AURKAIP1 — 27 ClinVar variants
All ClinVar germline AURKAIP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 27 flagged for review →
1 Likely benign · 26 Uncertain significance
Full AURKAIP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 27
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- AURKAIP1 p.Ala56Ser Uncertain significance Single submitter
- AURKAIP1 p.Ala92Thr Uncertain significance Single submitter
- AURKAIP1 p.Ala96Val Uncertain significance Single submitter
- AURKAIP1 p.Arg67Gly Uncertain significance Single submitter
- AURKAIP1 p.Cys34Phe Uncertain significance Single submitter
- AURKAIP1 p.Gln114His Uncertain significance Single submitter
- AURKAIP1 p.Gln57His Uncertain significance Single submitter
- AURKAIP1 p.Glu59Lys Uncertain significance Single submitter
- AURKAIP1 p.Ile108Met Uncertain significance Single submitter
- AURKAIP1 p.Ile176Met Uncertain significance Single submitter
- AURKAIP1 p.Pro192Ser Uncertain significance Single submitter
- AURKAIP1 p.Pro22Leu Uncertain significance Single submitter
- AURKAIP1 p.Pro24Ser Uncertain significance Single submitter
- AURKAIP1 p.Pro36Thr Uncertain significance Single submitter
- AURKAIP1 p.Ser106Thr Uncertain significance Single submitter
- AURKAIP1 p.Thr79Met Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- AURKAIP1 p.Ala13Thr Uncertain significance Single submitter
- AURKAIP1 p.Arg136Gln Uncertain significance Single submitter
- AURKAIP1 p.Arg151Gly Uncertain significance Single submitter
- AURKAIP1 p.Arg164Gly Uncertain significance Single submitter
- AURKAIP1 p.Arg86Lys Uncertain significance Single submitter
- AURKAIP1 p.Gln158Glu Uncertain significance Single submitter
- AURKAIP1 p.Leu78Phe Uncertain significance Single submitter
- AURKAIP1 p.Lys193Arg Uncertain significance Single submitter
- AURKAIP1 p.Lys193Asn Likely benign Single submitter
- AURKAIP1 p.Pro123Leu Uncertain significance Single submitter
- AURKAIP1 p.Pro66Leu Uncertain significance Single submitter
All AURKAIP1 variants
Likely benign 1
- p.Lys193Asn Single submitter ⚠
Uncertain significance 26
- p.Ala13Thr Single submitter ⚠
- p.Ala56Ser Single submitter ⚠
- p.Ala92Thr Single submitter ⚠
- p.Ala96Val Single submitter ⚠
- p.Arg136Gln Single submitter ⚠
- p.Arg151Gly Single submitter ⚠
- p.Arg164Gly Single submitter ⚠
- p.Arg67Gly Single submitter ⚠
- p.Arg86Lys Single submitter ⚠
- p.Cys34Phe Single submitter ⚠
- p.Gln114His Single submitter ⚠
- p.Gln158Glu Single submitter ⚠
- p.Gln57His Single submitter ⚠
- p.Glu59Lys Single submitter ⚠
- p.Ile108Met Single submitter ⚠
- p.Ile176Met Single submitter ⚠
- p.Leu78Phe Single submitter ⚠
- p.Lys193Arg Single submitter ⚠
- p.Pro123Leu Single submitter ⚠
- p.Pro192Ser Single submitter ⚠
- p.Pro22Leu Single submitter ⚠
- p.Pro24Ser Single submitter ⚠
- p.Pro36Thr Single submitter ⚠
- p.Pro66Leu Single submitter ⚠
- p.Ser106Thr Single submitter ⚠
- p.Thr79Met Single submitter ⚠