BCL2L14 — 46 ClinVar variants
All ClinVar germline BCL2L14 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
1 Benign · 1 Likely benign · 44 Uncertain significance
Full BCL2L14 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 38
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BCL2L14 p.Ala280Thr Uncertain significance Single submitter
- BCL2L14 p.Ala284Ser Uncertain significance Single submitter
- BCL2L14 p.Ala28Thr Uncertain significance Single submitter
- BCL2L14 p.Arg132Gly Uncertain significance Single submitter
- BCL2L14 p.Arg132Ser Uncertain significance Single submitter
- BCL2L14 p.Arg156Gly Uncertain significance Single submitter
- BCL2L14 p.Arg51Ile Uncertain significance Single submitter
- BCL2L14 p.Asp15Gly Uncertain significance Single submitter
- BCL2L14 p.Asp16His Uncertain significance Single submitter
- BCL2L14 p.Asp327Asn Uncertain significance Single submitter
- BCL2L14 p.Asp327His Uncertain significance Single submitter
- BCL2L14 p.Cys133Tyr Uncertain significance Single submitter
- BCL2L14 p.Gln168Pro Uncertain significance Single submitter
- BCL2L14 p.Gln171His Uncertain significance Single submitter
- BCL2L14 p.Glu142Gly Uncertain significance Single submitter
- BCL2L14 p.Glu205Lys Uncertain significance Single submitter
- BCL2L14 p.Glu65Gln Uncertain significance Single submitter
- BCL2L14 p.His143Asn Uncertain significance Single submitter
- BCL2L14 p.His323Arg Uncertain significance Single submitter
- BCL2L14 p.His34Tyr Uncertain significance Single submitter
- BCL2L14 p.Ile249Met Uncertain significance Single submitter
- BCL2L14 p.Ile285Thr Uncertain significance Single submitter
- BCL2L14 p.Leu190Phe Uncertain significance Single submitter
- BCL2L14 p.Leu319Pro Uncertain significance Single submitter
- BCL2L14 p.Leu42Ile Uncertain significance Single submitter
- BCL2L14 p.Lys111Arg Uncertain significance Single submitter
- BCL2L14 p.Pro166Ser Uncertain significance Single submitter
- BCL2L14 p.Ser44Leu Uncertain significance Single submitter
- BCL2L14 p.Thr108Met Uncertain significance Single submitter
- BCL2L14 p.Trp72Arg Uncertain significance Single submitter
- BCL2L14 p.Val112Leu Uncertain significance Single submitter
- BCL2L14 p.Val137Met Uncertain significance Single submitter
- BCL2L14 p.Val194Ala Uncertain significance Single submitter
- BCL2L14 p.Val196Glu Uncertain significance Single submitter
- BCL2L14 p.Val213Ala Uncertain significance Single submitter
- BCL2L14 p.Val253Ile Uncertain significance Single submitter
- BCL2L14 p.Val326Ala Uncertain significance Single submitter
- BCL2L14 p.Val326Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- BCL2L14 p.Arg292Ser Uncertain significance Single submitter
- BCL2L14 p.Asn291Lys Uncertain significance Single submitter
- BCL2L14 p.Asp277Glu Uncertain significance Single submitter
- BCL2L14 p.Lys281Asn Uncertain significance Single submitter
- BCL2L14 p.Lys89Ile Uncertain significance Single submitter
- BCL2L14 p.Lys90Asn Uncertain significance Single submitter
All BCL2L14 variants
Benign 1
- p.Glu69= Multiple submitters
Likely benign 1
- p.Arg56Lys Single submitter
Uncertain significance 44
- p.Ala280Thr Single submitter ⚠
- p.Ala284Ser Single submitter ⚠
- p.Ala28Thr Single submitter ⚠
- p.Arg132Gly Single submitter ⚠
- p.Arg132Ser Single submitter ⚠
- p.Arg156Gly Single submitter ⚠
- p.Arg292Ser Single submitter ⚠
- p.Arg51Ile Single submitter ⚠
- p.Asn291Lys Single submitter ⚠
- p.Asp15Gly Single submitter ⚠
- p.Asp16His Single submitter ⚠
- p.Asp277Glu Single submitter ⚠
- p.Asp327Asn Single submitter ⚠
- p.Asp327His Single submitter ⚠
- p.Cys133Tyr Single submitter ⚠
- p.Gln168Pro Single submitter ⚠
- p.Gln171His Single submitter ⚠
- p.Glu142Gly Single submitter ⚠
- p.Glu205Lys Single submitter ⚠
- p.Glu65Gln Single submitter ⚠
- p.His143Asn Single submitter ⚠
- p.His323Arg Single submitter ⚠
- p.His34Tyr Single submitter ⚠
- p.Ile249Met Single submitter ⚠
- p.Ile285Thr Single submitter ⚠
- p.Leu190Phe Single submitter ⚠
- p.Leu319Pro Single submitter ⚠
- p.Leu42Ile Single submitter ⚠
- p.Lys111Arg Single submitter ⚠
- p.Lys281Asn Single submitter ⚠
- p.Lys89Ile Single submitter ⚠
- p.Lys90Asn Single submitter ⚠
- p.Pro166Ser Single submitter ⚠
- p.Ser44Leu Single submitter ⚠
- p.Thr108Met Single submitter ⚠
- p.Trp72Arg Single submitter ⚠
- p.Val112Leu Single submitter ⚠
- p.Val137Met Single submitter ⚠
- p.Val194Ala Single submitter ⚠
- p.Val196Glu Single submitter ⚠
- p.Val213Ala Single submitter ⚠
- p.Val253Ile Single submitter ⚠
- p.Val326Ala Single submitter ⚠
- p.Val326Ile Single submitter ⚠