ASB4 — 68 ClinVar variants
All ClinVar germline ASB4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 68 flagged for review →
68 Uncertain significance
Full ASB4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 68
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 40
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ASB4 p.Ala13Thr Uncertain significance Single submitter
- ASB4 p.Ala206Val Uncertain significance Single submitter
- ASB4 p.Ala35Ser Uncertain significance Single submitter
- ASB4 p.Arg349Thr Uncertain significance Single submitter
- ASB4 p.Asn119Ser Uncertain significance Single submitter
- ASB4 p.Asp282Gly Uncertain significance Single submitter
- ASB4 p.Cys378Tyr Uncertain significance Single submitter
- ASB4 p.Gln173Arg Uncertain significance Single submitter
- ASB4 p.Gln225Arg Uncertain significance Single submitter
- ASB4 p.Gln309Arg Uncertain significance Single submitter
- ASB4 p.Glu420Gln Uncertain significance Single submitter
- ASB4 p.Glu422Lys Uncertain significance Single submitter
- ASB4 p.Glu53Asp Uncertain significance Single submitter
- ASB4 p.Glu89Asp Uncertain significance Single submitter
- ASB4 p.Gly198Glu Uncertain significance Single submitter
- ASB4 p.Gly31Arg Uncertain significance Single submitter
- ASB4 p.His145Arg Uncertain significance Single submitter
- ASB4 p.His197Gln Uncertain significance Single submitter
- ASB4 p.His231Pro Uncertain significance Single submitter
- ASB4 p.His332Arg Uncertain significance Single submitter
- ASB4 p.His386Asn Uncertain significance Single submitter
- ASB4 p.Ile101Val Uncertain significance Single submitter
- ASB4 p.Ile153Thr Uncertain significance Single submitter
- ASB4 p.Ile36Asn Uncertain significance Single submitter
- ASB4 p.Ile425Val Uncertain significance Single submitter
- ASB4 p.Leu144Phe Uncertain significance Single submitter
- ASB4 p.Leu417Ser Uncertain significance Single submitter
- ASB4 p.Leu79His Uncertain significance Single submitter
- ASB4 p.Met117Ile Uncertain significance Single submitter
- ASB4 p.Met208Thr Uncertain significance Single submitter
- ASB4 p.Met237Leu Uncertain significance Single submitter
- ASB4 p.Met281Thr Uncertain significance Single submitter
- ASB4 p.Met55Leu Uncertain significance Single submitter
- ASB4 p.Phe48Ser Uncertain significance Single submitter
- ASB4 p.Pro255Arg Uncertain significance Single submitter
- ASB4 p.Trp354Arg Uncertain significance Single submitter
- ASB4 p.Trp367Leu Uncertain significance Single submitter
- ASB4 p.Val160Ile Uncertain significance Single submitter
- ASB4 p.Val376Leu Uncertain significance Single submitter
- ASB4 p.Val83Leu Uncertain significance Single submitter
Predictors split 28
The independent predictors disagree with each other — read with care.
- ASB4 p.Ala156Ser Uncertain significance Single submitter
- ASB4 p.Ala182Thr Uncertain significance Single submitter
- ASB4 p.Ala58Thr Uncertain significance Single submitter
- ASB4 p.Ala6Asp Uncertain significance Single submitter
- ASB4 p.Arg236Cys Uncertain significance Single submitter
- ASB4 p.Arg299Cys Uncertain significance Single submitter
- ASB4 p.Arg394Gly Uncertain significance Single submitter
- ASB4 p.Asn134Ser Uncertain significance Single submitter
- ASB4 p.Asn165Lys Uncertain significance Single submitter
- ASB4 p.Asn28Ser Uncertain significance Single submitter
- ASB4 p.Asp362Gly Uncertain significance Single submitter
- ASB4 p.Cys263Ser Uncertain significance Single submitter
- ASB4 p.Cys400Ser Uncertain significance Single submitter
- ASB4 p.Glu116Lys Uncertain significance Single submitter
- ASB4 p.Glu305Lys Uncertain significance Single submitter
- ASB4 p.His265Gln Uncertain significance Single submitter
- ASB4 p.His97Arg Uncertain significance Single submitter
- ASB4 p.Ile338Thr Uncertain significance Single submitter
- ASB4 p.Leu373Phe Uncertain significance Single submitter
- ASB4 p.Leu373Val Uncertain significance Single submitter
- ASB4 p.Lys18Thr Uncertain significance Single submitter
- ASB4 p.Pro359Thr Uncertain significance Single submitter
- ASB4 p.Ser408Cys Uncertain significance Single submitter
- ASB4 p.Ser74Phe Uncertain significance Single submitter
- ASB4 p.Thr149Ala Uncertain significance Single submitter
- ASB4 p.Thr181Ser Uncertain significance Single submitter
- ASB4 p.Tyr227His Uncertain significance Single submitter
- ASB4 p.Val44Met Uncertain significance Single submitter
All ASB4 variants
Uncertain significance 68
- p.Ala13Thr Single submitter ⚠
- p.Ala156Ser Single submitter ⚠
- p.Ala182Thr Single submitter ⚠
- p.Ala206Val Single submitter ⚠
- p.Ala35Ser Single submitter ⚠
- p.Ala58Thr Single submitter ⚠
- p.Ala6Asp Single submitter ⚠
- p.Arg236Cys Single submitter ⚠
- p.Arg299Cys Single submitter ⚠
- p.Arg349Thr Single submitter ⚠
- p.Arg394Gly Single submitter ⚠
- p.Asn119Ser Single submitter ⚠
- p.Asn134Ser Single submitter ⚠
- p.Asn165Lys Single submitter ⚠
- p.Asn28Ser Single submitter ⚠
- p.Asp282Gly Single submitter ⚠
- p.Asp362Gly Single submitter ⚠
- p.Cys263Ser Single submitter ⚠
- p.Cys378Tyr Single submitter ⚠
- p.Cys400Ser Single submitter ⚠
- p.Gln173Arg Single submitter ⚠
- p.Gln225Arg Single submitter ⚠
- p.Gln309Arg Single submitter ⚠
- p.Glu116Lys Single submitter ⚠
- p.Glu305Lys Single submitter ⚠
- p.Glu420Gln Single submitter ⚠
- p.Glu422Lys Single submitter ⚠
- p.Glu53Asp Single submitter ⚠
- p.Glu89Asp Single submitter ⚠
- p.Gly198Glu Single submitter ⚠
- p.Gly31Arg Single submitter ⚠
- p.His145Arg Single submitter ⚠
- p.His197Gln Single submitter ⚠
- p.His231Pro Single submitter ⚠
- p.His265Gln Single submitter ⚠
- p.His332Arg Single submitter ⚠
- p.His386Asn Single submitter ⚠
- p.His97Arg Single submitter ⚠
- p.Ile101Val Single submitter ⚠
- p.Ile153Thr Single submitter ⚠
- p.Ile338Thr Single submitter ⚠
- p.Ile36Asn Single submitter ⚠
- p.Ile425Val Single submitter ⚠
- p.Leu144Phe Single submitter ⚠
- p.Leu373Phe Single submitter ⚠
- p.Leu373Val Single submitter ⚠
- p.Leu417Ser Single submitter ⚠
- p.Leu79His Single submitter ⚠
- p.Lys18Thr Single submitter ⚠
- p.Met117Ile Single submitter ⚠
- p.Met208Thr Single submitter ⚠
- p.Met237Leu Single submitter ⚠
- p.Met281Thr Single submitter ⚠
- p.Met55Leu Single submitter ⚠
- p.Phe48Ser Single submitter ⚠
- p.Pro255Arg Single submitter ⚠
- p.Pro359Thr Single submitter ⚠
- p.Ser408Cys Single submitter ⚠
- p.Ser74Phe Single submitter ⚠
- p.Thr149Ala Single submitter ⚠
- p.Thr181Ser Single submitter ⚠
- p.Trp354Arg Single submitter ⚠
- p.Trp367Leu Single submitter ⚠
- p.Tyr227His Single submitter ⚠
- p.Val160Ile Single submitter ⚠
- p.Val376Leu Single submitter ⚠
- p.Val44Met Single submitter ⚠
- p.Val83Leu Single submitter ⚠