ATP5F1C — 38 ClinVar variants
All ClinVar germline ATP5F1C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
2 Likely benign · 36 Uncertain significance
Full ATP5F1C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ATP5F1C p.Ala12Val Uncertain significance Single submitter
- ATP5F1C p.Ala264Val Uncertain significance Single submitter
- ATP5F1C p.Ala52Val Uncertain significance Single submitter
- ATP5F1C p.Ala59Val Uncertain significance Single submitter
- ATP5F1C p.Ala75Val Uncertain significance Single submitter
- ATP5F1C p.Arg277Cys Uncertain significance Single submitter
- ATP5F1C p.Arg33Lys Uncertain significance Single submitter
- ATP5F1C p.Arg61Ser Uncertain significance Single submitter
- ATP5F1C p.Glu86Lys Uncertain significance Single submitter
- ATP5F1C p.Gly6Arg Uncertain significance Single submitter
- ATP5F1C p.Ile169Thr Uncertain significance Single submitter
- ATP5F1C p.Ile169Val Uncertain significance Single submitter
- ATP5F1C p.Leu15Ser Uncertain significance Single submitter
- ATP5F1C p.Met215Ile Uncertain significance Single submitter
- ATP5F1C p.Met215Val Uncertain significance Single submitter
- ATP5F1C p.Pro160Ala Uncertain significance Single submitter
- ATP5F1C p.Pro65Ser Uncertain significance Single submitter
- ATP5F1C p.Pro85Leu Uncertain significance Single submitter
- ATP5F1C p.Ser116Arg Uncertain significance Single submitter
- ATP5F1C p.Ser292Cys Uncertain significance Single submitter
- ATP5F1C p.Thr120Ala Uncertain significance Single submitter
- ATP5F1C p.Thr247Ile Uncertain significance Single submitter
- ATP5F1C p.Tyr196His Uncertain significance Single submitter
- ATP5F1C p.Tyr218Cys Uncertain significance Single submitter
- ATP5F1C p.Tyr239Cys Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- ATP5F1C p.Ala235Thr Uncertain significance Single submitter
- ATP5F1C p.Arg67Gln Uncertain significance Single submitter
- ATP5F1C p.Asp81Tyr Uncertain significance Single submitter
- ATP5F1C p.Lys126Glu Uncertain significance Single submitter
- ATP5F1C p.Thr274Ala Uncertain significance Single submitter
- ATP5F1C p.Val282Ala Uncertain significance Single submitter
All ATP5F1C variants
Likely benign 2
- p.Asn233Ser Single submitter
- p.Ile110Val Single submitter
Uncertain significance 36
- p.Ala12Val Single submitter ⚠
- p.Ala170Val Single submitter
- p.Ala235Thr Single submitter ⚠
- p.Ala264Val Single submitter ⚠
- p.Ala52Val Single submitter ⚠
- p.Ala59Val Single submitter ⚠
- p.Ala75Val Single submitter ⚠
- p.Arg277Cys Single submitter ⚠
- p.Arg33Lys Single submitter ⚠
- p.Arg61Ser Single submitter ⚠
- p.Arg67Gln Single submitter ⚠
- p.Asp81Tyr Single submitter ⚠
- p.Glu86Lys Single submitter ⚠
- p.Gly6Arg Single submitter ⚠
- p.Ile133Thr Single submitter
- p.Ile169Thr Single submitter ⚠
- p.Ile169Val Single submitter ⚠
- p.Ile221Thr Single submitter
- p.Leu15Ser Single submitter ⚠
- p.Lys126Glu Single submitter ⚠
- p.Lys49Arg Single submitter
- p.Met215Ile Single submitter ⚠
- p.Met215Val Single submitter ⚠
- p.Pro160Ala Single submitter ⚠
- p.Pro65Ser Single submitter ⚠
- p.Pro85Leu Single submitter ⚠
- p.Ser116Arg Single submitter ⚠
- p.Ser292Cys Single submitter ⚠
- p.Thr120Ala Single submitter ⚠
- p.Thr247Ile Single submitter ⚠
- p.Thr274Ala Single submitter ⚠
- p.Tyr196His Single submitter ⚠
- p.Tyr218Cys Single submitter ⚠
- p.Tyr239Cys Single submitter ⚠
- p.Val225Met Single submitter
- p.Val282Ala Single submitter ⚠