AXDND1 — 144 ClinVar variants
All ClinVar germline AXDND1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 135 flagged for review →
1 Likely pathogenic · 10 Likely benign · 133 Uncertain significance
Full AXDND1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 135
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 90
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- AXDND1 p.Ala71Thr Uncertain significance Multiple submitters
- AXDND1 p.Ala395Val Uncertain significance Single submitter
- AXDND1 p.Ala670Thr Uncertain significance Single submitter
- AXDND1 p.Ala774Val Uncertain significance Single submitter
-
AXDND1 p.Ala868Thr
Uncertain significance
Single submitter
male infertility
- AXDND1 p.Arg152Cys Uncertain significance Single submitter
- AXDND1 p.Arg218Ser Uncertain significance Single submitter
- AXDND1 p.Arg300Gln Uncertain significance Single submitter
- AXDND1 p.Arg341Gln Uncertain significance Single submitter
- AXDND1 p.Arg383Ile Uncertain significance Single submitter
- AXDND1 p.Arg562Trp Uncertain significance Single submitter
- AXDND1 p.Arg883Gln Uncertain significance Single submitter
- AXDND1 p.Arg883Gly Uncertain significance Single submitter
- AXDND1 p.Asn561His Uncertain significance Single submitter
- AXDND1 p.Asn711Ser Uncertain significance Single submitter
- AXDND1 p.Asn72Ser Uncertain significance Single submitter
- AXDND1 p.Asp445Gly Uncertain significance Single submitter
- AXDND1 p.Asp598Gly Uncertain significance Single submitter
- AXDND1 p.Asp722Asn Uncertain significance Single submitter
- AXDND1 p.Asp98His Uncertain significance Single submitter
- AXDND1 p.Cys808Phe Uncertain significance Single submitter
- AXDND1 p.Gln457Lys Uncertain significance Single submitter
- AXDND1 p.Gln492Glu Uncertain significance Single submitter
- AXDND1 p.Gln585Lys Uncertain significance Single submitter
- AXDND1 p.Gln658His Uncertain significance Single submitter
- AXDND1 p.Gln757Glu Uncertain significance Single submitter
- AXDND1 p.Gln941Glu Uncertain significance Single submitter
- AXDND1 p.Glu190Gly Uncertain significance Single submitter
- AXDND1 p.Glu233Lys Uncertain significance Single submitter
- AXDND1 p.Glu373Lys Uncertain significance Single submitter
- AXDND1 p.Glu623Asp Uncertain significance Single submitter
- AXDND1 p.Glu700Asp Uncertain significance Single submitter
- AXDND1 p.Glu852Lys Uncertain significance Single submitter
- AXDND1 p.Glu853Lys Uncertain significance Single submitter
- AXDND1 p.Glu930Asp Uncertain significance Single submitter
- AXDND1 p.Glu994Gln Uncertain significance Single submitter
- AXDND1 p.Gly684Asp Uncertain significance Single submitter
- AXDND1 p.Gly690Ser Uncertain significance Single submitter
- AXDND1 p.Gly912Ser Uncertain significance Single submitter
- AXDND1 p.His103Gln Uncertain significance Single submitter
- AXDND1 p.His157Arg Uncertain significance Single submitter
- AXDND1 p.His376Asn Uncertain significance Single submitter
- AXDND1 p.Ile180Val Uncertain significance Single submitter
- AXDND1 p.Ile254Thr Uncertain significance Single submitter
- AXDND1 p.Ile254Val Uncertain significance Single submitter
- AXDND1 p.Ile439Val Uncertain significance Single submitter
- AXDND1 p.Ile660Met Uncertain significance Single submitter
- AXDND1 p.Leu11Pro Uncertain significance Single submitter
- AXDND1 p.Leu150Val Uncertain significance Single submitter
- AXDND1 p.Leu295Phe Uncertain significance Single submitter
- AXDND1 p.Leu34Val Uncertain significance Single submitter
- AXDND1 p.Leu775Val Uncertain significance Single submitter
- AXDND1 p.Leu93Pro Uncertain significance Single submitter
- AXDND1 p.Lys28Arg Uncertain significance Single submitter
- AXDND1 p.Lys367Asn Uncertain significance Single submitter
- AXDND1 p.Lys490Arg Uncertain significance Single submitter
- AXDND1 p.Lys527Asn Uncertain significance Single submitter
- AXDND1 p.Lys61Asn Uncertain significance Single submitter
- AXDND1 p.Lys643Arg Uncertain significance Single submitter
-
AXDND1 p.Lys817Asn
Uncertain significance
Single submitter
male infertility
- AXDND1 p.Lys84Arg Uncertain significance Single submitter
- AXDND1 p.Lys894Asn Uncertain significance Single submitter
- AXDND1 p.Lys972Asn Uncertain significance Single submitter
- AXDND1 p.Met231Thr Uncertain significance Single submitter
- AXDND1 p.Met43Leu Uncertain significance Single submitter
- AXDND1 p.Met43Val Uncertain significance Single submitter
- AXDND1 p.Met773Ile Uncertain significance Single submitter
- AXDND1 p.Met968Leu Uncertain significance Single submitter
- AXDND1 p.Pro147Ala Uncertain significance Single submitter
- AXDND1 p.Pro148Gln Uncertain significance Single submitter
- AXDND1 p.Pro166Ser Uncertain significance Single submitter
- AXDND1 p.Pro89Ser Uncertain significance Single submitter
- AXDND1 p.Pro94Arg Uncertain significance Single submitter
- AXDND1 p.Ser15Thr Uncertain significance Single submitter
- AXDND1 p.Ser478Asn Uncertain significance Single submitter
- AXDND1 p.Thr230Ala Uncertain significance Single submitter
- AXDND1 p.Thr260Ile Uncertain significance Single submitter
- AXDND1 p.Thr627Ala Uncertain significance Single submitter
- AXDND1 p.Thr68Ile Uncertain significance Single submitter
- AXDND1 p.Thr6Ala Uncertain significance Single submitter
- AXDND1 p.Thr771Ile Uncertain significance Single submitter
- AXDND1 p.Trp552Gly Uncertain significance Single submitter
- AXDND1 p.Tyr135Cys Uncertain significance Single submitter
- AXDND1 p.Tyr324Cys Uncertain significance Single submitter
- AXDND1 p.Tyr379Cys Uncertain significance Single submitter
- AXDND1 p.Tyr405Cys Uncertain significance Single submitter
- AXDND1 p.Tyr69His Uncertain significance Single submitter
- AXDND1 p.Val237Glu Uncertain significance Single submitter
- AXDND1 p.Val273Phe Uncertain significance Single submitter
- AXDND1 p.Val411Met Uncertain significance Single submitter
Predictors split 45
The independent predictors disagree with each other — read with care.
-
AXDND1 p.Asp948Gly
Uncertain significance
Multiple submitters
male infertility
- AXDND1 p.Ala748Val Uncertain significance Single submitter
- AXDND1 p.Arg290Ser Uncertain significance Single submitter
- AXDND1 p.Arg341Pro Uncertain significance Single submitter
- AXDND1 p.Arg594Lys Uncertain significance Single submitter
- AXDND1 p.Asn599Ser Uncertain significance Single submitter
- AXDND1 p.Asn960His Uncertain significance Single submitter
- AXDND1 p.Asp344Asn Uncertain significance Single submitter
- AXDND1 p.Gln259Lys Uncertain significance Single submitter
- AXDND1 p.Glu384Gly Likely benign Single submitter
- AXDND1 p.Glu387Val Uncertain significance Single submitter
- AXDND1 p.Glu791Gly Uncertain significance Single submitter
- AXDND1 p.Glu866Asp Uncertain significance Single submitter
- AXDND1 p.Glu934Gly Uncertain significance Single submitter
- AXDND1 p.Glu976Gly Likely benign Single submitter
- AXDND1 p.Glu976Val Uncertain significance Single submitter
- AXDND1 p.Gly188Cys Uncertain significance Single submitter
- AXDND1 p.Gly600Asp Uncertain significance Single submitter
- AXDND1 p.His343Arg Uncertain significance Single submitter
- AXDND1 p.His702Tyr Uncertain significance Single submitter
- AXDND1 p.Ile127Thr Uncertain significance Single submitter
- AXDND1 p.Ile559Val Uncertain significance Single submitter
- AXDND1 p.Ile882Thr Uncertain significance Single submitter
- AXDND1 p.Leu251Val Uncertain significance Single submitter
-
AXDND1 p.Leu536Gln
Uncertain significance
Single submitter
male infertility
- AXDND1 p.Leu668Phe Uncertain significance Single submitter
- AXDND1 p.Leu762Ser Uncertain significance Single submitter
- AXDND1 p.Leu963Val Uncertain significance Single submitter
- AXDND1 p.Leu966Ser Uncertain significance Single submitter
- AXDND1 p.Lys465Arg Uncertain significance Single submitter
- AXDND1 p.Lys527Glu Uncertain significance Single submitter
- AXDND1 p.Lys945Glu Uncertain significance Single submitter
- AXDND1 p.Met231Ile Uncertain significance Single submitter
- AXDND1 p.Phe305Leu Uncertain significance Single submitter
- AXDND1 p.Pro606Leu Uncertain significance Single submitter
- AXDND1 p.Pro606Ser Uncertain significance Single submitter
- AXDND1 p.Ser13Cys Uncertain significance Single submitter
- AXDND1 p.Ser476Cys Uncertain significance Single submitter
- AXDND1 p.Thr246Arg Uncertain significance Single submitter
- AXDND1 p.Thr404Ile Uncertain significance Single submitter
- AXDND1 p.Thr956Asn Uncertain significance Single submitter
- AXDND1 p.Thr969Pro Uncertain significance Single submitter
- AXDND1 p.Tyr379His Uncertain significance Single submitter
- AXDND1 p.Tyr758Cys Uncertain significance Single submitter
- AXDND1 p.Val275Ala Uncertain significance Single submitter
All AXDND1 variants
Likely pathogenic 1
- p.Arg313Ter Single submitter Non-obstructive azoospermia
Likely benign 10
- p.Arg152His Single submitter
- p.Arg46His Single submitter
- p.Arg828Gln Single submitter
- p.Asn1003Asp Single submitter
- p.Glu384Gly Single submitter ⚠
- p.Glu845Lys Single submitter
- p.Glu976Gly Single submitter ⚠
- p.Ile265Val Single submitter
- p.Ile371Met Single submitter
- p.Pro1008Leu Single submitter
Uncertain significance 133
- p.Ala71Thr Multiple submitters ⚠
- p.Asp948Gly Multiple submitters male infertility ⚠
- p.Ala395Val Single submitter ⚠
- p.Ala670Thr Single submitter ⚠
- p.Ala748Val Single submitter ⚠
- p.Ala774Val Single submitter ⚠
- p.Ala868Thr Single submitter male infertility ⚠
- p.Arg152Cys Single submitter ⚠
- p.Arg218Ser Single submitter ⚠
- p.Arg290Ser Single submitter ⚠
- p.Arg300Gln Single submitter ⚠
- p.Arg341Gln Single submitter ⚠
- p.Arg341Pro Single submitter ⚠
- p.Arg383Ile Single submitter ⚠
- p.Arg562Trp Single submitter ⚠
- p.Arg594Lys Single submitter ⚠
- p.Arg883Gln Single submitter ⚠
- p.Arg883Gly Single submitter ⚠
- p.Asn561His Single submitter ⚠
- p.Asn599Ser Single submitter ⚠
- p.Asn711Ser Single submitter ⚠
- p.Asn72Ser Single submitter ⚠
- p.Asn960His Single submitter ⚠
- p.Asp344Asn Single submitter ⚠
- p.Asp445Gly Single submitter ⚠
- p.Asp598Gly Single submitter ⚠
- p.Asp722Asn Single submitter ⚠
- p.Asp98His Single submitter ⚠
- p.Cys808Phe Single submitter ⚠
- p.Gln259Lys Single submitter ⚠
- p.Gln457Lys Single submitter ⚠
- p.Gln492Glu Single submitter ⚠
- p.Gln585Lys Single submitter ⚠
- p.Gln658His Single submitter ⚠
- p.Gln757Glu Single submitter ⚠
- p.Gln941Glu Single submitter ⚠
- p.Glu190Gly Single submitter ⚠
- p.Glu233Lys Single submitter ⚠
- p.Glu373Lys Single submitter ⚠
- p.Glu387Val Single submitter ⚠
- p.Glu623Asp Single submitter ⚠
- p.Glu700Asp Single submitter ⚠
- p.Glu791Gly Single submitter ⚠
- p.Glu852Lys Single submitter ⚠
- p.Glu853Lys Single submitter ⚠
- p.Glu866Asp Single submitter ⚠
- p.Glu930Asp Single submitter ⚠
- p.Glu934Gly Single submitter ⚠
- p.Glu976Val Single submitter ⚠
- p.Glu994Gln Single submitter ⚠
- p.Gly188Cys Single submitter ⚠
- p.Gly600Asp Single submitter ⚠
- p.Gly684Asp Single submitter ⚠
- p.Gly690Ser Single submitter ⚠
- p.Gly912Ser Single submitter ⚠
- p.His103Gln Single submitter ⚠
- p.His157Arg Single submitter ⚠
- p.His343Arg Single submitter ⚠
- p.His376Asn Single submitter ⚠
- p.His702Tyr Single submitter ⚠
- p.Ile127Thr Single submitter ⚠
- p.Ile180Val Single submitter ⚠
- p.Ile254Thr Single submitter ⚠
- p.Ile254Val Single submitter ⚠
- p.Ile439Val Single submitter ⚠
- p.Ile559Val Single submitter ⚠
- p.Ile660Met Single submitter ⚠
- p.Ile882Thr Single submitter ⚠
- p.Leu11Pro Single submitter ⚠
- p.Leu150Val Single submitter ⚠
- p.Leu251Val Single submitter ⚠
- p.Leu295Phe Single submitter ⚠
- p.Leu34Val Single submitter ⚠
- p.Leu536Gln Single submitter male infertility ⚠
- p.Leu668Phe Single submitter ⚠
- p.Leu762Ser Single submitter ⚠
- p.Leu775Val Single submitter ⚠
- p.Leu93Pro Single submitter ⚠
- p.Leu963Val Single submitter ⚠
- p.Leu966Ser Single submitter ⚠
- p.Lys28Arg Single submitter ⚠
- p.Lys367Asn Single submitter ⚠
- p.Lys465Arg Single submitter ⚠
- p.Lys490Arg Single submitter ⚠
- p.Lys527Asn Single submitter ⚠
- p.Lys527Glu Single submitter ⚠
- p.Lys61Asn Single submitter ⚠
- p.Lys643Arg Single submitter ⚠
- p.Lys817Asn Single submitter male infertility ⚠
- p.Lys84Arg Single submitter ⚠
- p.Lys894Asn Single submitter ⚠
- p.Lys945Glu Single submitter ⚠
- p.Lys972Asn Single submitter ⚠
- p.Met231Ile Single submitter ⚠
- p.Met231Thr Single submitter ⚠
- p.Met43Leu Single submitter ⚠
- p.Met43Val Single submitter ⚠
- p.Met773Ile Single submitter ⚠
- p.Met968Leu Single submitter ⚠
- p.Phe305Leu Single submitter ⚠
- p.Pro147Ala Single submitter ⚠
- p.Pro148Gln Single submitter ⚠
- p.Pro166Ser Single submitter ⚠
- p.Pro606Leu Single submitter ⚠
- p.Pro606Ser Single submitter ⚠
- p.Pro89Ser Single submitter ⚠
- p.Pro94Arg Single submitter ⚠
- p.Ser13Cys Single submitter ⚠
- p.Ser15Thr Single submitter ⚠
- p.Ser476Cys Single submitter ⚠
- p.Ser478Asn Single submitter ⚠
- p.Thr230Ala Single submitter ⚠
- p.Thr246Arg Single submitter ⚠
- p.Thr260Ile Single submitter ⚠
- p.Thr404Ile Single submitter ⚠
- p.Thr627Ala Single submitter ⚠
- p.Thr68Ile Single submitter ⚠
- p.Thr6Ala Single submitter ⚠
- p.Thr771Ile Single submitter ⚠
- p.Thr956Asn Single submitter ⚠
- p.Thr969Pro Single submitter ⚠
- p.Trp552Gly Single submitter ⚠
- p.Tyr135Cys Single submitter ⚠
- p.Tyr324Cys Single submitter ⚠
- p.Tyr379Cys Single submitter ⚠
- p.Tyr379His Single submitter ⚠
- p.Tyr405Cys Single submitter ⚠
- p.Tyr69His Single submitter ⚠
- p.Tyr758Cys Single submitter ⚠
- p.Val237Glu Single submitter ⚠
- p.Val273Phe Single submitter ⚠
- p.Val275Ala Single submitter ⚠
- p.Val411Met Single submitter ⚠