ATRNL1 — 176 ClinVar variants
All ClinVar germline ATRNL1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 170 flagged for review →
3 Benign · 3 Likely benign · 170 Uncertain significance
Full ATRNL1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 170
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 111
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ATRNL1 p.Ala1303Ser Uncertain significance Single submitter
- ATRNL1 p.Ala25Ser Uncertain significance Single submitter
- ATRNL1 p.Ala462Asp Uncertain significance Single submitter
- ATRNL1 p.Ala559Ser Uncertain significance Single submitter
- ATRNL1 p.Ala563Gly Uncertain significance Single submitter
- ATRNL1 p.Ala662Ser Uncertain significance Single submitter
- ATRNL1 p.Ala883Val Uncertain significance Single submitter
- ATRNL1 p.Arg1271Gln Uncertain significance Single submitter
- ATRNL1 p.Arg1366Gln Uncertain significance Single submitter
- ATRNL1 p.Arg521Ile Uncertain significance Single submitter
- ATRNL1 p.Arg521Thr Uncertain significance Single submitter
- ATRNL1 p.Arg653Gly Uncertain significance Single submitter
- ATRNL1 p.Arg6Gly Uncertain significance Single submitter
- ATRNL1 p.Arg814Leu Uncertain significance Single submitter
- ATRNL1 p.Arg8Leu Uncertain significance Single submitter
- ATRNL1 p.Arg978Gln Uncertain significance Single submitter
- ATRNL1 p.Asn1152Asp Uncertain significance Single submitter
- ATRNL1 p.Asn1180Ser Uncertain significance Single submitter
- ATRNL1 p.Asn1225Ser Uncertain significance Single submitter
- ATRNL1 p.Asn344Ser Uncertain significance Single submitter
- ATRNL1 p.Asn507Ser Uncertain significance Single submitter
- ATRNL1 p.Asn574Asp Uncertain significance Single submitter
- ATRNL1 p.Asn574Ser Uncertain significance Single submitter
- ATRNL1 p.Asn626Asp Uncertain significance Single submitter
- ATRNL1 p.Asn649Asp Uncertain significance Single submitter
- ATRNL1 p.Asn778Ser Uncertain significance Single submitter
- ATRNL1 p.Asn842Ser Uncertain significance Single submitter
- ATRNL1 p.Asn880Thr Uncertain significance Single submitter
- ATRNL1 p.Asp1187Gly Uncertain significance Single submitter
- ATRNL1 p.Asp1283Ala Uncertain significance Single submitter
- ATRNL1 p.Asp151Asn Uncertain significance Single submitter
- ATRNL1 p.Asp279Glu Uncertain significance Single submitter
- ATRNL1 p.Asp38Ala Uncertain significance Single submitter
- ATRNL1 p.Asp688Glu Uncertain significance Single submitter
- ATRNL1 p.Cys280Arg Uncertain significance Single submitter
- ATRNL1 p.Cys716Tyr Uncertain significance Single submitter
- ATRNL1 p.Cys740Phe Uncertain significance Single submitter
- ATRNL1 p.Cys81Ser Uncertain significance Single submitter
- ATRNL1 p.Gln1087Arg Uncertain significance Single submitter
- ATRNL1 p.Gln1292His Uncertain significance Single submitter
- ATRNL1 p.Gln1352Glu Uncertain significance Single submitter
- ATRNL1 p.Glu1172Gly Uncertain significance Single submitter
- ATRNL1 p.Glu1287Gln Uncertain significance Single submitter
- ATRNL1 p.Glu1301Ala Uncertain significance Single submitter
- ATRNL1 p.Glu288Ala Uncertain significance Single submitter
- ATRNL1 p.Glu750Ala Uncertain significance Single submitter
- ATRNL1 p.Gly1046Ala Uncertain significance Single submitter
- ATRNL1 p.Gly125Ser Uncertain significance Single submitter
- ATRNL1 p.Gly1314Trp Uncertain significance Single submitter
- ATRNL1 p.Gly1337Ala Uncertain significance Single submitter
- ATRNL1 p.Gly18Arg Uncertain significance Single submitter
- ATRNL1 p.Gly254Ser Uncertain significance Single submitter
- ATRNL1 p.Gly26Ser Uncertain significance Single submitter
- ATRNL1 p.Gly404Arg Uncertain significance Single submitter
- ATRNL1 p.Gly466Asp Uncertain significance Single submitter
- ATRNL1 p.Gly486Arg Uncertain significance Single submitter
- ATRNL1 p.His391Arg Uncertain significance Single submitter
- ATRNL1 p.His405Arg Uncertain significance Single submitter
- ATRNL1 p.His470Tyr Uncertain significance Single submitter
- ATRNL1 p.His639Arg Uncertain significance Single submitter
- ATRNL1 p.His987Arg Uncertain significance Single submitter
- ATRNL1 p.Ile1307Val Uncertain significance Single submitter
- ATRNL1 p.Ile1343Val Uncertain significance Single submitter
- ATRNL1 p.Ile155Val Uncertain significance Single submitter
- ATRNL1 p.Ile167Leu Uncertain significance Single submitter
- ATRNL1 p.Ile569Val Uncertain significance Single submitter
- ATRNL1 p.Ile607Met Uncertain significance Single submitter
- ATRNL1 p.Ile631Val Uncertain significance Single submitter
- ATRNL1 p.Ile755Ser Uncertain significance Single submitter
- ATRNL1 p.Ile755Thr Uncertain significance Single submitter
- ATRNL1 p.Ile816Val Uncertain significance Single submitter
- ATRNL1 p.Leu334Pro Uncertain significance Single submitter
- ATRNL1 p.Leu421Met Uncertain significance Single submitter
- ATRNL1 p.Leu858Phe Uncertain significance Single submitter
- ATRNL1 p.Lys1179Arg Uncertain significance Single submitter
- ATRNL1 p.Lys1193Arg Uncertain significance Single submitter
- ATRNL1 p.Lys1193Glu Uncertain significance Single submitter
- ATRNL1 p.Lys460Asn Uncertain significance Single submitter
- ATRNL1 p.Lys61Gln Uncertain significance Single submitter
- ATRNL1 p.Lys632Gln Uncertain significance Single submitter
- ATRNL1 p.Lys790Glu Uncertain significance Single submitter
- ATRNL1 p.Met419Val Uncertain significance Single submitter
- ATRNL1 p.Met981Val Uncertain significance Single submitter
- ATRNL1 p.Met986Val Uncertain significance Single submitter
- ATRNL1 p.Pro1200Thr Uncertain significance Single submitter
- ATRNL1 p.Pro24Leu Uncertain significance Single submitter
- ATRNL1 p.Pro62Leu Uncertain significance Single submitter
- ATRNL1 p.Pro885Leu Uncertain significance Single submitter
- ATRNL1 p.Ser143Ile Uncertain significance Single submitter
- ATRNL1 p.Ser229Arg Uncertain significance Single submitter
- ATRNL1 p.Ser780Arg Uncertain significance Single submitter
- ATRNL1 p.Ser944Cys Uncertain significance Single submitter
- ATRNL1 p.Thr1203Ile Uncertain significance Single submitter
- ATRNL1 p.Thr660Ser Uncertain significance Single submitter
- ATRNL1 p.Thr9Ser Uncertain significance Single submitter
- ATRNL1 p.Trp1213Cys Uncertain significance Single submitter
- ATRNL1 p.Trp386Cys Uncertain significance Single submitter
- ATRNL1 p.Tyr115Phe Uncertain significance Single submitter
- ATRNL1 p.Tyr1191Asn Uncertain significance Single submitter
- ATRNL1 p.Tyr260Asp Uncertain significance Single submitter
- ATRNL1 p.Tyr356Asp Uncertain significance Single submitter
- ATRNL1 p.Tyr46Cys Uncertain significance Single submitter
- ATRNL1 p.Tyr495Cys Uncertain significance Single submitter
- ATRNL1 p.Tyr769Cys Uncertain significance Single submitter
- ATRNL1 p.Tyr820Cys Uncertain significance Single submitter
- ATRNL1 p.Tyr921Cys Uncertain significance Single submitter
- ATRNL1 p.Val1162Ile Uncertain significance Single submitter
- ATRNL1 p.Val1208Ile Uncertain significance Single submitter
- ATRNL1 p.Val181Ile Uncertain significance Single submitter
- ATRNL1 p.Val710Leu Uncertain significance Single submitter
- ATRNL1 p.Val807Glu Uncertain significance Single submitter
Predictors split 59
The independent predictors disagree with each other — read with care.
- ATRNL1 p.Ala1220Val Uncertain significance Single submitter
- ATRNL1 p.Ala1308Thr Uncertain significance Single submitter
- ATRNL1 p.Ala157Thr Uncertain significance Single submitter
- ATRNL1 p.Ala243Thr Uncertain significance Single submitter
- ATRNL1 p.Ala361Ser Uncertain significance Single submitter
- ATRNL1 p.Ala416Thr Uncertain significance Single submitter
- ATRNL1 p.Arg1263Gln Uncertain significance Single submitter
- ATRNL1 p.Arg1366Trp Uncertain significance Single submitter
- ATRNL1 p.Arg6Trp Uncertain significance Single submitter
- ATRNL1 p.Gln1056Glu Uncertain significance Single submitter
- ATRNL1 p.Gln1273Arg Uncertain significance Single submitter
- ATRNL1 p.Gln393His Uncertain significance Single submitter
- ATRNL1 p.Glu1265Lys Uncertain significance Single submitter
- ATRNL1 p.Glu505Gly Uncertain significance Single submitter
- ATRNL1 p.Glu516Lys Uncertain significance Single submitter
- ATRNL1 p.Glu566Val Uncertain significance Single submitter
- ATRNL1 p.Gly1171Glu Uncertain significance Single submitter
- ATRNL1 p.Gly1364Glu Uncertain significance Single submitter
- ATRNL1 p.Gly30Arg Uncertain significance Single submitter
- ATRNL1 p.Gly496Val Uncertain significance Single submitter
- ATRNL1 p.Gly591Arg Uncertain significance Single submitter
- ATRNL1 p.Gly822Glu Uncertain significance Single submitter
- ATRNL1 p.His218Arg Uncertain significance Single submitter
- ATRNL1 p.His448Tyr Uncertain significance Single submitter
- ATRNL1 p.Ile1202Thr Uncertain significance Single submitter
- ATRNL1 p.Ile607Ser Uncertain significance Single submitter
- ATRNL1 p.Leu1296Arg Uncertain significance Single submitter
- ATRNL1 p.Lys1179Asn Uncertain significance Single submitter
- ATRNL1 p.Lys1305Glu Uncertain significance Single submitter
- ATRNL1 p.Lys297Ile Uncertain significance Single submitter
- ATRNL1 p.Lys703Glu Uncertain significance Single submitter
- ATRNL1 p.Lys887Glu Uncertain significance Single submitter
- ATRNL1 p.Met533Val Uncertain significance Single submitter
- ATRNL1 p.Met826Val Uncertain significance Single submitter
- ATRNL1 p.Phe557Leu Uncertain significance Single submitter
- ATRNL1 p.Pro1335Thr Uncertain significance Single submitter
- ATRNL1 p.Pro1336Arg Uncertain significance Single submitter
- ATRNL1 p.Pro571Arg Uncertain significance Single submitter
- ATRNL1 p.Pro613Leu Uncertain significance Single submitter
- ATRNL1 p.Pro838Leu Uncertain significance Single submitter
- ATRNL1 p.Pro83Arg Uncertain significance Single submitter
- ATRNL1 p.Pro83Leu Uncertain significance Single submitter
- ATRNL1 p.Pro83Ser Uncertain significance Single submitter
- ATRNL1 p.Pro875Leu Uncertain significance Single submitter
- ATRNL1 p.Pro956Ser Uncertain significance Single submitter
- ATRNL1 p.Ser1093Pro Uncertain significance Single submitter
- ATRNL1 p.Ser210Phe Uncertain significance Single submitter
- ATRNL1 p.Ser274Asn Uncertain significance Single submitter
- ATRNL1 p.Ser675Gly Uncertain significance Single submitter
- ATRNL1 p.Ser696Asn Uncertain significance Single submitter
- ATRNL1 p.Ser910Arg Uncertain significance Single submitter
- ATRNL1 p.Ser939Phe Uncertain significance Single submitter
- ATRNL1 p.Thr1036Ala Uncertain significance Single submitter
- ATRNL1 p.Thr183Ile Uncertain significance Single submitter
- ATRNL1 p.Thr200Ser Uncertain significance Single submitter
- ATRNL1 p.Tyr260Ser Uncertain significance Single submitter
- ATRNL1 p.Tyr474Cys Uncertain significance Single submitter
- ATRNL1 p.Val1231Met Uncertain significance Single submitter
- ATRNL1 p.Val527Ala Uncertain significance Single submitter
All ATRNL1 variants
Benign 3
- p.Ile390Val Multiple submitters
- p.Ser989Asn Multiple submitters
- p.Thr1203= Multiple submitters
Likely benign 3
- p.Ala243= Single submitter
- p.Gln1087= Single submitter
- p.Val634Ile Single submitter
Uncertain significance 170
- p.Ala1220Val Single submitter ⚠
- p.Ala1303Ser Single submitter ⚠
- p.Ala1308Thr Single submitter ⚠
- p.Ala157Thr Single submitter ⚠
- p.Ala243Thr Single submitter ⚠
- p.Ala25Ser Single submitter ⚠
- p.Ala361Ser Single submitter ⚠
- p.Ala416Thr Single submitter ⚠
- p.Ala462Asp Single submitter ⚠
- p.Ala559Ser Single submitter ⚠
- p.Ala563Gly Single submitter ⚠
- p.Ala662Ser Single submitter ⚠
- p.Ala883Val Single submitter ⚠
- p.Arg1263Gln Single submitter ⚠
- p.Arg1271Gln Single submitter ⚠
- p.Arg1366Gln Single submitter ⚠
- p.Arg1366Trp Single submitter ⚠
- p.Arg521Ile Single submitter ⚠
- p.Arg521Thr Single submitter ⚠
- p.Arg653Gly Single submitter ⚠
- p.Arg6Gly Single submitter ⚠
- p.Arg6Trp Single submitter ⚠
- p.Arg814Leu Single submitter ⚠
- p.Arg8Leu Single submitter ⚠
- p.Arg978Gln Single submitter ⚠
- p.Asn1152Asp Single submitter ⚠
- p.Asn1180Ser Single submitter ⚠
- p.Asn1225Ser Single submitter ⚠
- p.Asn344Ser Single submitter ⚠
- p.Asn507Ser Single submitter ⚠
- p.Asn574Asp Single submitter ⚠
- p.Asn574Ser Single submitter ⚠
- p.Asn626Asp Single submitter ⚠
- p.Asn649Asp Single submitter ⚠
- p.Asn778Ser Single submitter ⚠
- p.Asn842Ser Single submitter ⚠
- p.Asn880Thr Single submitter ⚠
- p.Asp1187Gly Single submitter ⚠
- p.Asp1283Ala Single submitter ⚠
- p.Asp151Asn Single submitter ⚠
- p.Asp279Glu Single submitter ⚠
- p.Asp38Ala Single submitter ⚠
- p.Asp688Glu Single submitter ⚠
- p.Cys280Arg Single submitter ⚠
- p.Cys716Tyr Single submitter ⚠
- p.Cys740Phe Single submitter ⚠
- p.Cys81Ser Single submitter ⚠
- p.Gln1056Glu Single submitter ⚠
- p.Gln1087Arg Single submitter ⚠
- p.Gln1273Arg Single submitter ⚠
- p.Gln1292His Single submitter ⚠
- p.Gln1352Glu Single submitter ⚠
- p.Gln393His Single submitter ⚠
- p.Glu1172Gly Single submitter ⚠
- p.Glu1265Lys Single submitter ⚠
- p.Glu1287Gln Single submitter ⚠
- p.Glu1301Ala Single submitter ⚠
- p.Glu288Ala Single submitter ⚠
- p.Glu505Gly Single submitter ⚠
- p.Glu516Lys Single submitter ⚠
- p.Glu566Val Single submitter ⚠
- p.Glu750Ala Single submitter ⚠
- p.Gly1046Ala Single submitter ⚠
- p.Gly1171Glu Single submitter ⚠
- p.Gly125Ser Single submitter ⚠
- p.Gly1314Trp Single submitter ⚠
- p.Gly1337Ala Single submitter ⚠
- p.Gly1364Glu Single submitter ⚠
- p.Gly18Arg Single submitter ⚠
- p.Gly254Ser Single submitter ⚠
- p.Gly26Ser Single submitter ⚠
- p.Gly30Arg Single submitter ⚠
- p.Gly404Arg Single submitter ⚠
- p.Gly466Asp Single submitter ⚠
- p.Gly486Arg Single submitter ⚠
- p.Gly496Val Single submitter ⚠
- p.Gly591Arg Single submitter ⚠
- p.Gly822Glu Single submitter ⚠
- p.His218Arg Single submitter ⚠
- p.His391Arg Single submitter ⚠
- p.His405Arg Single submitter ⚠
- p.His448Tyr Single submitter ⚠
- p.His470Tyr Single submitter ⚠
- p.His639Arg Single submitter ⚠
- p.His987Arg Single submitter ⚠
- p.Ile1202Thr Single submitter ⚠
- p.Ile1307Val Single submitter ⚠
- p.Ile1343Val Single submitter ⚠
- p.Ile155Val Single submitter ⚠
- p.Ile167Leu Single submitter ⚠
- p.Ile569Val Single submitter ⚠
- p.Ile607Met Single submitter ⚠
- p.Ile607Ser Single submitter ⚠
- p.Ile631Val Single submitter ⚠
- p.Ile755Ser Single submitter ⚠
- p.Ile755Thr Single submitter ⚠
- p.Ile816Val Single submitter ⚠
- p.Leu1296Arg Single submitter ⚠
- p.Leu334Pro Single submitter ⚠
- p.Leu421Met Single submitter ⚠
- p.Leu858Phe Single submitter ⚠
- p.Lys1179Arg Single submitter ⚠
- p.Lys1179Asn Single submitter ⚠
- p.Lys1193Arg Single submitter ⚠
- p.Lys1193Glu Single submitter ⚠
- p.Lys1305Glu Single submitter ⚠
- p.Lys297Ile Single submitter ⚠
- p.Lys460Asn Single submitter ⚠
- p.Lys61Gln Single submitter ⚠
- p.Lys632Gln Single submitter ⚠
- p.Lys703Glu Single submitter ⚠
- p.Lys790Glu Single submitter ⚠
- p.Lys887Glu Single submitter ⚠
- p.Met419Val Single submitter ⚠
- p.Met533Val Single submitter ⚠
- p.Met826Val Single submitter ⚠
- p.Met981Val Single submitter ⚠
- p.Met986Val Single submitter ⚠
- p.Phe557Leu Single submitter ⚠
- p.Pro1200Thr Single submitter ⚠
- p.Pro1335Thr Single submitter ⚠
- p.Pro1336Arg Single submitter ⚠
- p.Pro24Leu Single submitter ⚠
- p.Pro571Arg Single submitter ⚠
- p.Pro613Leu Single submitter ⚠
- p.Pro62Leu Single submitter ⚠
- p.Pro838Leu Single submitter ⚠
- p.Pro83Arg Single submitter ⚠
- p.Pro83Leu Single submitter ⚠
- p.Pro83Ser Single submitter ⚠
- p.Pro875Leu Single submitter ⚠
- p.Pro885Leu Single submitter ⚠
- p.Pro956Ser Single submitter ⚠
- p.Ser1093Pro Single submitter ⚠
- p.Ser143Ile Single submitter ⚠
- p.Ser210Phe Single submitter ⚠
- p.Ser229Arg Single submitter ⚠
- p.Ser274Asn Single submitter ⚠
- p.Ser675Gly Single submitter ⚠
- p.Ser696Asn Single submitter ⚠
- p.Ser780Arg Single submitter ⚠
- p.Ser910Arg Single submitter ⚠
- p.Ser939Phe Single submitter ⚠
- p.Ser944Cys Single submitter ⚠
- p.Thr1036Ala Single submitter ⚠
- p.Thr1203Ile Single submitter ⚠
- p.Thr183Ile Single submitter ⚠
- p.Thr200Ser Single submitter ⚠
- p.Thr660Ser Single submitter ⚠
- p.Thr9Ser Single submitter ⚠
- p.Trp1213Cys Single submitter ⚠
- p.Trp386Cys Single submitter ⚠
- p.Tyr115Phe Single submitter ⚠
- p.Tyr1191Asn Single submitter ⚠
- p.Tyr260Asp Single submitter ⚠
- p.Tyr260Ser Single submitter ⚠
- p.Tyr356Asp Single submitter ⚠
- p.Tyr46Cys Single submitter ⚠
- p.Tyr474Cys Single submitter ⚠
- p.Tyr495Cys Single submitter ⚠
- p.Tyr769Cys Single submitter ⚠
- p.Tyr820Cys Single submitter ⚠
- p.Tyr921Cys Single submitter ⚠
- p.Val1162Ile Single submitter ⚠
- p.Val1208Ile Single submitter ⚠
- p.Val1231Met Single submitter ⚠
- p.Val181Ile Single submitter ⚠
- p.Val527Ala Single submitter ⚠
- p.Val710Leu Single submitter ⚠
- p.Val807Glu Single submitter ⚠