ARPP21 — 104 ClinVar variants
All ClinVar germline ARPP21 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 92 flagged for review →
1 Likely pathogenic · 5 Likely benign · 98 Uncertain significance
Full ARPP21 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 92
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 79
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARPP21 p.Ala12Thr Uncertain significance Single submitter
- ARPP21 p.Ala179Thr Uncertain significance Single submitter
- ARPP21 p.Ala440Thr Uncertain significance Single submitter
- ARPP21 p.Ala498Val Uncertain significance Single submitter
- ARPP21 p.Ala708Gly Uncertain significance Single submitter
- ARPP21 p.Ala712Thr Uncertain significance Single submitter
- ARPP21 p.Ala829Val Uncertain significance Single submitter
- ARPP21 p.Arg107Lys Uncertain significance Single submitter
- ARPP21 p.Arg313Lys Uncertain significance Single submitter
- ARPP21 p.Arg332Trp Uncertain significance Single submitter
- ARPP21 p.Arg372Cys Uncertain significance Single submitter
- ARPP21 p.Arg44Ser Uncertain significance Single submitter
- ARPP21 p.Arg832Lys Uncertain significance Single submitter
- ARPP21 p.Asn322Ser Uncertain significance Single submitter
- ARPP21 p.Asn451Lys Uncertain significance Single submitter
- ARPP21 p.Asn802Asp Uncertain significance Single submitter
- ARPP21 p.Asp209Asn Uncertain significance Single submitter
- ARPP21 p.Asp240Ala Uncertain significance Single submitter
- ARPP21 p.Asp35Tyr Uncertain significance Single submitter
- ARPP21 p.Cys235Ser Uncertain significance Single submitter
- ARPP21 p.Gln518Leu Uncertain significance Single submitter
- ARPP21 p.Gln665His Uncertain significance Single submitter
- ARPP21 p.Gln744Lys Uncertain significance Single submitter
- ARPP21 p.Glu450Asp Uncertain significance Single submitter
- ARPP21 p.Gly27Ser Uncertain significance Single submitter
- ARPP21 p.Gly337Arg Uncertain significance Single submitter
- ARPP21 p.Gly543Asp Uncertain significance Single submitter
- ARPP21 p.Gly543Ser Uncertain significance Single submitter
- ARPP21 p.Gly679Cys Uncertain significance Single submitter
- ARPP21 p.Gly816Asp Uncertain significance Single submitter
- ARPP21 p.Gly81Val Uncertain significance Single submitter
- ARPP21 p.His91Asp Uncertain significance Single submitter
- ARPP21 p.Ile648Val Uncertain significance Single submitter
- ARPP21 p.Ile90Thr Uncertain significance Single submitter
- ARPP21 p.Leu100Arg Uncertain significance Single submitter
- ARPP21 p.Leu34Met Uncertain significance Single submitter
- ARPP21 p.Leu466Ile Uncertain significance Single submitter
- ARPP21 p.Leu481Arg Uncertain significance Single submitter
- ARPP21 p.Leu65Pro Uncertain significance Single submitter
- ARPP21 p.Leu718Phe Uncertain significance Single submitter
- ARPP21 p.Leu94Ile Uncertain significance Single submitter
- ARPP21 p.Lys253Gln Uncertain significance Single submitter
- ARPP21 p.Met269Ile Uncertain significance Single submitter
- ARPP21 p.Met378Ile Uncertain significance Single submitter
- ARPP21 p.Met705Leu Uncertain significance Single submitter
- ARPP21 p.Met797Ile Uncertain significance Single submitter
- ARPP21 p.Phe206Leu Uncertain significance Single submitter
- ARPP21 p.Phe308Ser Uncertain significance Single submitter
- ARPP21 p.Pro433Leu Uncertain significance Single submitter
- ARPP21 p.Pro433Thr Uncertain significance Single submitter
- ARPP21 p.Pro443Ala Uncertain significance Single submitter
- ARPP21 p.Pro447Arg Uncertain significance Single submitter
- ARPP21 p.Pro544Thr Uncertain significance Single submitter
- ARPP21 p.Pro667Leu Uncertain significance Single submitter
- ARPP21 p.Pro672Ala Uncertain significance Single submitter
- ARPP21 p.Pro691Ala Uncertain significance Single submitter
- ARPP21 p.Pro716Thr Uncertain significance Single submitter
- ARPP21 p.Ser342Thr Uncertain significance Single submitter
- ARPP21 p.Ser347Gly Uncertain significance Single submitter
- ARPP21 p.Ser442Pro Uncertain significance Single submitter
- ARPP21 p.Ser702Cys Uncertain significance Single submitter
- ARPP21 p.Ser839Arg Uncertain significance Single submitter
- ARPP21 p.Thr224Asn Uncertain significance Single submitter
- ARPP21 p.Thr396Ala Uncertain significance Single submitter
- ARPP21 p.Thr399Ala Uncertain significance Single submitter
- ARPP21 p.Thr432Pro Uncertain significance Single submitter
- ARPP21 p.Thr473Ala Uncertain significance Single submitter
- ARPP21 p.Thr589Ile Uncertain significance Single submitter
- ARPP21 p.Thr632Ile Uncertain significance Single submitter
- ARPP21 p.Thr757Ala Uncertain significance Single submitter
- ARPP21 p.Thr807Ala Uncertain significance Single submitter
- ARPP21 p.Tyr464His Uncertain significance Single submitter
- ARPP21 p.Tyr755Cys Uncertain significance Single submitter
- ARPP21 p.Val491Ala Uncertain significance Single submitter
- ARPP21 p.Val587Met Uncertain significance Single submitter
- ARPP21 p.Val751Met Uncertain significance Single submitter
- ARPP21 p.Val753Phe Uncertain significance Single submitter
-
ARPP21 p.Gln775His
Uncertain significance
No assertion criteria
monomelic amyotrophy
-
ARPP21 p.Gly452Val
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 13
The independent predictors disagree with each other — read with care.
- ARPP21 p.Arg372Ser Uncertain significance Single submitter
- ARPP21 p.Asn802Lys Uncertain significance Single submitter
- ARPP21 p.Asp299Val Uncertain significance Single submitter
- ARPP21 p.Gln524Glu Uncertain significance Single submitter
- ARPP21 p.Gln696Lys Uncertain significance Single submitter
- ARPP21 p.Gly343Glu Uncertain significance Single submitter
- ARPP21 p.Gly417Asp Uncertain significance Single submitter
- ARPP21 p.Gly420Arg Uncertain significance Single submitter
- ARPP21 p.Ile499Thr Uncertain significance Single submitter
- ARPP21 p.Lys279Gln Uncertain significance Single submitter
- ARPP21 p.Ser306Arg Uncertain significance Single submitter
- ARPP21 p.Val291Met Uncertain significance Single submitter
- ARPP21 p.Val389Ala Uncertain significance Single submitter
All ARPP21 variants
Likely pathogenic 1
- p.Pro563Leu Single submitter
Likely benign 5
- p.Ala630Thr Single submitter
- p.Arg249= Single submitter
- p.Ile453Met Single submitter
- p.Leu330= Single submitter
- p.Ser566= Single submitter
Uncertain significance 98
- p.Ala12Thr Single submitter ⚠
- p.Ala179Thr Single submitter ⚠
- p.Ala440Thr Single submitter ⚠
- p.Ala498Val Single submitter ⚠
- p.Ala708Gly Single submitter ⚠
- p.Ala712Thr Single submitter ⚠
- p.Ala829Val Single submitter ⚠
- p.Arg107Lys Single submitter ⚠
- p.Arg313Lys Single submitter ⚠
- p.Arg332Trp Single submitter ⚠
- p.Arg372Cys Single submitter ⚠
- p.Arg372Ser Single submitter ⚠
- p.Arg44Ser Single submitter ⚠
- p.Arg598Trp Single submitter
- p.Arg813Thr Single submitter
- p.Arg832Lys Single submitter ⚠
- p.Asn222Ser Single submitter
- p.Asn322Ser Single submitter ⚠
- p.Asn451Lys Single submitter ⚠
- p.Asn802Asp Single submitter ⚠
- p.Asn802Lys Single submitter ⚠
- p.Asp209Asn Single submitter ⚠
- p.Asp240Ala Single submitter ⚠
- p.Asp299Val Single submitter ⚠
- p.Asp35Tyr Single submitter ⚠
- p.Cys235Ser Single submitter ⚠
- p.Gln518Leu Single submitter ⚠
- p.Gln524Glu Single submitter ⚠
- p.Gln665His Single submitter ⚠
- p.Gln696Lys Single submitter ⚠
- p.Gln744Lys Single submitter ⚠
- p.Glu450Asp Single submitter ⚠
- p.Gly27Ser Single submitter ⚠
- p.Gly337Arg Single submitter ⚠
- p.Gly343Glu Single submitter ⚠
- p.Gly417Asp Single submitter ⚠
- p.Gly420Arg Single submitter ⚠
- p.Gly543Asp Single submitter ⚠
- p.Gly543Ser Single submitter ⚠
- p.Gly640Arg Single submitter
- p.Gly679Cys Single submitter ⚠
- p.Gly816Asp Single submitter ⚠
- p.Gly81Val Single submitter ⚠
- p.His91Asp Single submitter ⚠
- p.Ile499Thr Single submitter ⚠
- p.Ile648Val Single submitter ⚠
- p.Ile90Thr Single submitter ⚠
- p.Leu100Arg Single submitter ⚠
- p.Leu34Met Single submitter ⚠
- p.Leu466Ile Single submitter ⚠
- p.Leu481Arg Single submitter ⚠
- p.Leu65Pro Single submitter ⚠
- p.Leu718Phe Single submitter ⚠
- p.Leu94Ile Single submitter ⚠
- p.Lys253Gln Single submitter ⚠
- p.Lys279Gln Single submitter ⚠
- p.Met269Ile Single submitter ⚠
- p.Met378Ile Single submitter ⚠
- p.Met705Leu Single submitter ⚠
- p.Met797Ile Single submitter ⚠
- p.Phe206Leu Single submitter ⚠
- p.Phe308Ser Single submitter ⚠
- p.Pro433Leu Single submitter ⚠
- p.Pro433Thr Single submitter ⚠
- p.Pro443Ala Single submitter ⚠
- p.Pro447Arg Single submitter ⚠
- p.Pro502Leu Single submitter
- p.Pro544Thr Single submitter ⚠
- p.Pro667Leu Single submitter ⚠
- p.Pro672Ala Single submitter ⚠
- p.Pro691Ala Single submitter ⚠
- p.Pro716Thr Single submitter ⚠
- p.Ser306Arg Single submitter ⚠
- p.Ser342Thr Single submitter ⚠
- p.Ser347Gly Single submitter ⚠
- p.Ser442Pro Single submitter ⚠
- p.Ser702Cys Single submitter ⚠
- p.Ser839Arg Single submitter ⚠
- p.Thr224Asn Single submitter ⚠
- p.Thr396Ala Single submitter ⚠
- p.Thr399Ala Single submitter ⚠
- p.Thr432Pro Single submitter ⚠
- p.Thr473Ala Single submitter ⚠
- p.Thr589Ile Single submitter ⚠
- p.Thr632Ile Single submitter ⚠
- p.Thr757Ala Single submitter ⚠
- p.Thr807Ala Single submitter ⚠
- p.Tyr464His Single submitter ⚠
- p.Tyr755Cys Single submitter ⚠
- p.Val291Met Single submitter ⚠
- p.Val389Ala Single submitter ⚠
- p.Val491Ala Single submitter ⚠
- p.Val587Met Single submitter ⚠
- p.Val751Met Single submitter ⚠
- p.Val753Phe Single submitter ⚠
- p.Val845Gly Single submitter
- p.Gln775His No assertion criteria monomelic amyotrophy ⚠
- p.Gly452Val No assertion criteria prostate cancer ⚠