ATP5MF — 11 ClinVar variants
All ClinVar germline ATP5MF variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 11 flagged for review →
11 Uncertain significance
Full ATP5MF gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 11
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 4
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 7
The independent predictors disagree with each other — read with care.
- ATP5MF p.Arg50Trp Uncertain significance Single submitter
- ATP5MF p.Arg89Gln Uncertain significance Single submitter
- ATP5MF p.Asn57Ser Uncertain significance Single submitter
- ATP5MF p.Glu88Ala Uncertain significance Single submitter
- ATP5MF p.Lys83Arg Uncertain significance Single submitter
- ATP5MF p.Tyr52Cys Uncertain significance Single submitter
- ATP5MF p.Val74Met Uncertain significance Single submitter
All ATP5MF variants
Uncertain significance 11
- p.Arg50Trp Single submitter ⚠
- p.Arg89Gln Single submitter ⚠
- p.Asn57Ile Single submitter ⚠
- p.Asn57Ser Single submitter ⚠
- p.Cys7Phe Single submitter ⚠
- p.Glu88Ala Single submitter ⚠
- p.Lys83Arg Single submitter ⚠
- p.Met68Thr Single submitter ⚠
- p.Pro10Leu Single submitter ⚠
- p.Tyr52Cys Single submitter ⚠
- p.Val74Met Single submitter ⚠