BCL2 — 9 ClinVar variants
All ClinVar germline BCL2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 6 flagged for review →
2 Benign · 1 Likely benign · 6 Uncertain significance
Full BCL2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 6
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 2
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 4
The independent predictors disagree with each other — read with care.
All BCL2 variants
Benign 2
Likely benign 1
- p.Phe153= Single submitter
Uncertain significance 6
- p.Ala113Asp Single submitter ⚠
- p.Gly79Asp Single submitter ⚠
- p.Met166Leu Single submitter ⚠
- p.Phe150Leu Single submitter ⚠
- p.Phe153Tyr Single submitter ⚠
- p.Ser24Leu Single submitter ⚠