BARX1 — 35 ClinVar variants
All ClinVar germline BARX1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 30 flagged for review →
35 Uncertain significance
Full BARX1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 30
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BARX1 p.Ala103Gly Uncertain significance Single submitter
- BARX1 p.Ala112Thr Uncertain significance Single submitter
- BARX1 p.Ala129Glu Uncertain significance Single submitter
- BARX1 p.Ala19Pro Uncertain significance Single submitter
- BARX1 p.Ala45Glu Uncertain significance Single submitter
- BARX1 p.Ala45Thr Uncertain significance Single submitter
- BARX1 p.Arg11Pro Uncertain significance Single submitter
- BARX1 p.Arg22Trp Uncertain significance Single submitter
- BARX1 p.Gln164His Uncertain significance Single submitter
- BARX1 p.Gln62Arg Uncertain significance Single submitter
- BARX1 p.Glu162Ala Uncertain significance Single submitter
- BARX1 p.Glu226Asp Uncertain significance Single submitter
- BARX1 p.Glu238Lys Uncertain significance Single submitter
- BARX1 p.Glu242Val Uncertain significance Single submitter
- BARX1 p.Gly8Ala Uncertain significance Single submitter
- BARX1 p.Leu228Val Uncertain significance Single submitter
- BARX1 p.Lys58Arg Uncertain significance Single submitter
- BARX1 p.Pro14Thr Uncertain significance Single submitter
- BARX1 p.Pro4Ser Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- BARX1 p.Ala111Asp Uncertain significance Single submitter
- BARX1 p.Ala51Thr Uncertain significance Single submitter
- BARX1 p.Ala63Thr Uncertain significance Single submitter
- BARX1 p.Arg25Cys Uncertain significance Single submitter
- BARX1 p.Asp171Glu Uncertain significance Single submitter
- BARX1 p.Cys94Arg Uncertain significance Single submitter
- BARX1 p.Glu151Asp Uncertain significance Single submitter
- BARX1 p.Leu92Pro Uncertain significance Single submitter
- BARX1 p.Leu97Pro Uncertain significance Single submitter
- BARX1 p.Phe59Cys Uncertain significance Single submitter
- BARX1 p.Thr36Met Uncertain significance Single submitter
All BARX1 variants
Uncertain significance 35
- p.Ala103Gly Single submitter ⚠
- p.Ala111Asp Single submitter ⚠
- p.Ala112Thr Single submitter ⚠
- p.Ala129Glu Single submitter ⚠
- p.Ala19Pro Single submitter ⚠
- p.Ala45Glu Single submitter ⚠
- p.Ala45Thr Single submitter ⚠
- p.Ala51Thr Single submitter ⚠
- p.Ala63Thr Single submitter ⚠
- p.Arg11Pro Single submitter ⚠
- p.Arg22Gln Single submitter
- p.Arg22Trp Single submitter ⚠
- p.Arg25Cys Single submitter ⚠
- p.Asp171Glu Single submitter ⚠
- p.Cys94Arg Single submitter ⚠
- p.Gln164His Single submitter ⚠
- p.Gln62Arg Single submitter ⚠
- p.Glu151Asp Single submitter ⚠
- p.Glu162Ala Single submitter ⚠
- p.Glu226Asp Single submitter ⚠
- p.Glu238Lys Single submitter ⚠
- p.Glu242Val Single submitter ⚠
- p.Glu55Ala Single submitter
- p.Gly8Ala Single submitter ⚠
- p.Ile222Val Single submitter
- p.Leu123Phe Single submitter
- p.Leu228Val Single submitter ⚠
- p.Leu92Pro Single submitter ⚠
- p.Leu97Pro Single submitter ⚠
- p.Lys58Arg Single submitter ⚠
- p.Phe59Cys Single submitter ⚠
- p.Pro14Thr Single submitter ⚠
- p.Pro4Ser Single submitter ⚠
- p.Ser98Ile Single submitter
- p.Thr36Met Single submitter ⚠