Sugi Variant

Sugi Variant/BDNF

BDNF — 140 ClinVar variants

All ClinVar germline BDNF variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 48 flagged for review →

2 Likely pathogenic · 1 Conflicting · 16 Benign · 47 Likely benign · 74 Uncertain significance

Full BDNF gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 48

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 40

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 8

The independent predictors disagree with each other — read with care.

All BDNF variants

Likely pathogenic 2

Conflicting classifications of pathogenicity 1

Benign 16

Likely benign 47

Uncertain significance 74