BCL2L13 — 84 ClinVar variants
All ClinVar germline BCL2L13 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 73 flagged for review →
2 Benign · 8 Likely benign · 74 Uncertain significance
Full BCL2L13 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 73
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 62
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BCL2L13 p.Ala325Pro Uncertain significance Single submitter
- BCL2L13 p.Ala341Asp Uncertain significance Single submitter
- BCL2L13 p.Ala416Pro Uncertain significance Single submitter
- BCL2L13 p.Ala467Thr Uncertain significance Single submitter
- BCL2L13 p.Arg137Gln Uncertain significance Single submitter
- BCL2L13 p.Arg137Gly Uncertain significance Single submitter
- BCL2L13 p.Arg169Thr Uncertain significance Single submitter
- BCL2L13 p.Arg170Cys Uncertain significance Single submitter
- BCL2L13 p.Arg332Trp Uncertain significance Single submitter
- BCL2L13 p.Asn415Ile Uncertain significance Single submitter
- BCL2L13 p.Asp52His Uncertain significance Single submitter
- BCL2L13 p.Gln278Glu Uncertain significance Single submitter
- BCL2L13 p.Gln34His Uncertain significance Single submitter
- BCL2L13 p.Glu166Gln Uncertain significance Single submitter
- BCL2L13 p.Glu265Gln Uncertain significance Single submitter
- BCL2L13 p.Glu317Lys Uncertain significance Single submitter
- BCL2L13 p.Glu321Gly Uncertain significance Single submitter
- BCL2L13 p.Glu333Asp Uncertain significance Single submitter
- BCL2L13 p.Glu430Lys Uncertain significance Single submitter
- BCL2L13 p.Glu448Lys Uncertain significance Single submitter
- BCL2L13 p.Glu66Asp Uncertain significance Single submitter
- BCL2L13 p.Gly457Asp Uncertain significance Single submitter
- BCL2L13 p.Gly477Arg Uncertain significance Single submitter
- BCL2L13 p.His106Tyr Uncertain significance Single submitter
- BCL2L13 p.His146Pro Uncertain significance Single submitter
- BCL2L13 p.His348Arg Uncertain significance Single submitter
- BCL2L13 p.His86Arg Uncertain significance Single submitter
- BCL2L13 p.Ile349Thr Uncertain significance Single submitter
- BCL2L13 p.Ile460Met Uncertain significance Single submitter
- BCL2L13 p.Ile55Met Uncertain significance Single submitter
- BCL2L13 p.Leu107Phe Uncertain significance Single submitter
- BCL2L13 p.Leu115Val Uncertain significance Single submitter
- BCL2L13 p.Leu380Phe Uncertain significance Single submitter
- BCL2L13 p.Leu380Pro Uncertain significance Single submitter
- BCL2L13 p.Leu409Pro Uncertain significance Single submitter
- BCL2L13 p.Lys369Arg Uncertain significance Single submitter
- BCL2L13 p.Lys431Glu Uncertain significance Single submitter
- BCL2L13 p.Met452Val Uncertain significance Single submitter
- BCL2L13 p.Pro130Ala Uncertain significance Single submitter
- BCL2L13 p.Pro228Ser Uncertain significance Single submitter
- BCL2L13 p.Pro228Thr Uncertain significance Single submitter
- BCL2L13 p.Pro253Ser Uncertain significance Single submitter
- BCL2L13 p.Pro339Ala Uncertain significance Single submitter
- BCL2L13 p.Pro347Leu Uncertain significance Single submitter
- BCL2L13 p.Pro400His Uncertain significance Single submitter
- BCL2L13 p.Pro436Gln Uncertain significance Single submitter
- BCL2L13 p.Pro445Arg Uncertain significance Single submitter
- BCL2L13 p.Pro451Ser Uncertain significance Single submitter
- BCL2L13 p.Pro453Leu Uncertain significance Single submitter
- BCL2L13 p.Pro96Ala Uncertain significance Single submitter
- BCL2L13 p.Ser257Leu Uncertain significance Single submitter
- BCL2L13 p.Ser410Asn Uncertain significance Single submitter
- BCL2L13 p.Ser426Pro Uncertain significance Single submitter
- BCL2L13 p.Ser98Gly Uncertain significance Single submitter
- BCL2L13 p.Thr374Ala Uncertain significance Single submitter
- BCL2L13 p.Thr393Ala Uncertain significance Single submitter
- BCL2L13 p.Thr79Ile Uncertain significance Single submitter
- BCL2L13 p.Tyr189Cys Uncertain significance Single submitter
- BCL2L13 p.Val398Met Uncertain significance Single submitter
- BCL2L13 p.Val434Met Uncertain significance Single submitter
- BCL2L13 p.Val469Phe Uncertain significance Single submitter
- BCL2L13 p.Val7Met Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- BCL2L13 p.Ala135Pro Uncertain significance Single submitter
- BCL2L13 p.Asp290Gly Uncertain significance Single submitter
- BCL2L13 p.Glu187Gly Uncertain significance Single submitter
- BCL2L13 p.Glu296Gly Uncertain significance Single submitter
- BCL2L13 p.Ile226Val Uncertain significance Single submitter
- BCL2L13 p.Leu107Arg Uncertain significance Single submitter
- BCL2L13 p.Leu154Ser Uncertain significance Single submitter
- BCL2L13 p.Lys484Asn Uncertain significance Single submitter
- BCL2L13 p.Thr15Ala Uncertain significance Single submitter
- BCL2L13 p.Tyr17His Uncertain significance Single submitter
- BCL2L13 p.Val183Met Uncertain significance Single submitter
All BCL2L13 variants
Benign 2
- p.Ile46Thr Multiple submitters
- p.Ala191Ser Single submitter
Likely benign 8
- p.Ala401Thr Single submitter
- p.Arg161Gln Single submitter
- p.Ile476Val Single submitter
- p.Lys412Glu Single submitter
- p.Pro435Leu Single submitter
- p.Pro436Leu Single submitter
- p.Ser429Gly Single submitter
- p.Thr407Met Single submitter
Uncertain significance 74
- p.Ala135Pro Single submitter ⚠
- p.Ala325Pro Single submitter ⚠
- p.Ala341Asp Single submitter ⚠
- p.Ala416Pro Single submitter ⚠
- p.Ala467Thr Single submitter ⚠
- p.Arg137Gln Single submitter ⚠
- p.Arg137Gly Single submitter ⚠
- p.Arg169Thr Single submitter ⚠
- p.Arg170Cys Single submitter ⚠
- p.Arg332Trp Single submitter ⚠
- p.Asn415Ile Single submitter ⚠
- p.Asp290Gly Single submitter ⚠
- p.Asp52His Single submitter ⚠
- p.Gln278Glu Single submitter ⚠
- p.Gln34His Single submitter ⚠
- p.Glu166Gln Single submitter ⚠
- p.Glu187Gly Single submitter ⚠
- p.Glu265Gln Single submitter ⚠
- p.Glu296Gly Single submitter ⚠
- p.Glu317Lys Single submitter ⚠
- p.Glu321Gly Single submitter ⚠
- p.Glu333Asp Single submitter ⚠
- p.Glu430Lys Single submitter ⚠
- p.Glu448Lys Single submitter ⚠
- p.Glu66Asp Single submitter ⚠
- p.Gly149Asp Single submitter
- p.Gly457Asp Single submitter ⚠
- p.Gly477Arg Single submitter ⚠
- p.His106Tyr Single submitter ⚠
- p.His146Pro Single submitter ⚠
- p.His348Arg Single submitter ⚠
- p.His86Arg Single submitter ⚠
- p.Ile226Val Single submitter ⚠
- p.Ile349Thr Single submitter ⚠
- p.Ile460Met Single submitter ⚠
- p.Ile55Met Single submitter ⚠
- p.Leu107Arg Single submitter ⚠
- p.Leu107Phe Single submitter ⚠
- p.Leu115Val Single submitter ⚠
- p.Leu154Ser Single submitter ⚠
- p.Leu380Phe Single submitter ⚠
- p.Leu380Pro Single submitter ⚠
- p.Leu409Pro Single submitter ⚠
- p.Lys369Arg Single submitter ⚠
- p.Lys431Glu Single submitter ⚠
- p.Lys484Asn Single submitter ⚠
- p.Met452Val Single submitter ⚠
- p.Pro130Ala Single submitter ⚠
- p.Pro228Ser Single submitter ⚠
- p.Pro228Thr Single submitter ⚠
- p.Pro253Ser Single submitter ⚠
- p.Pro339Ala Single submitter ⚠
- p.Pro347Leu Single submitter ⚠
- p.Pro400His Single submitter ⚠
- p.Pro436Gln Single submitter ⚠
- p.Pro445Arg Single submitter ⚠
- p.Pro451Ser Single submitter ⚠
- p.Pro453Leu Single submitter ⚠
- p.Pro96Ala Single submitter ⚠
- p.Ser257Leu Single submitter ⚠
- p.Ser410Asn Single submitter ⚠
- p.Ser426Pro Single submitter ⚠
- p.Ser98Gly Single submitter ⚠
- p.Thr15Ala Single submitter ⚠
- p.Thr374Ala Single submitter ⚠
- p.Thr393Ala Single submitter ⚠
- p.Thr79Ile Single submitter ⚠
- p.Tyr17His Single submitter ⚠
- p.Tyr189Cys Single submitter ⚠
- p.Val183Met Single submitter ⚠
- p.Val398Met Single submitter ⚠
- p.Val434Met Single submitter ⚠
- p.Val469Phe Single submitter ⚠
- p.Val7Met Single submitter ⚠