ART5 — 58 ClinVar variants
All ClinVar germline ART5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 53 flagged for review →
2 Benign · 3 Likely benign · 53 Uncertain significance
Full ART5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 53
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ART5 p.Ala182Thr Uncertain significance Single submitter
- ART5 p.Ala182Val Uncertain significance Single submitter
- ART5 p.Ala22Pro Uncertain significance Single submitter
- ART5 p.Ala22Thr Uncertain significance Single submitter
- ART5 p.Ala62Val Uncertain significance Single submitter
- ART5 p.Arg220His Uncertain significance Single submitter
- ART5 p.Arg234Thr Uncertain significance Single submitter
- ART5 p.Arg80Gln Uncertain significance Single submitter
- ART5 p.Asp37Asn Uncertain significance Single submitter
- ART5 p.Asp37His Uncertain significance Single submitter
- ART5 p.Gln251Lys Uncertain significance Single submitter
- ART5 p.Glu264Asp Uncertain significance Single submitter
- ART5 p.Glu69Lys Uncertain significance Single submitter
- ART5 p.Gly118Arg Uncertain significance Single submitter
- ART5 p.Gly119Cys Uncertain significance Single submitter
- ART5 p.Gly11Cys Uncertain significance Single submitter
- ART5 p.Gly149Ser Uncertain significance Single submitter
- ART5 p.Gly14Ser Uncertain significance Single submitter
- ART5 p.Gly81Glu Uncertain significance Single submitter
- ART5 p.Ile224Ser Uncertain significance Single submitter
- ART5 p.Leu141Pro Uncertain significance Single submitter
- ART5 p.Leu143Pro Uncertain significance Single submitter
- ART5 p.Leu64Pro Uncertain significance Single submitter
- ART5 p.Lys265Arg Uncertain significance Single submitter
- ART5 p.Phe159Leu Uncertain significance Single submitter
- ART5 p.Pro226Arg Uncertain significance Single submitter
- ART5 p.Ser175Phe Uncertain significance Single submitter
- ART5 p.Thr116Lys Uncertain significance Single submitter
- ART5 p.Thr278Arg Uncertain significance Single submitter
- ART5 p.Val157Leu Uncertain significance Single submitter
Predictors split 23
The independent predictors disagree with each other — read with care.
- ART5 p.Ala113Ser Uncertain significance Single submitter
- ART5 p.Ala208Thr Uncertain significance Single submitter
- ART5 p.Arg121Trp Uncertain significance Single submitter
- ART5 p.Arg139Gln Uncertain significance Single submitter
- ART5 p.Arg220Cys Uncertain significance Single submitter
- ART5 p.Asn92Ser Uncertain significance Single submitter
- ART5 p.Asp174Asn Uncertain significance Single submitter
- ART5 p.Asp174Tyr Uncertain significance Single submitter
- ART5 p.Glu56Gly Uncertain significance Single submitter
- ART5 p.Leu141Val Uncertain significance Single submitter
- ART5 p.Leu199Ile Uncertain significance Single submitter
- ART5 p.Leu199Pro Uncertain significance Single submitter
- ART5 p.Leu246Phe Uncertain significance Single submitter
- ART5 p.Met46Val Uncertain significance Single submitter
- ART5 p.Pro169Arg Uncertain significance Single submitter
- ART5 p.Pro226His Uncertain significance Single submitter
- ART5 p.Pro85Arg Uncertain significance Single submitter
- ART5 p.Ser147Asn Uncertain significance Single submitter
- ART5 p.Ser236Cys Uncertain significance Single submitter
- ART5 p.Ser242Gly Uncertain significance Single submitter
- ART5 p.Thr245Pro Uncertain significance Single submitter
- ART5 p.Val114Met Uncertain significance Single submitter
- ART5 p.Val98Ile Uncertain significance Single submitter
All ART5 variants
Benign 2
- p.Ser271Thr Multiple submitters
- p.Glu156Lys Single submitter
Likely benign 3
- p.Ala272Val Single submitter
- p.Arg79His Single submitter
- p.Gly11Ser Single submitter
Uncertain significance 53
- p.Ala113Ser Single submitter ⚠
- p.Ala182Thr Single submitter ⚠
- p.Ala182Val Single submitter ⚠
- p.Ala208Thr Single submitter ⚠
- p.Ala22Pro Single submitter ⚠
- p.Ala22Thr Single submitter ⚠
- p.Ala62Val Single submitter ⚠
- p.Arg121Trp Single submitter ⚠
- p.Arg139Gln Single submitter ⚠
- p.Arg220Cys Single submitter ⚠
- p.Arg220His Single submitter ⚠
- p.Arg234Thr Single submitter ⚠
- p.Arg80Gln Single submitter ⚠
- p.Asn92Ser Single submitter ⚠
- p.Asp174Asn Single submitter ⚠
- p.Asp174Tyr Single submitter ⚠
- p.Asp37Asn Single submitter ⚠
- p.Asp37His Single submitter ⚠
- p.Gln251Lys Single submitter ⚠
- p.Glu264Asp Single submitter ⚠
- p.Glu56Gly Single submitter ⚠
- p.Glu69Lys Single submitter ⚠
- p.Gly118Arg Single submitter ⚠
- p.Gly119Cys Single submitter ⚠
- p.Gly11Cys Single submitter ⚠
- p.Gly149Ser Single submitter ⚠
- p.Gly14Ser Single submitter ⚠
- p.Gly81Glu Single submitter ⚠
- p.Ile224Ser Single submitter ⚠
- p.Leu141Pro Single submitter ⚠
- p.Leu141Val Single submitter ⚠
- p.Leu143Pro Single submitter ⚠
- p.Leu199Ile Single submitter ⚠
- p.Leu199Pro Single submitter ⚠
- p.Leu246Phe Single submitter ⚠
- p.Leu64Pro Single submitter ⚠
- p.Lys265Arg Single submitter ⚠
- p.Met46Val Single submitter ⚠
- p.Phe159Leu Single submitter ⚠
- p.Pro169Arg Single submitter ⚠
- p.Pro226Arg Single submitter ⚠
- p.Pro226His Single submitter ⚠
- p.Pro85Arg Single submitter ⚠
- p.Ser147Asn Single submitter ⚠
- p.Ser175Phe Single submitter ⚠
- p.Ser236Cys Single submitter ⚠
- p.Ser242Gly Single submitter ⚠
- p.Thr116Lys Single submitter ⚠
- p.Thr245Pro Single submitter ⚠
- p.Thr278Arg Single submitter ⚠
- p.Val114Met Single submitter ⚠
- p.Val157Leu Single submitter ⚠
- p.Val98Ile Single submitter ⚠