ATOSB — 81 ClinVar variants
All ClinVar germline ATOSB variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 77 flagged for review →
4 Likely benign · 77 Uncertain significance
Full ATOSB gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 77
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 55
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ATOSB p.Ala161Val Uncertain significance Single submitter
- ATOSB p.Ala194Thr Uncertain significance Single submitter
- ATOSB p.Ala220Thr Uncertain significance Single submitter
- ATOSB p.Ala27Ser Uncertain significance Single submitter
- ATOSB p.Ala6Val Uncertain significance Single submitter
- ATOSB p.Arg490Gln Uncertain significance Single submitter
- ATOSB p.Arg510Trp Uncertain significance Single submitter
- ATOSB p.Asp187Asn Uncertain significance Single submitter
- ATOSB p.Asp299Ala Uncertain significance Single submitter
- ATOSB p.Gln49His Uncertain significance Single submitter
- ATOSB p.Glu173Lys Uncertain significance Single submitter
- ATOSB p.Glu256Asp Uncertain significance Single submitter
- ATOSB p.Glu74Asp Uncertain significance Single submitter
- ATOSB p.Glu89Gln Uncertain significance Single submitter
- ATOSB p.Gly139Arg Uncertain significance Single submitter
- ATOSB p.Gly169Arg Uncertain significance Single submitter
- ATOSB p.Gly172Glu Uncertain significance Single submitter
- ATOSB p.Gly197Arg Uncertain significance Single submitter
- ATOSB p.Gly206Ser Uncertain significance Single submitter
- ATOSB p.Gly30Ala Uncertain significance Single submitter
- ATOSB p.Gly369Asp Uncertain significance Single submitter
- ATOSB p.Gly40Ala Uncertain significance Single submitter
- ATOSB p.Gly40Glu Uncertain significance Single submitter
- ATOSB p.Gly40Val Uncertain significance Single submitter
- ATOSB p.His156Pro Uncertain significance Single submitter
- ATOSB p.His461Arg Uncertain significance Single submitter
- ATOSB p.His530Leu Uncertain significance Single submitter
- ATOSB p.Ile503Thr Uncertain significance Single submitter
- ATOSB p.Leu463Pro Uncertain significance Single submitter
- ATOSB p.Met34Thr Uncertain significance Single submitter
- ATOSB p.Met451Ile Uncertain significance Single submitter
- ATOSB p.Met456Lys Uncertain significance Single submitter
- ATOSB p.Pro143Ala Uncertain significance Single submitter
- ATOSB p.Pro143Leu Uncertain significance Single submitter
- ATOSB p.Pro143Thr Uncertain significance Single submitter
- ATOSB p.Pro144Leu Uncertain significance Single submitter
- ATOSB p.Pro14Leu Uncertain significance Single submitter
- ATOSB p.Pro18Ser Uncertain significance Single submitter
- ATOSB p.Pro21Leu Uncertain significance Single submitter
- ATOSB p.Pro262Ser Uncertain significance Single submitter
- ATOSB p.Pro293Ser Uncertain significance Single submitter
- ATOSB p.Pro333Ala Uncertain significance Single submitter
- ATOSB p.Pro333Ser Uncertain significance Single submitter
- ATOSB p.Pro538Arg Uncertain significance Single submitter
- ATOSB p.Pro8Leu Uncertain significance Single submitter
- ATOSB p.Pro93Ala Uncertain significance Single submitter
- ATOSB p.Ser319Arg Uncertain significance Single submitter
- ATOSB p.Ser323Arg Uncertain significance Single submitter
- ATOSB p.Ser332Thr Uncertain significance Single submitter
- ATOSB p.Thr185Ala Uncertain significance Single submitter
- ATOSB p.Thr347Ala Uncertain significance Single submitter
- ATOSB p.Trp136Ser Uncertain significance Single submitter
- ATOSB p.Val409Met Uncertain significance Single submitter
- ATOSB p.Val47Ala Uncertain significance Single submitter
- ATOSB p.Val99Leu Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- ATOSB p.Arg263Gln Uncertain significance Single submitter
- ATOSB p.Arg263Trp Uncertain significance Single submitter
- ATOSB p.Arg265His Uncertain significance Single submitter
- ATOSB p.Arg314His Uncertain significance Single submitter
- ATOSB p.Arg315His Uncertain significance Single submitter
- ATOSB p.Arg325Trp Uncertain significance Single submitter
- ATOSB p.Arg346Cys Uncertain significance Single submitter
- ATOSB p.Arg358Gln Uncertain significance Single submitter
- ATOSB p.Arg360Cys Uncertain significance Single submitter
- ATOSB p.Arg68Leu Uncertain significance Single submitter
- ATOSB p.Glu471Lys Uncertain significance Single submitter
- ATOSB p.Glu521Lys Uncertain significance Single submitter
- ATOSB p.Gly40Trp Uncertain significance Single submitter
- ATOSB p.His223Tyr Uncertain significance Single submitter
- ATOSB p.His366Pro Uncertain significance Single submitter
- ATOSB p.Pro232Arg Uncertain significance Single submitter
- ATOSB p.Ser174Phe Uncertain significance Single submitter
- ATOSB p.Ser216Phe Uncertain significance Single submitter
- ATOSB p.Thr228Ile Uncertain significance Single submitter
- ATOSB p.Thr371Ala Uncertain significance Single submitter
- ATOSB p.Thr386Met Uncertain significance Single submitter
- ATOSB p.Val421Met Uncertain significance Single submitter
All ATOSB variants
Likely benign 4
- p.Arg121His Single submitter
- p.Gly304Ser Single submitter
- p.Pro107Leu Single submitter
- p.Val4Glu Single submitter
Uncertain significance 77
- p.Ala161Val Single submitter ⚠
- p.Ala194Thr Single submitter ⚠
- p.Ala220Thr Single submitter ⚠
- p.Ala27Ser Single submitter ⚠
- p.Ala6Val Single submitter ⚠
- p.Arg263Gln Single submitter ⚠
- p.Arg263Trp Single submitter ⚠
- p.Arg265His Single submitter ⚠
- p.Arg314His Single submitter ⚠
- p.Arg315His Single submitter ⚠
- p.Arg325Trp Single submitter ⚠
- p.Arg346Cys Single submitter ⚠
- p.Arg358Gln Single submitter ⚠
- p.Arg360Cys Single submitter ⚠
- p.Arg490Gln Single submitter ⚠
- p.Arg510Trp Single submitter ⚠
- p.Arg68Leu Single submitter ⚠
- p.Asp187Asn Single submitter ⚠
- p.Asp299Ala Single submitter ⚠
- p.Gln49His Single submitter ⚠
- p.Glu173Lys Single submitter ⚠
- p.Glu256Asp Single submitter ⚠
- p.Glu471Lys Single submitter ⚠
- p.Glu521Lys Single submitter ⚠
- p.Glu74Asp Single submitter ⚠
- p.Glu89Gln Single submitter ⚠
- p.Gly139Arg Single submitter ⚠
- p.Gly169Arg Single submitter ⚠
- p.Gly172Glu Single submitter ⚠
- p.Gly197Arg Single submitter ⚠
- p.Gly206Ser Single submitter ⚠
- p.Gly30Ala Single submitter ⚠
- p.Gly369Asp Single submitter ⚠
- p.Gly40Ala Single submitter ⚠
- p.Gly40Glu Single submitter ⚠
- p.Gly40Trp Single submitter ⚠
- p.Gly40Val Single submitter ⚠
- p.His156Pro Single submitter ⚠
- p.His223Tyr Single submitter ⚠
- p.His366Pro Single submitter ⚠
- p.His461Arg Single submitter ⚠
- p.His530Leu Single submitter ⚠
- p.Ile503Thr Single submitter ⚠
- p.Leu463Pro Single submitter ⚠
- p.Met34Thr Single submitter ⚠
- p.Met451Ile Single submitter ⚠
- p.Met456Lys Single submitter ⚠
- p.Pro143Ala Single submitter ⚠
- p.Pro143Leu Single submitter ⚠
- p.Pro143Thr Single submitter ⚠
- p.Pro144Leu Single submitter ⚠
- p.Pro14Leu Single submitter ⚠
- p.Pro18Ser Single submitter ⚠
- p.Pro21Leu Single submitter ⚠
- p.Pro232Arg Single submitter ⚠
- p.Pro262Ser Single submitter ⚠
- p.Pro293Ser Single submitter ⚠
- p.Pro333Ala Single submitter ⚠
- p.Pro333Ser Single submitter ⚠
- p.Pro538Arg Single submitter ⚠
- p.Pro8Leu Single submitter ⚠
- p.Pro93Ala Single submitter ⚠
- p.Ser174Phe Single submitter ⚠
- p.Ser216Phe Single submitter ⚠
- p.Ser319Arg Single submitter ⚠
- p.Ser323Arg Single submitter ⚠
- p.Ser332Thr Single submitter ⚠
- p.Thr185Ala Single submitter ⚠
- p.Thr228Ile Single submitter ⚠
- p.Thr347Ala Single submitter ⚠
- p.Thr371Ala Single submitter ⚠
- p.Thr386Met Single submitter ⚠
- p.Trp136Ser Single submitter ⚠
- p.Val409Met Single submitter ⚠
- p.Val421Met Single submitter ⚠
- p.Val47Ala Single submitter ⚠
- p.Val99Leu Single submitter ⚠