BAG4 — 67 ClinVar variants
All ClinVar germline BAG4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 66 flagged for review →
2 Likely benign · 65 Uncertain significance
Full BAG4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 66
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 41
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BAG4 p.Ala107Val Uncertain significance Single submitter
- BAG4 p.Ala157Val Uncertain significance Single submitter
- BAG4 p.Ala248Thr Uncertain significance Single submitter
- BAG4 p.Ala447Val Uncertain significance Single submitter
- BAG4 p.Arg185His Uncertain significance Single submitter
- BAG4 p.Arg40Leu Uncertain significance Single submitter
- BAG4 p.Arg51Gln Uncertain significance Single submitter
- BAG4 p.Arg84Gln Uncertain significance Single submitter
- BAG4 p.Asn350Ser Uncertain significance Single submitter
- BAG4 p.Asp297Glu Uncertain significance Single submitter
- BAG4 p.Asp330Asn Uncertain significance Single submitter
- BAG4 p.Asp333Gly Uncertain significance Single submitter
- BAG4 p.Cys193Arg Uncertain significance Single submitter
- BAG4 p.Gln203Arg Uncertain significance Single submitter
- BAG4 p.Gln340Arg Uncertain significance Single submitter
- BAG4 p.Gln346His Uncertain significance Single submitter
- BAG4 p.Glu422Gln Uncertain significance Single submitter
- BAG4 p.Glu440Asp Uncertain significance Single submitter
- BAG4 p.Gly14Ser Uncertain significance Single submitter
- BAG4 p.Gly225Ser Uncertain significance Single submitter
- BAG4 p.Gly253Ser Uncertain significance Single submitter
- BAG4 p.Gly267Ser Uncertain significance Single submitter
- BAG4 p.Ile187Leu Uncertain significance Single submitter
- BAG4 p.Ile448Met Uncertain significance Single submitter
- BAG4 p.Leu123Ser Uncertain significance Single submitter
- BAG4 p.Leu63Gln Uncertain significance Single submitter
- BAG4 p.Lys403Glu Uncertain significance Single submitter
- BAG4 p.Pro142Arg Uncertain significance Single submitter
- BAG4 p.Pro182Ser Uncertain significance Single submitter
- BAG4 p.Pro284Arg Uncertain significance Single submitter
- BAG4 p.Pro288Ala Uncertain significance Single submitter
- BAG4 p.Ser100Tyr Uncertain significance Single submitter
- BAG4 p.Ser150Pro Uncertain significance Single submitter
- BAG4 p.Ser184Thr Uncertain significance Single submitter
- BAG4 p.Thr116Ala Uncertain significance Single submitter
- BAG4 p.Thr181Ile Uncertain significance Single submitter
- BAG4 p.Trp50Gly Uncertain significance Single submitter
- BAG4 p.Tyr156Asp Uncertain significance Single submitter
- BAG4 p.Tyr156His Uncertain significance Single submitter
- BAG4 p.Tyr173Ser Uncertain significance Single submitter
- BAG4 p.Val327Ala Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- BAG4 p.Arg311Trp Uncertain significance Single submitter
- BAG4 p.Glu65Lys Uncertain significance Single submitter
- BAG4 p.Gly25Asp Uncertain significance Single submitter
- BAG4 p.Gly267Asp Uncertain significance Single submitter
- BAG4 p.Gly429Arg Uncertain significance Single submitter
- BAG4 p.Gly429Glu Uncertain significance Single submitter
- BAG4 p.Pro199His Uncertain significance Single submitter
- BAG4 p.Pro33His Uncertain significance Single submitter
- BAG4 p.Pro57Leu Uncertain significance Single submitter
- BAG4 p.Ser152Ala Uncertain significance Single submitter
- BAG4 p.Ser164Asn Likely benign Single submitter
- BAG4 p.Ser166Phe Uncertain significance Single submitter
- BAG4 p.Ser303Asn Uncertain significance Single submitter
- BAG4 p.Ser308Cys Uncertain significance Single submitter
- BAG4 p.Ser332Leu Uncertain significance Single submitter
- BAG4 p.Ser363Ile Uncertain significance Single submitter
- BAG4 p.Ser433Phe Uncertain significance Single submitter
- BAG4 p.Thr132Lys Uncertain significance Single submitter
- BAG4 p.Thr405Ala Uncertain significance Single submitter
- BAG4 p.Trp186Cys Uncertain significance Single submitter
- BAG4 p.Tyr173His Uncertain significance Single submitter
- BAG4 p.Tyr17Phe Uncertain significance Single submitter
- BAG4 p.Tyr188Cys Uncertain significance Single submitter
- BAG4 p.Tyr73Cys Uncertain significance Single submitter
- BAG4 p.Tyr95His Uncertain significance Single submitter
All BAG4 variants
Likely benign 2
- p.Gly25Ser Single submitter
- p.Ser164Asn Single submitter ⚠
Uncertain significance 65
- p.Ala107Val Single submitter ⚠
- p.Ala157Val Single submitter ⚠
- p.Ala248Thr Single submitter ⚠
- p.Ala447Val Single submitter ⚠
- p.Arg185His Single submitter ⚠
- p.Arg311Trp Single submitter ⚠
- p.Arg40Leu Single submitter ⚠
- p.Arg51Gln Single submitter ⚠
- p.Arg84Gln Single submitter ⚠
- p.Asn350Ser Single submitter ⚠
- p.Asp297Glu Single submitter ⚠
- p.Asp330Asn Single submitter ⚠
- p.Asp333Gly Single submitter ⚠
- p.Cys193Arg Single submitter ⚠
- p.Gln203Arg Single submitter ⚠
- p.Gln340Arg Single submitter ⚠
- p.Gln346His Single submitter ⚠
- p.Glu422Gln Single submitter ⚠
- p.Glu440Asp Single submitter ⚠
- p.Glu65Lys Single submitter ⚠
- p.Gly14Ser Single submitter ⚠
- p.Gly225Ser Single submitter ⚠
- p.Gly253Ser Single submitter ⚠
- p.Gly25Asp Single submitter ⚠
- p.Gly267Asp Single submitter ⚠
- p.Gly267Ser Single submitter ⚠
- p.Gly429Arg Single submitter ⚠
- p.Gly429Glu Single submitter ⚠
- p.Ile187Leu Single submitter ⚠
- p.Ile448Met Single submitter ⚠
- p.Leu123Ser Single submitter ⚠
- p.Leu63Gln Single submitter ⚠
- p.Lys403Glu Single submitter ⚠
- p.Pro142Arg Single submitter ⚠
- p.Pro182Ser Single submitter ⚠
- p.Pro199His Single submitter ⚠
- p.Pro284Arg Single submitter ⚠
- p.Pro288Ala Single submitter ⚠
- p.Pro33His Single submitter ⚠
- p.Pro57Leu Single submitter ⚠
- p.Ser100Tyr Single submitter ⚠
- p.Ser150Pro Single submitter ⚠
- p.Ser152Ala Single submitter ⚠
- p.Ser166Phe Single submitter ⚠
- p.Ser184Thr Single submitter ⚠
- p.Ser303Asn Single submitter ⚠
- p.Ser308Cys Single submitter ⚠
- p.Ser332Leu Single submitter ⚠
- p.Ser363Ile Single submitter ⚠
- p.Ser433Phe Single submitter ⚠
- p.Thr116Ala Single submitter ⚠
- p.Thr132Lys Single submitter ⚠
- p.Thr181Ile Single submitter ⚠
- p.Thr405Ala Single submitter ⚠
- p.Trp186Cys Single submitter ⚠
- p.Trp50Gly Single submitter ⚠
- p.Tyr156Asp Single submitter ⚠
- p.Tyr156His Single submitter ⚠
- p.Tyr173His Single submitter ⚠
- p.Tyr173Ser Single submitter ⚠
- p.Tyr17Phe Single submitter ⚠
- p.Tyr188Cys Single submitter ⚠
- p.Tyr73Cys Single submitter ⚠
- p.Tyr95His Single submitter ⚠
- p.Val327Ala Single submitter ⚠