AUNIP — 49 ClinVar variants
All ClinVar germline AUNIP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →
2 Likely benign · 47 Uncertain significance
Full AUNIP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 47
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- AUNIP p.Ala10Ser Uncertain significance Single submitter
- AUNIP p.Ala326Val Uncertain significance Single submitter
- AUNIP p.Ala55Val Uncertain significance Single submitter
- AUNIP p.Arg144Lys Uncertain significance Single submitter
- AUNIP p.Arg233Ile Uncertain significance Single submitter
- AUNIP p.Arg266His Uncertain significance Single submitter
- AUNIP p.Asn240Lys Uncertain significance Single submitter
- AUNIP p.Asn258Asp Uncertain significance Single submitter
- AUNIP p.Asp166Gly Uncertain significance Single submitter
- AUNIP p.Asp186Glu Uncertain significance Single submitter
- AUNIP p.Asp280Asn Uncertain significance Single submitter
- AUNIP p.Asp280Glu Uncertain significance Single submitter
- AUNIP p.Asp346Glu Uncertain significance Single submitter
- AUNIP p.Asp346Gly Uncertain significance Single submitter
- AUNIP p.Gln356His Uncertain significance Single submitter
- AUNIP p.Gln91His Uncertain significance Single submitter
- AUNIP p.Glu177Lys Uncertain significance Single submitter
- AUNIP p.Glu180Gly Uncertain significance Single submitter
- AUNIP p.Glu260Gly Uncertain significance Single submitter
- AUNIP p.Gly256Glu Uncertain significance Single submitter
- AUNIP p.Gly5Val Uncertain significance Single submitter
- AUNIP p.Gly78Asp Uncertain significance Single submitter
- AUNIP p.Ile48Thr Uncertain significance Single submitter
- AUNIP p.Lys188Arg Uncertain significance Single submitter
- AUNIP p.Lys45Asn Uncertain significance Single submitter
- AUNIP p.Lys94Arg Uncertain significance Single submitter
- AUNIP p.Pro134Thr Uncertain significance Single submitter
- AUNIP p.Pro218Leu Uncertain significance Single submitter
- AUNIP p.Pro319Leu Uncertain significance Single submitter
- AUNIP p.Pro319Thr Uncertain significance Single submitter
- AUNIP p.Ser181Asn Uncertain significance Single submitter
- AUNIP p.Ser90Asn Uncertain significance Single submitter
- AUNIP p.Thr160Asn Uncertain significance Single submitter
- AUNIP p.Trp254Ser Uncertain significance Single submitter
- AUNIP p.Tyr49Cys Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- AUNIP p.Arg296Trp Uncertain significance Single submitter
- AUNIP p.Asn47Tyr Uncertain significance Single submitter
- AUNIP p.Asp178Tyr Uncertain significance Single submitter
- AUNIP p.Asp346Asn Uncertain significance Single submitter
- AUNIP p.Leu106Met Uncertain significance Single submitter
- AUNIP p.Leu155Trp Uncertain significance Single submitter
- AUNIP p.Lys24Gln Uncertain significance Single submitter
- AUNIP p.Phe68Ile Uncertain significance Single submitter
- AUNIP p.Ser253Phe Uncertain significance Single submitter
- AUNIP p.Ser285Arg Uncertain significance Single submitter
- AUNIP p.Ser64Gly Uncertain significance Single submitter
- AUNIP p.Ser67Cys Uncertain significance Single submitter
All AUNIP variants
Likely benign 2
- p.Glu260fs Single submitter
- p.Thr302Ser Single submitter
Uncertain significance 47
- p.Ala10Ser Single submitter ⚠
- p.Ala326Val Single submitter ⚠
- p.Ala55Val Single submitter ⚠
- p.Arg144Lys Single submitter ⚠
- p.Arg233Ile Single submitter ⚠
- p.Arg266His Single submitter ⚠
- p.Arg296Trp Single submitter ⚠
- p.Asn240Lys Single submitter ⚠
- p.Asn258Asp Single submitter ⚠
- p.Asn47Tyr Single submitter ⚠
- p.Asp166Gly Single submitter ⚠
- p.Asp178Tyr Single submitter ⚠
- p.Asp186Glu Single submitter ⚠
- p.Asp280Asn Single submitter ⚠
- p.Asp280Glu Single submitter ⚠
- p.Asp346Asn Single submitter ⚠
- p.Asp346Glu Single submitter ⚠
- p.Asp346Gly Single submitter ⚠
- p.Gln356His Single submitter ⚠
- p.Gln91His Single submitter ⚠
- p.Glu177Lys Single submitter ⚠
- p.Glu180Gly Single submitter ⚠
- p.Glu260Gly Single submitter ⚠
- p.Gly256Glu Single submitter ⚠
- p.Gly5Val Single submitter ⚠
- p.Gly78Asp Single submitter ⚠
- p.Ile48Thr Single submitter ⚠
- p.Leu106Met Single submitter ⚠
- p.Leu155Trp Single submitter ⚠
- p.Lys188Arg Single submitter ⚠
- p.Lys24Gln Single submitter ⚠
- p.Lys45Asn Single submitter ⚠
- p.Lys94Arg Single submitter ⚠
- p.Phe68Ile Single submitter ⚠
- p.Pro134Thr Single submitter ⚠
- p.Pro218Leu Single submitter ⚠
- p.Pro319Leu Single submitter ⚠
- p.Pro319Thr Single submitter ⚠
- p.Ser181Asn Single submitter ⚠
- p.Ser253Phe Single submitter ⚠
- p.Ser285Arg Single submitter ⚠
- p.Ser64Gly Single submitter ⚠
- p.Ser67Cys Single submitter ⚠
- p.Ser90Asn Single submitter ⚠
- p.Thr160Asn Single submitter ⚠
- p.Trp254Ser Single submitter ⚠
- p.Tyr49Cys Single submitter ⚠