ARRDC4 — 70 ClinVar variants
All ClinVar germline ARRDC4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 62 flagged for review →
3 Benign · 2 Likely benign · 65 Uncertain significance
Full ARRDC4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 62
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 53
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARRDC4 p.Ala211Thr Uncertain significance Single submitter
- ARRDC4 p.Ala252Thr Uncertain significance Single submitter
- ARRDC4 p.Ala294Ser Uncertain significance Single submitter
- ARRDC4 p.Ala9Thr Uncertain significance Single submitter
- ARRDC4 p.Arg119Cys Uncertain significance Single submitter
- ARRDC4 p.Arg158Gln Uncertain significance Single submitter
- ARRDC4 p.Arg224His Uncertain significance Single submitter
- ARRDC4 p.Arg248Gln Uncertain significance Single submitter
- ARRDC4 p.Arg391Gly Uncertain significance Single submitter
- ARRDC4 p.Arg74Cys Uncertain significance Single submitter
- ARRDC4 p.Asn253Ser Uncertain significance Single submitter
- ARRDC4 p.Asn268Asp Uncertain significance Single submitter
- ARRDC4 p.Asp153Glu Uncertain significance Single submitter
- ARRDC4 p.Asp167Asn Uncertain significance Single submitter
- ARRDC4 p.Asp167Val Uncertain significance Single submitter
- ARRDC4 p.Asp265His Uncertain significance Single submitter
- ARRDC4 p.Cys285Arg Uncertain significance Single submitter
- ARRDC4 p.Cys381Arg Uncertain significance Single submitter
- ARRDC4 p.Cys72Arg Uncertain significance Single submitter
- ARRDC4 p.Glu147Lys Uncertain significance Single submitter
- ARRDC4 p.Glu14Lys Uncertain significance Single submitter
- ARRDC4 p.Glu360Gln Uncertain significance Single submitter
- ARRDC4 p.Glu378Asp Uncertain significance Single submitter
- ARRDC4 p.Glu389Lys Uncertain significance Single submitter
- ARRDC4 p.Glu89Gln Uncertain significance Single submitter
- ARRDC4 p.Glu99Gly Uncertain significance Single submitter
- ARRDC4 p.Gly12Cys Uncertain significance Single submitter
- ARRDC4 p.Gly269Arg Uncertain significance Single submitter
- ARRDC4 p.Gly61Glu Uncertain significance Single submitter
- ARRDC4 p.His404Leu Uncertain significance Single submitter
- ARRDC4 p.Ile107Ser Uncertain significance Single submitter
- ARRDC4 p.Ile107Thr Uncertain significance Single submitter
- ARRDC4 p.Ile212Thr Uncertain significance Single submitter
- ARRDC4 p.Ile247Thr Uncertain significance Single submitter
- ARRDC4 p.Ile259Val Uncertain significance Single submitter
- ARRDC4 p.Ile328Thr Uncertain significance Single submitter
- ARRDC4 p.Leu57Gln Uncertain significance Single submitter
- ARRDC4 p.Met250Val Uncertain significance Single submitter
- ARRDC4 p.Pro176Ala Uncertain significance Single submitter
- ARRDC4 p.Pro370Leu Uncertain significance Single submitter
- ARRDC4 p.Pro372Leu Uncertain significance Single submitter
- ARRDC4 p.Pro413Ser Uncertain significance Single submitter
- ARRDC4 p.Ser164Cys Uncertain significance Single submitter
- ARRDC4 p.Ser333Thr Uncertain significance Single submitter
- ARRDC4 p.Ser76Leu Uncertain significance Single submitter
- ARRDC4 p.Ser78Asn Uncertain significance Single submitter
- ARRDC4 p.Thr246Asn Uncertain significance Single submitter
- ARRDC4 p.Tyr318Cys Uncertain significance Single submitter
- ARRDC4 p.Val142Met Uncertain significance Single submitter
- ARRDC4 p.Val151Ile Uncertain significance Single submitter
- ARRDC4 p.Val23Met Uncertain significance Single submitter
- ARRDC4 p.Val408Gly Uncertain significance Single submitter
-
ARRDC4 p.Glu182Gln
Uncertain significance
No assertion criteria
ARRDC4-related condition
Predictors split 9
The independent predictors disagree with each other — read with care.
- ARRDC4 p.Arg143Trp Uncertain significance Single submitter
- ARRDC4 p.Arg98Pro Uncertain significance Single submitter
- ARRDC4 p.Asp153Tyr Uncertain significance Single submitter
- ARRDC4 p.Gly21Arg Uncertain significance Single submitter
- ARRDC4 p.Gly262Glu Uncertain significance Single submitter
- ARRDC4 p.Leu52Arg Uncertain significance Single submitter
- ARRDC4 p.Pro49Leu Uncertain significance Single submitter
- ARRDC4 p.Thr340Ile Uncertain significance Single submitter
- ARRDC4 p.Trp188Cys Uncertain significance Single submitter
All ARRDC4 variants
Benign 3
- p.Ala77= Multiple submitters
- p.Thr79Ala Multiple submitters
- p.Gln139His Single submitter
Likely benign 2
- c.883-5A>T Single submitter
- p.Ser78Gly Single submitter
Uncertain significance 65
- p.Ala211Thr Single submitter ⚠
- p.Ala252Thr Single submitter ⚠
- p.Ala294Ser Single submitter ⚠
- p.Ala9Thr Single submitter ⚠
- p.Arg119Cys Single submitter ⚠
- p.Arg143Trp Single submitter ⚠
- p.Arg158Gln Single submitter ⚠
- p.Arg224His Single submitter ⚠
- p.Arg248Gln Single submitter ⚠
- p.Arg391Gly Single submitter ⚠
- p.Arg74Cys Single submitter ⚠
- p.Arg98Pro Single submitter ⚠
- p.Asn253Ser Single submitter ⚠
- p.Asn268Asp Single submitter ⚠
- p.Asp153Glu Single submitter ⚠
- p.Asp153Tyr Single submitter ⚠
- p.Asp167Asn Single submitter ⚠
- p.Asp167Val Single submitter ⚠
- p.Asp265His Single submitter ⚠
- p.Cys285Arg Single submitter ⚠
- p.Cys381Arg Single submitter ⚠
- p.Cys72Arg Single submitter ⚠
- p.Glu147Lys Single submitter ⚠
- p.Glu14Lys Single submitter ⚠
- p.Glu360Gln Single submitter ⚠
- p.Glu378Asp Single submitter ⚠
- p.Glu389Lys Single submitter ⚠
- p.Glu89Gln Single submitter ⚠
- p.Glu99Gly Single submitter ⚠
- p.Gly12Cys Single submitter ⚠
- p.Gly21Arg Single submitter ⚠
- p.Gly262Glu Single submitter ⚠
- p.Gly269Arg Single submitter ⚠
- p.Gly61Glu Single submitter ⚠
- p.His404Leu Single submitter ⚠
- p.Ile107Ser Single submitter ⚠
- p.Ile107Thr Single submitter ⚠
- p.Ile212Thr Single submitter ⚠
- p.Ile247Thr Single submitter ⚠
- p.Ile259Val Single submitter ⚠
- p.Ile328Thr Single submitter ⚠
- p.Leu52Arg Single submitter ⚠
- p.Leu57Gln Single submitter ⚠
- p.Met250Val Single submitter ⚠
- p.Pro176Ala Single submitter ⚠
- p.Pro370Leu Single submitter ⚠
- p.Pro372Leu Single submitter ⚠
- p.Pro413Ser Single submitter ⚠
- p.Pro49Leu Single submitter ⚠
- p.Ser164Cys Single submitter ⚠
- p.Ser333Thr Single submitter ⚠
- p.Ser76Leu Single submitter ⚠
- p.Ser78Asn Single submitter ⚠
- p.Thr129Pro Single submitter
- p.Thr246Asn Single submitter ⚠
- p.Thr340Ile Single submitter ⚠
- p.Trp188Cys Single submitter ⚠
- p.Trp67Ser Single submitter
- p.Tyr318Cys Single submitter ⚠
- p.Tyr32Cys Single submitter
- p.Val142Met Single submitter ⚠
- p.Val151Ile Single submitter ⚠
- p.Val23Met Single submitter ⚠
- p.Val408Gly Single submitter ⚠
- p.Glu182Gln No assertion criteria ARRDC4-related condition ⚠