103Thr Single submitter ⚠
- p.Met270Ile Single submitter ⚠
- p.Met352Leu Single submitter ⚠
- p.Ser147Gly Single submitter ⚠
- p.Ser215Gly Single submitter ⚠
- p.Ser251Cys Single submitter ⚠
- p.Ser363Phe Single submitter ⚠
- p.Ser80Arg Single submitter ⚠
- p.Tyr77Cys Single submitter ⚠
- p.Val228Met Single submitter
- p.Val261Met Single submitter ⚠