ART3 — 70 ClinVar variants
All ClinVar germline ART3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 67 flagged for review →
3 Likely benign · 67 Uncertain significance
Full ART3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 67
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ART3 p.Ala14Ser Uncertain significance Single submitter
- ART3 p.Ala155Thr Uncertain significance Single submitter
- ART3 p.Ala193Gly Uncertain significance Single submitter
- ART3 p.Ala193Thr Uncertain significance Single submitter
- ART3 p.Ala388Asp Uncertain significance Single submitter
- ART3 p.Asn344Asp Uncertain significance Single submitter
- ART3 p.Asn344Ser Uncertain significance Single submitter
- ART3 p.Gln134His Uncertain significance Single submitter
- ART3 p.Gln370Glu Uncertain significance Single submitter
- ART3 p.Glu7Ala Uncertain significance Single submitter
- ART3 p.Gly174Glu Uncertain significance Single submitter
- ART3 p.Gly324Glu Uncertain significance Single submitter
- ART3 p.His113Arg Uncertain significance Single submitter
- ART3 p.His5Tyr Uncertain significance Single submitter
- ART3 p.Leu198Arg Uncertain significance Single submitter
- ART3 p.Leu227Met Uncertain significance Single submitter
- ART3 p.Leu242Phe Uncertain significance Single submitter
- ART3 p.Leu385Phe Uncertain significance Single submitter
- ART3 p.Leu55Met Uncertain significance Single submitter
- ART3 p.Leu86Ile Uncertain significance Single submitter
- ART3 p.Lys42Asn Uncertain significance Single submitter
- ART3 p.Phe133Leu Uncertain significance Single submitter
- ART3 p.Phe140Tyr Uncertain significance Single submitter
- ART3 p.Phe6Leu Uncertain significance Single submitter
- ART3 p.Ser156Gly Uncertain significance Single submitter
- ART3 p.Ser62Arg Uncertain significance Single submitter
- ART3 p.Thr320Ser Uncertain significance Single submitter
- ART3 p.Thr3Met Uncertain significance Single submitter
- ART3 p.Trp77Arg Uncertain significance Single submitter
- ART3 p.Val19Leu Uncertain significance Single submitter
- ART3 p.Val279Ala Uncertain significance Single submitter
- ART3 p.Val350Ala Uncertain significance Single submitter
- ART3 p.Val52Ile Uncertain significance Single submitter
Predictors split 34
The independent predictors disagree with each other — read with care.
- ART3 p.Ala118Val Uncertain significance Single submitter
- ART3 p.Ala382Asp Uncertain significance Single submitter
- ART3 p.Arg46Gly Uncertain significance Single submitter
- ART3 p.Asp210Tyr Uncertain significance Single submitter
- ART3 p.Asp291Gly Uncertain significance Single submitter
- ART3 p.Asp291Val Uncertain significance Single submitter
- ART3 p.Asp301Glu Uncertain significance Single submitter
- ART3 p.Asp311Glu Uncertain significance Single submitter
- ART3 p.Gln307Arg Uncertain significance Single submitter
- ART3 p.Gln83Pro Uncertain significance Single submitter
- ART3 p.Glu107Gly Uncertain significance Single submitter
- ART3 p.Glu300Gln Uncertain significance Single submitter
- ART3 p.Glu300Lys Uncertain significance Single submitter
- ART3 p.Gly283Ala Uncertain significance Single submitter
- ART3 p.Gly303Asp Uncertain significance Single submitter
- ART3 p.Ile222Ser Uncertain significance Single submitter
- ART3 p.Ile322Met Uncertain significance Single submitter
- ART3 p.Ile8Thr Uncertain significance Single submitter
- ART3 p.Leu299Phe Uncertain significance Single submitter
- ART3 p.Lys190Asn Uncertain significance Single submitter
- ART3 p.Lys263Glu Uncertain significance Single submitter
- ART3 p.Met99Lys Uncertain significance Single submitter
- ART3 p.Phe111Tyr Uncertain significance Single submitter
- ART3 p.Phe138Leu Uncertain significance Single submitter
- ART3 p.Phe258Ser Uncertain significance Single submitter
- ART3 p.Pro152Thr Uncertain significance Single submitter
- ART3 p.Pro351Ala Uncertain significance Single submitter
- ART3 p.Pro351Leu Uncertain significance Single submitter
- ART3 p.Ser103Cys Uncertain significance Single submitter
- ART3 p.Thr205Pro Uncertain significance Single submitter
- ART3 p.Tyr101Cys Uncertain significance Single submitter
- ART3 p.Tyr187Cys Uncertain significance Single submitter
- ART3 p.Val200Met Uncertain significance Single submitter
- ART3 p.Val350Phe Uncertain significance Single submitter
All ART3 variants
Likely benign 3
- p.Ala238Thr Single submitter
- p.Ile102Val Single submitter
- p.Ser103= Single submitter
Uncertain significance 67
- p.Ala118Val Single submitter ⚠
- p.Ala14Ser Single submitter ⚠
- p.Ala155Thr Single submitter ⚠
- p.Ala193Gly Single submitter ⚠
- p.Ala193Thr Single submitter ⚠
- p.Ala382Asp Single submitter ⚠
- p.Ala388Asp Single submitter ⚠
- p.Arg46Gly Single submitter ⚠
- p.Asn344Asp Single submitter ⚠
- p.Asn344Ser Single submitter ⚠
- p.Asp210Tyr Single submitter ⚠
- p.Asp291Gly Single submitter ⚠
- p.Asp291Val Single submitter ⚠
- p.Asp301Glu Single submitter ⚠
- p.Asp311Glu Single submitter ⚠
- p.Gln134His Single submitter ⚠
- p.Gln307Arg Single submitter ⚠
- p.Gln370Glu Single submitter ⚠
- p.Gln83Pro Single submitter ⚠
- p.Glu107Gly Single submitter ⚠
- p.Glu300Gln Single submitter ⚠
- p.Glu300Lys Single submitter ⚠
- p.Glu7Ala Single submitter ⚠
- p.Gly174Glu Single submitter ⚠
- p.Gly283Ala Single submitter ⚠
- p.Gly303Asp Single submitter ⚠
- p.Gly324Glu Single submitter ⚠
- p.His113Arg Single submitter ⚠
- p.His5Tyr Single submitter ⚠
- p.Ile222Ser Single submitter ⚠
- p.Ile322Met Single submitter ⚠
- p.Ile8Thr Single submitter ⚠
- p.Leu198Arg Single submitter ⚠
- p.Leu227Met Single submitter ⚠
- p.Leu242Phe Single submitter ⚠
- p.Leu299Phe Single submitter ⚠
- p.Leu385Phe Single submitter ⚠
- p.Leu55Met Single submitter ⚠
- p.Leu86Ile Single submitter ⚠
- p.Lys190Asn Single submitter ⚠
- p.Lys263Glu Single submitter ⚠
- p.Lys42Asn Single submitter ⚠
- p.Met99Lys Single submitter ⚠
- p.Phe111Tyr Single submitter ⚠
- p.Phe133Leu Single submitter ⚠
- p.Phe138Leu Single submitter ⚠
- p.Phe140Tyr Single submitter ⚠
- p.Phe258Ser Single submitter ⚠
- p.Phe6Leu Single submitter ⚠
- p.Pro152Thr Single submitter ⚠
- p.Pro351Ala Single submitter ⚠
- p.Pro351Leu Single submitter ⚠
- p.Ser103Cys Single submitter ⚠
- p.Ser156Gly Single submitter ⚠
- p.Ser62Arg Single submitter ⚠
- p.Thr205Pro Single submitter ⚠
- p.Thr320Ser Single submitter ⚠
- p.Thr3Met Single submitter ⚠
- p.Trp77Arg Single submitter ⚠
- p.Tyr101Cys Single submitter ⚠
- p.Tyr187Cys Single submitter ⚠
- p.Val19Leu Single submitter ⚠
- p.Val200Met Single submitter ⚠
- p.Val279Ala Single submitter ⚠
- p.Val350Ala Single submitter ⚠
- p.Val350Phe Single submitter ⚠
- p.Val52Ile Single submitter ⚠