ATAD2B — 130 ClinVar variants
All ClinVar germline ATAD2B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 121 flagged for review →
1 Benign · 7 Likely benign · 122 Uncertain significance
Full ATAD2B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 121
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 86
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ATAD2B p.Ala1111Pro Uncertain significance Single submitter
- ATAD2B p.Ala1232Pro Uncertain significance Single submitter
- ATAD2B p.Ala1375Val Uncertain significance Single submitter
- ATAD2B p.Ala31Ser Uncertain significance Single submitter
- ATAD2B p.Ala692Val Uncertain significance Single submitter
- ATAD2B p.Arg1085Gly Uncertain significance Single submitter
- ATAD2B p.Arg112Gln Uncertain significance Single submitter
- ATAD2B p.Arg1133Gln Uncertain significance Single submitter
- ATAD2B p.Arg1368Cys Uncertain significance Single submitter
- ATAD2B p.Arg147Gln Uncertain significance Single submitter
- ATAD2B p.Arg666Cys Uncertain significance Single submitter
- ATAD2B p.Arg775Gln Uncertain significance Single submitter
- ATAD2B p.Asn1205His Uncertain significance Single submitter
- ATAD2B p.Asn1230Asp Uncertain significance Single submitter
- ATAD2B p.Asn1240Ser Uncertain significance Single submitter
- ATAD2B p.Asn174Thr Uncertain significance Single submitter
- ATAD2B p.Asn590Asp Uncertain significance Single submitter
- ATAD2B p.Asn688Ser Uncertain significance Single submitter
- ATAD2B p.Asn724Lys Uncertain significance Single submitter
- ATAD2B p.Asp1410Glu Uncertain significance Single submitter
- ATAD2B p.Asp155Glu Uncertain significance Single submitter
- ATAD2B p.Asp222Glu Uncertain significance Single submitter
- ATAD2B p.Asp722Glu Uncertain significance Single submitter
- ATAD2B p.Cys1130Tyr Uncertain significance Single submitter
- ATAD2B p.Gln1116Glu Uncertain significance Single submitter
- ATAD2B p.Gln1255His Uncertain significance Single submitter
- ATAD2B p.Gln187His Uncertain significance Single submitter
- ATAD2B p.Gln583Lys Uncertain significance Single submitter
- ATAD2B p.Gln908Arg Uncertain significance Single submitter
- ATAD2B p.Gln943Glu Uncertain significance Single submitter
- ATAD2B p.Glu1109Lys Uncertain significance Single submitter
- ATAD2B p.Glu1330Gln Uncertain significance Single submitter
- ATAD2B p.Gly1199Glu Uncertain significance Single submitter
- ATAD2B p.Gly1265Val Uncertain significance Single submitter
- ATAD2B p.Gly138Asp Uncertain significance Single submitter
- ATAD2B p.Gly33Arg Uncertain significance Single submitter
- ATAD2B p.Gly540Val Uncertain significance Single submitter
- ATAD2B p.His655Arg Uncertain significance Single submitter
- ATAD2B p.His789Asp Uncertain significance Single submitter
- ATAD2B p.Ile1212Thr Uncertain significance Single submitter
- ATAD2B p.Ile1395Arg Uncertain significance Single submitter
- ATAD2B p.Ile248Met Uncertain significance Single submitter
- ATAD2B p.Ile393Leu Uncertain significance Single submitter
- ATAD2B p.Ile678Val Uncertain significance Single submitter
- ATAD2B p.Ile703Val Uncertain significance Single submitter
- ATAD2B p.Ile712Thr Uncertain significance Single submitter
- ATAD2B p.Ile895Val Uncertain significance Single submitter
- ATAD2B p.Leu117Val Uncertain significance Single submitter
- ATAD2B p.Leu1244Val Uncertain significance Single submitter
- ATAD2B p.Leu1251Val Uncertain significance Single submitter
- ATAD2B p.Leu1332Val Uncertain significance Single submitter
- ATAD2B p.Leu421Phe Uncertain significance Single submitter
- ATAD2B p.Leu68Val Uncertain significance Single submitter
- ATAD2B p.Leu937Val Uncertain significance Single submitter
- ATAD2B p.Leu960Ser Uncertain significance Single submitter
- ATAD2B p.Leu9Val Uncertain significance Single submitter
- ATAD2B p.Lys1137Arg Uncertain significance Single submitter
- ATAD2B p.Lys1352Glu Uncertain significance Single submitter
- ATAD2B p.Lys150Glu Uncertain significance Single submitter
- ATAD2B p.Lys464Ile Uncertain significance Single submitter
- ATAD2B p.Lys985Thr Uncertain significance Single submitter
- ATAD2B p.Met1203Val Uncertain significance Single submitter
- ATAD2B p.Met1453Thr Uncertain significance Single submitter
- ATAD2B p.Pro1096His Uncertain significance Single submitter
- ATAD2B p.Pro1281Thr Uncertain significance Single submitter
- ATAD2B p.Pro1345Leu Uncertain significance Single submitter
- ATAD2B p.Pro738Leu Uncertain significance Single submitter
- ATAD2B p.Ser1321Leu Uncertain significance Single submitter
- ATAD2B p.Ser35Gly Uncertain significance Single submitter
- ATAD2B p.Ser40Phe Uncertain significance Single submitter
- ATAD2B p.Ser704Cys Uncertain significance Single submitter
- ATAD2B p.Ser706Arg Uncertain significance Single submitter
- ATAD2B p.Thr1164Ser Uncertain significance Single submitter
- ATAD2B p.Thr1322Ala Uncertain significance Single submitter
- ATAD2B p.Thr311Ser Uncertain significance Single submitter
- ATAD2B p.Thr67Pro Uncertain significance Single submitter
- ATAD2B p.Trp1123Cys Uncertain significance Single submitter
- ATAD2B p.Tyr1169Cys Uncertain significance Single submitter
- ATAD2B p.Tyr495Ser Uncertain significance Single submitter
- ATAD2B p.Val1391Leu Uncertain significance Single submitter
- ATAD2B p.Val189Ile Uncertain significance Single submitter
- ATAD2B p.Val74Ile Uncertain significance Single submitter
- ATAD2B p.Val76Ala Uncertain significance Single submitter
- ATAD2B p.Val85Ile Uncertain significance Single submitter
- ATAD2B p.Val998Ile Uncertain significance Single submitter
- ATAD2B p.Leu1404Trp Uncertain significance No assertion criteria
Predictors split 35
The independent predictors disagree with each other — read with care.
- ATAD2B p.Ala50Asp Uncertain significance Single submitter
- ATAD2B p.Ala975Thr Uncertain significance Single submitter
- ATAD2B p.Arg1433Cys Uncertain significance Single submitter
- ATAD2B p.Arg170His Uncertain significance Single submitter
- ATAD2B p.Arg237Gln Uncertain significance Single submitter
- ATAD2B p.Arg398Gln Uncertain significance Single submitter
- ATAD2B p.Arg49His Uncertain significance Single submitter
- ATAD2B p.Arg91Cys Uncertain significance Single submitter
- ATAD2B p.Asp1437Asn Uncertain significance Single submitter
- ATAD2B p.Asp462Gly Uncertain significance Single submitter
- ATAD2B p.Cys1210Arg Uncertain significance Single submitter
- ATAD2B p.Glu1305Ala Uncertain significance Single submitter
- ATAD2B p.Glu274Gly Uncertain significance Single submitter
- ATAD2B p.Glu909Gln Uncertain significance Single submitter
- ATAD2B p.Glu997Lys Uncertain significance Single submitter
- ATAD2B p.Gly373Asp Uncertain significance Single submitter
- ATAD2B p.His1060Tyr Uncertain significance Single submitter
- ATAD2B p.Ile402Val Uncertain significance Single submitter
- ATAD2B p.Ile501Val Uncertain significance Single submitter
- ATAD2B p.Ile660Thr Uncertain significance Single submitter
- ATAD2B p.Lys1056Gln Uncertain significance Single submitter
- ATAD2B p.Lys1079Glu Uncertain significance Single submitter
- ATAD2B p.Lys47Asn Uncertain significance Single submitter
- ATAD2B p.Lys985Gln Uncertain significance Single submitter
- ATAD2B p.Phe38Leu Uncertain significance Single submitter
- ATAD2B p.Pro920Arg Uncertain significance Single submitter
- ATAD2B p.Ser1006Ala Uncertain significance Single submitter
- ATAD2B p.Ser1304Phe Uncertain significance Single submitter
- ATAD2B p.Ser1425Tyr Uncertain significance Single submitter
- ATAD2B p.Ser323Arg Uncertain significance Single submitter
- ATAD2B p.Ser649Arg Uncertain significance Single submitter
- ATAD2B p.Ser875Arg Uncertain significance Single submitter
- ATAD2B p.Ser8Ala Uncertain significance Single submitter
- ATAD2B p.Ser98Cys Uncertain significance Single submitter
- ATAD2B p.Val661Met Uncertain significance Single submitter
All ATAD2B variants
Benign 1
- p.Leu68= Multiple submitters
Likely benign 7
- p.Ala701= Single submitter
- p.Arg359= Single submitter
- p.Asn1266Ser Single submitter
- p.Ile747Val Single submitter
- p.Ser1098Gly Single submitter
- p.Thr1322Ile Single submitter
- p.Val1351Ile Single submitter
Uncertain significance 122
- p.Ala1111Pro Single submitter ⚠
- p.Ala1232Pro Single submitter ⚠
- p.Ala1375Val Single submitter ⚠
- p.Ala31Ser Single submitter ⚠
- p.Ala50Asp Single submitter ⚠
- p.Ala692Val Single submitter ⚠
- p.Ala975Thr Single submitter ⚠
- p.Arg1085Gly Single submitter ⚠
- p.Arg112Gln Single submitter ⚠
- p.Arg1133Gln Single submitter ⚠
- p.Arg1368Cys Single submitter ⚠
- p.Arg1433Cys Single submitter ⚠
- p.Arg147Gln Single submitter ⚠
- p.Arg170His Single submitter ⚠
- p.Arg237Gln Single submitter ⚠
- p.Arg398Gln Single submitter ⚠
- p.Arg49His Single submitter ⚠
- p.Arg666Cys Single submitter ⚠
- p.Arg775Gln Single submitter ⚠
- p.Arg91Cys Single submitter ⚠
- p.Asn1205His Single submitter ⚠
- p.Asn1230Asp Single submitter ⚠
- p.Asn1240Ser Single submitter ⚠
- p.Asn174Thr Single submitter ⚠
- p.Asn590Asp Single submitter ⚠
- p.Asn688Ser Single submitter ⚠
- p.Asn724Lys Single submitter ⚠
- p.Asp1410Glu Single submitter ⚠
- p.Asp1437Asn Single submitter ⚠
- p.Asp155Glu Single submitter ⚠
- p.Asp222Glu Single submitter ⚠
- p.Asp462Gly Single submitter ⚠
- p.Asp722Glu Single submitter ⚠
- p.Cys1130Tyr Single submitter ⚠
- p.Cys1210Arg Single submitter ⚠
- p.Gln1116Glu Single submitter ⚠
- p.Gln1255His Single submitter ⚠
- p.Gln187His Single submitter ⚠
- p.Gln583Lys Single submitter ⚠
- p.Gln908Arg Single submitter ⚠
- p.Gln943Glu Single submitter ⚠
- p.Glu1109Lys Single submitter ⚠
- p.Glu1305Ala Single submitter ⚠
- p.Glu1330Gln Single submitter ⚠
- p.Glu274Gly Single submitter ⚠
- p.Glu909Gln Single submitter ⚠
- p.Glu997Lys Single submitter ⚠
- p.Gly1199Glu Single submitter ⚠
- p.Gly1265Val Single submitter ⚠
- p.Gly138Asp Single submitter ⚠
- p.Gly33Arg Single submitter ⚠
- p.Gly373Asp Single submitter ⚠
- p.Gly540Val Single submitter ⚠
- p.His1060Tyr Single submitter ⚠
- p.His655Arg Single submitter ⚠
- p.His789Asp Single submitter ⚠
- p.Ile1212Thr Single submitter ⚠
- p.Ile1395Arg Single submitter ⚠
- p.Ile248Met Single submitter ⚠
- p.Ile393Leu Single submitter ⚠
- p.Ile402Val Single submitter ⚠
- p.Ile501Val Single submitter ⚠
- p.Ile660Thr Single submitter ⚠
- p.Ile678Val Single submitter ⚠
- p.Ile703Val Single submitter ⚠
- p.Ile712Thr Single submitter ⚠
- p.Ile895Val Single submitter ⚠
- p.Leu117Val Single submitter ⚠
- p.Leu1244Val Single submitter ⚠
- p.Leu1251Val Single submitter ⚠
- p.Leu1332Val Single submitter ⚠
- p.Leu421Phe Single submitter ⚠
- p.Leu68Val Single submitter ⚠
- p.Leu937Val Single submitter ⚠
- p.Leu960Ser Single submitter ⚠
- p.Leu9Val Single submitter ⚠
- p.Lys1056Gln Single submitter ⚠
- p.Lys1079Glu Single submitter ⚠
- p.Lys1137Arg Single submitter ⚠
- p.Lys1352Glu Single submitter ⚠
- p.Lys150Glu Single submitter ⚠
- p.Lys464Ile Single submitter ⚠
- p.Lys47Asn Single submitter ⚠
- p.Lys985Gln Single submitter ⚠
- p.Lys985Thr Single submitter ⚠
- p.Met1203Val Single submitter ⚠
- p.Met1453Thr Single submitter ⚠
- p.Met469fs Single submitter
- p.Phe38Leu Single submitter ⚠
- p.Pro1096His Single submitter ⚠
- p.Pro1281Thr Single submitter ⚠
- p.Pro1345Leu Single submitter ⚠
- p.Pro738Leu Single submitter ⚠
- p.Pro920Arg Single submitter ⚠
- p.Ser1006Ala Single submitter ⚠
- p.Ser1304Phe Single submitter ⚠
- p.Ser1321Leu Single submitter ⚠
- p.Ser1425Tyr Single submitter ⚠
- p.Ser323Arg Single submitter ⚠
- p.Ser35Gly Single submitter ⚠
- p.Ser40Phe Single submitter ⚠
- p.Ser649Arg Single submitter ⚠
- p.Ser704Cys Single submitter ⚠
- p.Ser706Arg Single submitter ⚠
- p.Ser875Arg Single submitter ⚠
- p.Ser8Ala Single submitter ⚠
- p.Ser98Cys Single submitter ⚠
- p.Thr1164Ser Single submitter ⚠
- p.Thr1322Ala Single submitter ⚠
- p.Thr311Ser Single submitter ⚠
- p.Thr67Pro Single submitter ⚠
- p.Trp1123Cys Single submitter ⚠
- p.Tyr1169Cys Single submitter ⚠
- p.Tyr495Ser Single submitter ⚠
- p.Val1391Leu Single submitter ⚠
- p.Val189Ile Single submitter ⚠
- p.Val661Met Single submitter ⚠
- p.Val74Ile Single submitter ⚠
- p.Val76Ala Single submitter ⚠
- p.Val85Ile Single submitter ⚠
- p.Val998Ile Single submitter ⚠
- p.Leu1404Trp No assertion criteria ⚠