ARRB1 — 46 ClinVar variants
All ClinVar germline ARRB1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
3 Likely benign · 43 Uncertain significance
Full ARRB1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARRB1 p.Ala82Ser Uncertain significance Single submitter
- ARRB1 p.Ala82Thr Uncertain significance Single submitter
- ARRB1 p.Arg177Ser Uncertain significance Single submitter
- ARRB1 p.Arg363Gln Uncertain significance Single submitter
- ARRB1 p.Arg418Gly Uncertain significance Single submitter
- ARRB1 p.Arg51Trp Uncertain significance Single submitter
- ARRB1 p.Arg62Cys Uncertain significance Single submitter
- ARRB1 p.Asn299Lys Uncertain significance Single submitter
- ARRB1 p.Asn311Ser Uncertain significance Single submitter
- ARRB1 p.Gly109Ser Uncertain significance Single submitter
- ARRB1 p.Gly2Asp Uncertain significance Single submitter
- ARRB1 p.Ile105Met Uncertain significance Single submitter
- ARRB1 p.Ile241Thr Uncertain significance Single submitter
- ARRB1 p.Leu129Arg Uncertain significance Single submitter
- ARRB1 p.Leu154Ser Uncertain significance Single submitter
- ARRB1 p.Leu33His Uncertain significance Single submitter
- ARRB1 p.Pro120Ser Uncertain significance Single submitter
- ARRB1 p.Pro131Leu Uncertain significance Single submitter
- ARRB1 p.Pro360Ala Uncertain significance Single submitter
- ARRB1 p.Pro88Leu Uncertain significance Single submitter
- ARRB1 p.Ser86Leu Uncertain significance Single submitter
- ARRB1 p.Thr370Ser Uncertain significance Single submitter
- ARRB1 p.Thr98Lys Uncertain significance Single submitter
- ARRB1 p.Val216Ile Uncertain significance Single submitter
- ARRB1 p.Val235Ala Uncertain significance Single submitter
- ARRB1 p.Val41Ile Uncertain significance Single submitter
- ARRB1 p.Val41Phe Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- ARRB1 p.Ala151Thr Uncertain significance Single submitter
- ARRB1 p.Ala263Thr Uncertain significance Single submitter
- ARRB1 p.Arg282Gln Uncertain significance Single submitter
- ARRB1 p.Arg312Cys Uncertain significance Single submitter
- ARRB1 p.Arg51Gln Uncertain significance Single submitter
- ARRB1 p.Arg99Trp Uncertain significance Single submitter
- ARRB1 p.Asn122Lys Uncertain significance Single submitter
- ARRB1 p.Gly333Ser Uncertain significance Single submitter
- ARRB1 p.Ile233Thr Uncertain significance Single submitter
- ARRB1 p.Pro96Ala Uncertain significance Single submitter
- ARRB1 p.Thr227Met Uncertain significance Single submitter
- ARRB1 p.Val167Phe Uncertain significance Single submitter
- ARRB1 p.Val218Ile Uncertain significance Single submitter
- ARRB1 p.Val329Leu Uncertain significance Single submitter
- ARRB1 p.Val343Met Uncertain significance Single submitter
All ARRB1 variants
Likely benign 3
- p.Glu369Gln Single submitter
- p.Pro361Leu Single submitter
- p.Ser341= Single submitter
Uncertain significance 43
- p.Ala151Thr Single submitter ⚠
- p.Ala263Thr Single submitter ⚠
- p.Ala82Ser Single submitter ⚠
- p.Ala82Thr Single submitter ⚠
- p.Arg177Ser Single submitter ⚠
- p.Arg282Gln Single submitter ⚠
- p.Arg312Cys Single submitter ⚠
- p.Arg363Gln Single submitter ⚠
- p.Arg418Gly Single submitter ⚠
- p.Arg51Gln Single submitter ⚠
- p.Arg51Trp Single submitter ⚠
- p.Arg62Cys Single submitter ⚠
- p.Arg99Trp Single submitter ⚠
- p.Asn122Lys Single submitter ⚠
- p.Asn299Lys Single submitter ⚠
- p.Asn311Ser Single submitter ⚠
- p.Gln181Ter Single submitter
- p.Gly109Ser Single submitter ⚠
- p.Gly2Asp Single submitter ⚠
- p.Gly333Ser Single submitter ⚠
- p.Ile105Met Single submitter ⚠
- p.Ile233Thr Single submitter ⚠
- p.Ile241Thr Single submitter ⚠
- p.Leu129Arg Single submitter ⚠
- p.Leu154Ser Single submitter ⚠
- p.Leu33His Single submitter ⚠
- p.Pro120Ser Single submitter ⚠
- p.Pro131Leu Single submitter ⚠
- p.Pro360Ala Single submitter ⚠
- p.Pro88Leu Single submitter ⚠
- p.Pro96Ala Single submitter ⚠
- p.Ser86Leu Single submitter ⚠
- p.Thr227Met Single submitter ⚠
- p.Thr370Ser Single submitter ⚠
- p.Thr98Lys Single submitter ⚠
- p.Val167Phe Single submitter ⚠
- p.Val216Ile Single submitter ⚠
- p.Val218Ile Single submitter ⚠
- p.Val235Ala Single submitter ⚠
- p.Val329Leu Single submitter ⚠
- p.Val343Met Single submitter ⚠
- p.Val41Ile Single submitter ⚠
- p.Val41Phe Single submitter ⚠