ATG10 — 30 ClinVar variants
All ClinVar germline ATG10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 27 flagged for review →
2 Likely benign · 28 Uncertain significance
Full ATG10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 27
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ATG10 p.Arg139Gln Uncertain significance Single submitter
- ATG10 p.Arg139Leu Uncertain significance Single submitter
- ATG10 p.Arg14Leu Uncertain significance Single submitter
- ATG10 p.Arg217Gln Uncertain significance Single submitter
- ATG10 p.Asn187Thr Uncertain significance Single submitter
- ATG10 p.Asp119Gly Uncertain significance Single submitter
- ATG10 p.Asp81Ala Uncertain significance Single submitter
- ATG10 p.Cys82Arg Uncertain significance Single submitter
- ATG10 p.Glu3Lys Uncertain significance Single submitter
- ATG10 p.Glu9Lys Uncertain significance Single submitter
- ATG10 p.Gly27Cys Uncertain significance Single submitter
- ATG10 p.His164Arg Uncertain significance Single submitter
- ATG10 p.His164Tyr Uncertain significance Single submitter
- ATG10 p.Ile155Val Uncertain significance Single submitter
- ATG10 p.Lys21Glu Uncertain significance Single submitter
- ATG10 p.Lys36Glu Uncertain significance Single submitter
- ATG10 p.Met71Thr Uncertain significance Single submitter
- ATG10 p.Pro220Ala Uncertain significance Single submitter
- ATG10 p.Val186Ile Uncertain significance Single submitter
- ATG10 p.Val199Ile Uncertain significance Single submitter
- ATG10 p.Val219Ile Uncertain significance Single submitter
- ATG10 p.Val93Met Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All ATG10 variants
Likely benign 2
- p.Arg14His Single submitter
- p.Glu92Lys Single submitter
Uncertain significance 28
- p.Arg139Gln Single submitter ⚠
- p.Arg139Leu Single submitter ⚠
- p.Arg14Leu Single submitter ⚠
- p.Arg217Gln Single submitter ⚠
- p.Asn187Thr Single submitter ⚠
- p.Asp119Gly Single submitter ⚠
- p.Asp146Gly Single submitter ⚠
- p.Asp81Ala Single submitter ⚠
- p.Cys82Arg Single submitter ⚠
- p.Glu3Lys Single submitter ⚠
- p.Glu9Lys Single submitter ⚠
- p.Gly27Cys Single submitter ⚠
- p.Gly41Asp Single submitter ⚠
- p.His164Arg Single submitter ⚠
- p.His164Tyr Single submitter ⚠
- p.Ile155Val Single submitter ⚠
- p.Leu123Phe Single submitter ⚠
- p.Lys21Glu Single submitter ⚠
- p.Lys36Glu Single submitter ⚠
- p.Met71Thr Single submitter ⚠
- p.Pro220Ala Single submitter ⚠
- p.Trp129Arg Single submitter ⚠
- p.Val108Met Single submitter
- p.Val110Ile Single submitter ⚠
- p.Val186Ile Single submitter ⚠
- p.Val199Ile Single submitter ⚠
- p.Val219Ile Single submitter ⚠
- p.Val93Met Single submitter ⚠