ASB1 — 49 ClinVar variants
All ClinVar germline ASB1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 46 flagged for review →
3 Likely benign · 46 Uncertain significance
Full ASB1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 46
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ASB1 p.Ala11Gly Uncertain significance Single submitter
- ASB1 p.Ala85Val Uncertain significance Single submitter
- ASB1 p.Arg144Cys Uncertain significance Single submitter
- ASB1 p.Arg144His Uncertain significance Single submitter
- ASB1 p.Arg156Gln Uncertain significance Single submitter
- ASB1 p.Arg165Ser Uncertain significance Single submitter
- ASB1 p.Arg186Gln Uncertain significance Single submitter
- ASB1 p.Arg18Gly Uncertain significance Single submitter
- ASB1 p.Arg276Thr Uncertain significance Single submitter
- ASB1 p.Arg83Gln Uncertain significance Single submitter
- ASB1 p.Arg99Gln Uncertain significance Single submitter
- ASB1 p.Asn223His Uncertain significance Single submitter
- ASB1 p.Glu22Ala Uncertain significance Single submitter
- ASB1 p.Gly14Ser Uncertain significance Single submitter
- ASB1 p.Gly17Asp Uncertain significance Single submitter
- ASB1 p.Gly9Ala Uncertain significance Single submitter
- ASB1 p.Gly9Arg Uncertain significance Single submitter
- ASB1 p.Gly9Glu Uncertain significance Single submitter
- ASB1 p.His203Arg Uncertain significance Single submitter
- ASB1 p.Ile319Val Uncertain significance Single submitter
- ASB1 p.Leu130Phe Uncertain significance Single submitter
- ASB1 p.Leu324Pro Uncertain significance Single submitter
- ASB1 p.Leu53Phe Uncertain significance Single submitter
- ASB1 p.Pro32Leu Uncertain significance Single submitter
- ASB1 p.Pro7Ala Uncertain significance Single submitter
- ASB1 p.Ser270Leu Uncertain significance Single submitter
- ASB1 p.Ser321Leu Uncertain significance Single submitter
- ASB1 p.Ser6Gly Uncertain significance Single submitter
- ASB1 p.Val257Leu Uncertain significance Single submitter
- ASB1 p.Val47Ile Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- ASB1 p.Ala216Val Uncertain significance Single submitter
- ASB1 p.Arg141Trp Uncertain significance Single submitter
- ASB1 p.Arg18His Uncertain significance Single submitter
- ASB1 p.Arg245Cys Uncertain significance Single submitter
- ASB1 p.Arg304His Uncertain significance Single submitter
- ASB1 p.Arg315Gln Uncertain significance Single submitter
- ASB1 p.Arg40Lys Uncertain significance Single submitter
- ASB1 p.Arg63Gln Uncertain significance Single submitter
- ASB1 p.Arg63Trp Uncertain significance Single submitter
- ASB1 p.Gly167Arg Uncertain significance Single submitter
- ASB1 p.Gly5Asp Uncertain significance Single submitter
- ASB1 p.Leu124Val Uncertain significance Single submitter
- ASB1 p.Leu205Phe Uncertain significance Single submitter
- ASB1 p.Leu263Val Uncertain significance Single submitter
- ASB1 p.Pro283Leu Uncertain significance Single submitter
- ASB1 p.Ser55Asn Uncertain significance Single submitter
All ASB1 variants
Likely benign 3
- p.Arg153= Single submitter
- p.Arg183Pro Single submitter
- p.Gln181Arg Single submitter
Uncertain significance 46
- p.Ala11Gly Single submitter ⚠
- p.Ala216Val Single submitter ⚠
- p.Ala85Val Single submitter ⚠
- p.Arg141Trp Single submitter ⚠
- p.Arg144Cys Single submitter ⚠
- p.Arg144His Single submitter ⚠
- p.Arg156Gln Single submitter ⚠
- p.Arg165Ser Single submitter ⚠
- p.Arg186Gln Single submitter ⚠
- p.Arg18Gly Single submitter ⚠
- p.Arg18His Single submitter ⚠
- p.Arg245Cys Single submitter ⚠
- p.Arg276Thr Single submitter ⚠
- p.Arg304His Single submitter ⚠
- p.Arg315Gln Single submitter ⚠
- p.Arg40Lys Single submitter ⚠
- p.Arg63Gln Single submitter ⚠
- p.Arg63Trp Single submitter ⚠
- p.Arg83Gln Single submitter ⚠
- p.Arg99Gln Single submitter ⚠
- p.Asn223His Single submitter ⚠
- p.Glu22Ala Single submitter ⚠
- p.Gly14Ser Single submitter ⚠
- p.Gly167Arg Single submitter ⚠
- p.Gly17Asp Single submitter ⚠
- p.Gly5Asp Single submitter ⚠
- p.Gly9Ala Single submitter ⚠
- p.Gly9Arg Single submitter ⚠
- p.Gly9Glu Single submitter ⚠
- p.His203Arg Single submitter ⚠
- p.Ile319Val Single submitter ⚠
- p.Leu124Val Single submitter ⚠
- p.Leu130Phe Single submitter ⚠
- p.Leu205Phe Single submitter ⚠
- p.Leu263Val Single submitter ⚠
- p.Leu324Pro Single submitter ⚠
- p.Leu53Phe Single submitter ⚠
- p.Pro283Leu Single submitter ⚠
- p.Pro32Leu Single submitter ⚠
- p.Pro7Ala Single submitter ⚠
- p.Ser270Leu Single submitter ⚠
- p.Ser321Leu Single submitter ⚠
- p.Ser55Asn Single submitter ⚠
- p.Ser6Gly Single submitter ⚠
- p.Val257Leu Single submitter ⚠
- p.Val47Ile Single submitter ⚠